Occupational Health And Safety In The Care And Use Of Research Animals

Author by : National Research Council
Languange : en
Publisher by : National Academies Press
Format Available : PDF, ePub, Mobi
Total Read : 88
Total Download : 970
File Size : 53,8 Mb
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Description : Much has been written about the care of research animals. Yet little guidance has appeared on protecting the health and safety of the people who care for or use these animals. This book, an implementation handbook and companion to Guide For the Care and Use of Laboratory Animals, identifies principles for building a program and discusses the accountability of institutional leaders, managers, and employees for a program's success. It provides a detailed description of risks-- physical and chemical hazards, allergens and zoonoses, and hazards from experiments--which will serve as a continuing reference for the laboratory. The book offers specific recommendations for controlling risk through administrative procedures, facility design, engineering controls, and periodic evaluations. The volume focuses on the worker, with detailed discussions of work practices, the use of personal protective gear, and the development of an emergency response plan. This handbook will be invaluable to administrators, researchers, and employees in any animal research facility. It will also be of interest to personnel in zoos, animal shelters, and veterinary facilities.


Occupational Health And Safety In The Care And Use Of Research Animals

Author by : National Research Council
Languange : en
Publisher by : National Academies Press
Format Available : PDF, ePub, Mobi
Total Read : 97
Total Download : 658
File Size : 52,9 Mb
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Description : Much has been written about the care of research animals. Yet little guidance has appeared on protecting the health and safety of the people who care for or use these animals. This book, an implementation handbook and companion to Guide For the Care and Use of Laboratory Animals, identifies principles for building a program and discusses the accountability of institutional leaders, managers, and employees for a program's success. It provides a detailed description of risks-- physical and chemical hazards, allergens and zoonoses, and hazards from experiments--which will serve as a continuing reference for the laboratory. The book offers specific recommendations for controlling risk through administrative procedures, facility design, engineering controls, and periodic evaluations. The volume focuses on the worker, with detailed discussions of work practices, the use of personal protective gear, and the development of an emergency response plan. This handbook will be invaluable to administrators, researchers, and employees in any animal research facility. It will also be of interest to personnel in zoos, animal shelters, and veterinary facilities.


Occupational Health And Safety In The Care And Use Of Nonhuman Primates

Author by : National Research Council
Languange : en
Publisher by : National Academies Press
Format Available : PDF, ePub, Mobi
Total Read : 80
Total Download : 754
File Size : 46,8 Mb
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Description : The field of occupational health and safety constantly changes, especially as it pertains to biomedical research. New infectious hazards are of particular importance at nonhuman-primate facilities. For example, the discovery that B virus can be transmitted via a splash on a mucous membrane raises new concerns that must be addressed, as does the discovery of the Reston strain of Ebola virus in import quarantine facilities in the U.S. The risk of such infectious hazards is best managed through a flexible and comprehensive Occupational Health and Safety Program (OHSP) that can identify and mitigate potential hazards. Occupational Health and Safety in the Care and Use of Nonhuman Primates is intended as a reference for vivarium managers, veterinarians, researchers, safety professionals, and others who are involved in developing or implementing an OHSP that deals with nonhuman primates. The book lists the important features of an OHSP and provides the tools necessary for informed decision-making in developing an optimal program that meets all particular institutional needs.


Management Of Animal Care And Use Programs In Research Education And Testing

Author by : Robert H. Weichbrod
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 92
Total Download : 792
File Size : 54,7 Mb
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Description : AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).


Guide For The Care And Use Of Laboratory Animals

Author by : National Research Council
Languange : en
Publisher by : National Academies Press
Format Available : PDF, ePub, Mobi
Total Read : 61
Total Download : 264
File Size : 45,9 Mb
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Description : A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.


Management Of Laboratory Animal Care And Use Programs

Author by : Mark A. Suckow
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 40
Total Download : 923
File Size : 52,7 Mb
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Description : The management of biomedical research using animals has become increasingly complex due to new technology, increased regulatory oversight, and recognition of the need for animals free of disease and distress. Within this changing environment, individuals charged with the management of laboratory animal facilities have a substantial responsibility to the institution, the public, and the animals. Management of Laboratory Animals Care and Use Programs provides both factual and theoretical information drawn from the substantial experience of authors who are noted experts in the field. This book will provide individuals with the basic knowledge and information necessary to meet typical professional challenges. A co-publication with the American Association for Laboratory Animal Science, this valuable book serves as the text for the Certified Manager Animal Resources (CMAR) exam.


Laboratory Animals

Author by : Javier Guillen
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 74
Total Download : 323
File Size : 41,7 Mb
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Description : Laboratory Animals: Regulations and Recommendations for Global Collaborative Research is the only publication to offer a compilation of standards across the world in the care, welfare and use of animals in research. Timely in the new legislation in numerous regions of the world, this book provides the information in easily accessible, readable language. For professionals across laboratory animal science and biomedical research, Laboratory Animals: Regulations and Recommendations for Global Collaborative Research provides a broad picture of the regulations required in other areas of the world and is essential to appropriately manage animal care and use programs. Offers a worldwide view and global compilation of regulations, guidelines and recommendations for laboratory animal research Saves valuable time researching different regional legislation and regulations Provides insight into factors that play roles in the regulatory framework for countries and geographic regions Written in "layman’s" terms to easily understand legislation and regulations


Clinical Laboratory Animal Medicine

Author by : Lesley A. Colby
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 19
Total Download : 796
File Size : 54,5 Mb
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Description : The revised fifth edition of Clinical Laboratory Animal Medicine: An Introduction is an accessible guide to basic information for conducting animal research safely and responsibly. It includes a review of the unique anatomic and physiologic characteristics of laboratory animals, husbandry practices, and veterinary care of many animals frequently used in research, including rodents, rabbits, ferrets, zebrafish, nonhuman primates, and agricultural animals. The updated fifth edition adds two new chapters on zebrafish and large animals, new information on transgenic models and genetic editing, and expanded coverage of environmental enrichment and pain management. The book presents helpful tip boxes, images, and review questions to aid in comprehension and learning, and a companion website provides editable review questions and answers, instructional PowerPoints, and additional images not found in the book. This important text: • Provides a complete introduction to laboratory animal husbandry, diseases, and treatments • Offers a user-friendly format with helpful content that highlights important concepts • Contains new knowledge relating to technical methodologies, diseases, drug dosages, laws and regulations, and organizations • Covers information on regulations, facilities, equipment, housing, and research variables as well as veterinary care • Includes new chapters on zebrafish and cattle, sheep, goats, and pigs Written for veterinary technicians, veterinary students, practicing veterinarians, and research scientists, the fifth edition of Clinical Laboratory Animal Medicine continues to offer an essential guide to the ethical treatment and anatomic and physiological characteristics of research animals.


Principles Of Animal Research For Graduate And Undergraduate Students

Author by : Mark A. Suckow
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 62
Total Download : 728
File Size : 47,5 Mb
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Description : Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all aspects of the research experience, including the research and development of a thesis, model selection, experimental design, IACUC protocol preparation, and animal husbandry and technical procedural needs, the book is a necessary addition to every student, technician, and researcher’s education. Provides background material for students to understand the broader backdrop against which animal research is undertaken Includes ethical and regulatory information Covers commonly used animal models and the process to choose a model for biomedical research


Guide For The Care And Use Of Laboratory Animals

Author by : Anonim
Languange : en
Publisher by : National Academies Press
Format Available : PDF, ePub, Mobi
Total Read : 25
Total Download : 300
File Size : 40,6 Mb
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Description : Demonstrates how computers, logic controllers (PLCs) and programmable logic devices (PLDs) have in common the characteristics of being synchronous sequential systems, and differ with regard to modularity, design confidentiality and speed. The first section introduces logic controllers and makes the connection between digital electronics and PLCs. The second section is dedicated to PLDs and their use in designing PLCs. The final section considers PLCs and their applications, and PLC programming languages. Annotation copyrighted by Book News, Inc., Portland, OR


Using Animal Models In Biomedical Research

Author by : Pierce K. H. Chow
Languange : en
Publisher by : World Scientific
Format Available : PDF, ePub, Mobi
Total Read : 80
Total Download : 851
File Size : 42,5 Mb
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Description : Ch. 1. Scientific considerations and choice of species. ch. 1.1. The rationale for the use of animal models in biomedical research / Pierce Chow. ch. 1.2. Experimental animal models in biomedical resarch / Robert Ng. ch. 1.3. Nonhuman primates as models in biomedical research / Jason Vilano and Bryan Ogden -- ch. 2. Regulatory considerations in the use of animal models. ch. 2.1. Laws, regulations and guidelines for biomedical research in Singapore / Boon Theng Kuah. ch. 2.2. The functions of the institutional animal care and use committee / Pierce Chow. ch. 2.3. Responsibilities of principal investigators and research protocol evaluation / Hock Soo Ong. ch. 2.4. The 3R's, research variables and the use of alternatives / Hock Soo Ong. ch. 2.5. Use of statistics as determinant for number of animals used / Huihua Li. ch. 2.6. The advantages of accreditation with AAALAC / Bryan Ogden -- ch. 3. Animal handling and surgical procedures. ch. 3.1. General handling, restraint, oral dosing/gavage and injections in laboratory animals / Bryan Ogden. ch. 3.2. Blood collection from laboratory animals / Jason Villano. ch. 3.3. Antibiotic coverage and therapy / Darvi Sergio. ch. 3.4. Animal preparation and transport / Robert Ng. ch. 3.5. Preparation and implementation of animal surgery / Robert Ng. ch. 3.6. Animal intubation / Robert Ng. ch. 3.7. Anaesthesia and maintenance of homeostasis / Robert Ng. ch. 3.8. Animal euthanasia / Darvi Sergio. ch. 3.9. Rodent sentinel programme / Peik Khin Tan -- ch. 4. Basic animal investigative methods. ch. 4.1. Bioimaging in animals / David Ng ... [et al.]. ch. 4.2. Histology sampling and techniques / In Chin Song. ch. 4.3. Animal tissue perfusion and preservation / Robert Ng. ch. 4.4. Animal cell culture / Kai Zhang and Peggy Yong. ch. 4.5. Application of microsurgical techniques in animal research / Bien Keem Tan ... [et al.] -- ch. 5. Animal welfare considerations. ch. 5.1. Species specific caging configuration and design / Cindy Phua. ch. 5.2. Postoperative care and pain management / Jason Villano. ch. 5.3. Animal feeds and nutritional requirements / Peik Khin Tan -- ch. 6. Safety management of an animal facility. ch. 6.1. Occupational health and safety programme / Angela Goh. ch. 6.2. New employee and external users orientation / Inria Kurniawan Then. ch. 6.3. Radiation safety awareness in animal research / S. Somanesan. ch. 6.4. Emergency crisis management / Irene Kee. ch. 6.5. Zoonoses and laboratory animal allergies / Jason Villano -- ch. 7. Supporting facilities design. ch. 7.1. Clinical skills laboratory / Robert Ng. ch. 7.2. Animal research supporting laboratories / Robert Ng. ch. 7.3. Animal research and housing facilities / Robert Ng -- ch. 8. The development of comprehensive animal facilities in Singapore. ch. 8.1. History of the Department of Experimental Surgery as a reflection of translational research development in Singapore / Robert Ng


The Laboratory Canine

Author by : Garrett Field
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 93
Total Download : 388
File Size : 55,8 Mb
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Description : Laboratory animals, including dogs, play an important role in biomedical research and medical advances. Dogs have a long history of use in research and have contributed enormously to the health and welfare of both humans and animals. The humane care and management of these animals is a fundamental component of their use in medical research. The Laboratory Canine clearly presents basic background information covering subjects that apply specifically to dogs used in research settings, such as basic biological features, husbandry, management, veterinary care, experimental methodology, and resources. The book offers guidance on performing a detailed physical examination, including necessary veterinary supplies, clinical signs of illness, clinical conditions, and reference tables of widely used veterinary drugs. It discusses the human-animal bond or the relationship between people and animals and its significance and importance to the quality of research, the health of the animals, and the emotional health of staff caring for or working with animals. It also examines anesthetic and surgical procedures that include pre-, intra-, and post-anesthesia/operative monitoring. The Laboratory Canine contains reference charts for monitoring patients through post-operative recovery and reference tables for anesthetics and analgesics. Because dogs are a highly visible species in the eyes of the public and regulators, it is important that individuals working with laboratory canines have the proper training and experience. This valuable resource is ideal for those charged with the care and use of canines in a research setting.


The Iacuc Handbook Second Edition

Author by : Jerald Silverman
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 16
Total Download : 957
File Size : 45,5 Mb
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Description : Since its establishment by USDA regulation in the mid-1980s, the Institutional Animal Care and Use Committee (IACUC) has evolved as the premier instrument of animal welfare oversight within research institutions in the United States. By addressing questions and problems that often confront institutions, The IACUC Handbook, Second Edition provides accurate, succinct answers. It features comprehensive updates for all pertinent federal laws, regulations, and policies. It also contains an expanded survey of IACUC practices from institutions around the nation. With accessible information, this new editionprovides a foundation for those attempting to understand and implement the many and varied responsibilities of these committees.


Clinical Laboratory Animal Medicine

Author by : Karen Hrapkiewicz
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 49
Total Download : 478
File Size : 53,5 Mb
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Description : Now in its third edition, Clinical Laboratory Animal Medicine serves as an introductory resource for veterinarians, veterinary technicians, veterinary students, and laboratory staff on treatment and management of laboratory animals, including mice, rats, gerbils, hamsters, guinea pigs, chinchillas, rabbits, ferrets, and non-human primates. Each species chapter follows a simple and easy-to-use format, covering behavior, anatomic and physiological features, breeding and reproduction, husbandry, handling and restraint, blood collection, urine collection, drug administration, anesthesia, surgery, postoperative care, therapeutic agents, and diseases. Convenient tables supply essential biological and physiological data, blood values, and information on drug dosaging. Appendices include normal values or hematological data and serum biochemical data, as well as a listing of organizations in laboratory animal medicine. Clinical Laboratory Animal Medicine not only facilitates safe and humane treatment of animals in laboratory settings but also can serve as a practical guide for veterinary practitioners and technicians who are faced with many of these same species in daily practice.


Essentials Of Laboratory Animal Science Principles And Practices

Author by : P. Nagarajan
Languange : en
Publisher by : Springer Nature
Format Available : PDF, ePub, Mobi
Total Read : 41
Total Download : 204
File Size : 55,9 Mb
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Description : This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.


The Laboratory Nonhuman Primate

Author by : Jeffrey D. Fortman
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 49
Total Download : 624
File Size : 43,9 Mb
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Description : Extensively updated to include current literature, The Laboratory Nonhuman Primate, Second Edition, continues to serve as a quick reference source for technicians, caretakers, veterinarians, researchers, and students working with primates in biomedical research. It provides details on basic husbandry and covers biologic characteristics, regulatory compliance, common diseases, and anesthetic management. The text gives easy-to-follow descriptions of basic technical procedures including restraint, intubation, tuberculin skin testing, and collection of blood and urine samples. It also reviews advanced sampling procedures including collection of bone marrow, cerebrospinal fluid, bronchoalveolar lavage fluid, and rectal mucosal biopsy. The Laboratory Nonhuman Primate presents information in a clear, concise format to allow readers to incorporate concepts and techniques into the standard operating procedures of a facility.


Handbook Of Laboratory Animal Anesthesia And Pain Management

Author by : Cholawat Pacharinsak
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 94
Total Download : 361
File Size : 44,7 Mb
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Description : Key features: Presents practical information in easily accessible ‘bullet point’ format Covers anesthetic machine and related equipment, anesthetic management and monitoring, anesthesia and analgesia pharmacology, euthanasia, and record keeping Written by well-recognized experts in the laboratory animal community Provides extensive references to direct the reader to sources for further study of alternative techniques and their procedures Concludes with a thorough chapter on Regulatory Management of Rodent Anesthesia which has global application Rodents are the most commonly used species in biomedical research. Individuals conducting rodent research are often responsible to ensure that all areas of anesthesia and analgesia are performed humanely. Anesthetic agent selection, anesthetic monitoring, and postoperative pain assessment and management are essential to the institutional animal care and use program and contribute significantly to the 3Rs by reducing pain and/or distress and refining various procedures. The Handbook of Laboratory Animal Anesthesia and Pain Management: Rodents is the first book to capture multiple advances in this important area that greatly impacts various experimental methodologies. Richly illustrated in full color, the book serves as a quick reference source for investigators, veterinarians, technicians, and other animal caretakers charged with the care and use of rodents in a research setting. The unique format of this book also makes it extremely valuable to IACUC members, institutional officials, and occupational health and safety professionals.


Animal Models For Assessing Countermeasures To Bioterrorism Agents

Author by : National Research Council
Languange : en
Publisher by : National Academies Press
Format Available : PDF, ePub, Mobi
Total Read : 56
Total Download : 641
File Size : 46,5 Mb
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Description : The Transformational Medical Technologies (TMT) has been a unique component of the U.S. Department of Defense (DoD) medical biodefense efforts since 2006. Its mission is to advance countermeasure research and development in support of the broader goal of the DoD to protect warfighters from emerging infectious diseases and future genetically engineered biological weapons. The TMT, using advanced science and technology approaches, focused on the development of roadspectrum countermeasures that target common host and pathogen pathways or enhance the host's immune response. Many of these pathogens are lethal or cause such debilitating diseases in humans that it is ethically inappropriate to test the efficacy of these countermeasures in human volunteers. In lieu of human participants, these products may be tested in animals and approved for human use under the provisions of the Food and Drug Administration (FDA)'s 2002 Animal Rule. The reliance on animal models for the development and licensure of medical countermeasures against biothreats is challenging for a number of reasons. The ad hoc Committee on Animal Models for Assessing Countermeasures to Bioterrorism Agents prepared a consensus report that would address the challenges stemming from developing and testing medical countermeasures against biothreat agents in animal models. Animal Models for Assessing Countermeasures to Bioterrorism Agents evaluates how well the existing TMT-employed or candidate animal models reflect the pathophysiology, clinical picture, and treatment of human disease as related to the agents of interest. The report addresses the process and/or feasibility of developing new animal models for critical biodefense research, placing emphasis on the need for a robust and expeditious validation process in terms of the FDA's Animal Rule. The report also evaluates alternatives to the use of animal models based on the premise of the Three Rs.


Recognition And Alleviation Of Distress In Laboratory Animals

Author by : National Research Council
Languange : en
Publisher by : National Academies Press
Format Available : PDF, ePub, Mobi
Total Read : 33
Total Download : 901
File Size : 50,9 Mb
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Description : Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. This new book from the Institute for Laboratory Animal Research (ILAR) at the National Research Council, Recognition and Alleviation of Distress in Laboratory Animals, focuses on the stress and distress which is experienced by animals when used in laboratory research. This book aims to educate laboratory animal veterinarians; students, researchers, and investigators; animal care staff, as well as animal welfare officers on the current scientific and ethical issues associated with stress and distress in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines. Recognition and Alleviation of Distress in Laboratory Animals focuses specifically on the scientific understanding of the causes and the functions of stress and distress, the transformation of stress to distress, and the identification of principles for the recognition and alleviation of distress. This book discusses the role of humane endpoints in situations of distress and principles for the minimization of distress in laboratory animals. It also identifies areas in which further scientific investigation is needed to improve laboratory animal welfare in order to adhere to scientific and ethical principles that promote humane care and practice.


Scientific And Humane Issues In The Use Of Random Source Dogs And Cats In Research

Author by : National Research Council
Languange : en
Publisher by : National Academies Press
Format Available : PDF, ePub, Mobi
Total Read : 33
Total Download : 719
File Size : 47,5 Mb
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Description : Scientific and Humane Issues in the Use of Random-Source Dogs and Cats in Research examines the value of random-source animals in biomedical research and the role of Class B dealers who acquire and resell live dogs and cats to research institutions. Findings include that, while some random-source dogs and cats may be necessary and desirable for National Institutes of Health (NIH)-funded research, there is no clear need to obtain those animals from Class B dealers. Several options for random-source animal acquisition already exist and additional options are recommended, which would further ensure the welfare of these animals and foster a positive public image for NIH. While the scientific community has recognized and responded to concerns for humane treatment of animals in research, government oversight has thus far been unable to fully enforce the Animal Welfare Act in regard to Class B dealers of live animals. Although the animals acquired by Class B dealers are destined for research--and NIH research in particular--the standard of care while in the possession of some Class B dealers requires an inordinate amount of government enforcement and is not commensurate with the policies of most NIH-funded research laboratories. This dichotomy of standards reflects poorly on public perceptions of NIH and jeopardizes animal welfare. This book will be crucial for NIH and other groups using random-source animals in research, including veterinary schools and research facilities. Animal welfare advocates, policy makers, and concerned pet owners will also find this a vital and informative work for reconciling the needs of research with the welfare of animals.


Laboratory Animal And Exotic Pet Medicine E Book

Author by : Margi Sirois
Languange : en
Publisher by : Elsevier Health Sciences
Format Available : PDF, ePub, Mobi
Total Read : 75
Total Download : 662
File Size : 41,8 Mb
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Description : Learn how to properly handle and care for lab animals and exotic species with Laboratory Animal and Exotic Pet Medicine, Principles and Procedures, 2nd Edition. This comprehensive resource provides the latest anatomy, physiology, and taxonomy information on a wide variety of species — including birds, reptiles and amphibians, rats and mice, guinea pigs, hamsters, rabbits, gerbils, ferrets, wildlife, woodchucks, armadillos, frogs, and fish. Coverage also includes a number of commonly performed procedures (such as blood collection, medicine administration, and animal husbandry) and in-depth information on housing, restraint, nutrition, common diseases, diagnostics, and therapeutics. Research-related information, including legal and ethical issues surrounding exotic animals being kept as pets, as well as the humane use of animals in research, make this text a must-have resource for any aspiring vet tech or professional who must work with lab animals. Comprehensive coverage addresses a wide variety of species (rats, mice, guinea pigs, hamsters, gerbils, ferrets, rabbits, nonhuman primates, swine, chinchillas, armadillos, amphibians, reptiles, birds, fish, farm animals, and cats and dogs) and covers a wide variety of topics (such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations) to fully prepare students for work with all types of animals. Consistent organization of each species chapter makes it easy for students to quickly identify similarities and differences among various laboratory animals. The latest information on laws and ethics related to lab animal medicine cover the areas of pain management, use, care, and more. Review questions at the end of each chapter allow students to assess their knowledge of the material. Discussion of specific uses for each species in biomedical research gives students a perspective on animal use that allows them to explain the benefits of animal use as required by veterinary technology program accreditation procedure. Boxes and tables list anatomic and physiologic data for each species. NEW! Updated design features more high-quality, full-color illustrations and a revised reader-friendly layout with learning objectives and key points to make content easier to follow.


Contract Research And Development Organizations Their History Selection And Utilization

Author by : Shayne C. Gad
Languange : en
Publisher by : Springer Nature
Format Available : PDF, ePub, Mobi
Total Read : 83
Total Download : 499
File Size : 49,6 Mb
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Description : This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: · The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. · Study directors and principal investigators. · The nuts and bolts of study performance. · Electronic reporting requirements – SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). · Consultants and their roles. · An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs – where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities – and for auditing studies and projects at such facilities – are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.


Recognition And Alleviation Of Pain In Laboratory Animals

Author by : National Research Council
Languange : en
Publisher by : National Academies Press
Format Available : PDF, ePub, Mobi
Total Read : 76
Total Download : 737
File Size : 43,7 Mb
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Description : The use of animals in research adheres to scientific and ethical principles that promote humane care and practice. Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. Recognition and Alleviation of Pain in Laboratory Animals, the second of two reports revising the 1992 publication Recognition and Alleviation of Pain and Distress in Laboratory Animals from the Institute for Laboratory Animal Research (ILAR), focuses on pain experienced by animals used in research. This book aims to educate laboratory animal veterinarians; students, researchers and investigators; Institutional Animal Care and Use Committee members; and animal care staff and animal welfare officers on the current scientific and ethical issues associated with pain in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines for recognizing and alleviating pain in laboratory animals, focusing specifically on the following areas: physiology of pain in commonly used laboratory species; pharmacologic and non-pharmacologic principles to control pain; identification of humane endpoints; and principles for minimizing pain associated with experimental procedures. Finally, the report identifies areas in which further scientific investigation is needed to improve laboratory animal welfare.


The Care And Feeding Of An Iacuc

Author by : Whitney Kayla Petrie
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 78
Total Download : 316
File Size : 41,7 Mb
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Description : Maintaining its user-friendly approach, The Care and Feeding of an IACUC: The Organization and Management of an Institutional Animal Care and Use Committee, Second Edition is a handy guide for members of the laboratory animal community looking for a concise, descriptive introduction to what an IACUC is all about and how it operates. The book covers


Biological Safety

Author by : Dawn P. Wooley
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 97
Total Download : 205
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Description : Biological safety and biosecurity protocols are essential to the reputation and responsibility of every scientific institution, whether research, academic, or production. Every risk—no matter how small—must be considered, assessed, and properly mitigated. If the science isn't safe, it isn't good. Now in its fifth edition, Biological safety: Principles and Practices remains the most comprehensive biosafety reference. Led by editors Karen Byers and Dawn Wooley, a team of expert contributors have outlined the technical nuts and bolts of biosafety and biosecurity within these pages. This book presents the guiding principles of laboratory safety, including: the identification, assessment, and control of the broad variety of risks encountered in the lab; the production facility; and, the classroom. Specifically, Biological Safety covers protection and control elements—from biosafety level cabinets and personal protection systems to strategies and decontamination methods administrative concerns in biorisk management, including regulations, guidelines, and compliance various aspects of risk assessment covering bacterial pathogens, viral agents, mycotic agents, protozoa and helminths, gene transfer vectors, zooonotic agents, allergens, toxins, and molecular agents as well as decontamination, aerobiology, occupational medicine, and training A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological safety is also a critical reference for laboratory managers, and those responsible for managing biohazards in a range of settings, including basic and agricultural research, clinical laboratories, the vivarium, field study, insectories, and greenhouses.