Oxidative Stress and Age Related Neurodegeneration

Oxidative Stress and Age Related Neurodegeneration
Author: Yuan Luo
Publsiher: CRC Press
Total Pages: 528
Release: 2005-11-21
ISBN: 9780849337253
Category: Science
Language: EN, FR, DE, ES & NL

Oxidative Stress and Age Related Neurodegeneration Book Excerpt:

Despite the progress being made by researchers, Alzheimer’s disease, along with other age-related neurodegenerative disorders, continues to exact a tremendous toll on our society. However, we are beginning to see a relationship that ties degenerative disorders to oxidative stress and lifestyle, suggesting the possibility for prevention and intervention through changes of individual habits, especially with regard to diet. Oxidative Stress and Age-Related Neurodegeneration brings together expert researchers involved with recent developments across a variety of fields. In looking at causation, prevention, and therapy, they offer contributions addressing these questions: What similarities and differences exist between normal aging and disease-related neurodegeneration in terms of susceptibility to and effects of oxidative stress? How can oxidative stress or its effects be attenuated? Do antioxidants prevent or slow the progress of the disease? Is there any role for natural micronutrients in the attenuation of oxidative stress and prevention of age-related neurodegeneration? Some chapters look at the various ways research is getting to the core of neurodegenerative disease, including the use of proteomics, comparisons to related diseases, and examinations at the cellular and molecular levels. Other chapters focus on specific antioxidants and nutrients cited as being impactful, such as those found in Gingko biloba, green tea, blueberries, and grape seed extract. Researchers in academia, industry, and clinical medicine, as well as students and scholars will find use for this timely collection, either as an introduction to our current understanding of neurodegeneration or as a reference for further research. Clinicians will also benefit, as this book explains the basis for many of the latest approaches to prevention and therapy.

Metal Ions and Neurodegenerative Disorders

Metal Ions and Neurodegenerative Disorders
Author: Paolo Zatta
Publsiher: World Scientific
Total Pages: 538
Release: 2003
ISBN: 9812383980
Category: Medical
Language: EN, FR, DE, ES & NL

Metal Ions and Neurodegenerative Disorders Book Excerpt:

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena.Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on ?Metals and the Brain: From Neurochemistry to Neurodegeneration? (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa.This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy.

Antioxidants and Functional Foods for Neurodegenerative Disorders

Antioxidants and Functional Foods for Neurodegenerative Disorders
Author: Abhai Kumar,Debasis Bagchi
Publsiher: CRC Press
Total Pages: 472
Release: 2021-01-07
ISBN: 1000282740
Category: Health & Fitness
Language: EN, FR, DE, ES & NL

Antioxidants and Functional Foods for Neurodegenerative Disorders Book Excerpt:

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants – including vitamin D, tocotrienol and coenzyme Q10 – against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases.

Oxidative Stress in Vertebrates and Invertebrates

Oxidative Stress in Vertebrates and Invertebrates
Author: Tahira Farooqui,Akhlaq A. Farooqui
Publsiher: John Wiley & Sons
Total Pages: 416
Release: 2011-10-24
ISBN: 1118148118
Category: Science
Language: EN, FR, DE, ES & NL

Oxidative Stress in Vertebrates and Invertebrates Book Excerpt:

This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.

Oxidative Stress in Cancer Aids and Neurodegenerative Diseases

Oxidative Stress in Cancer  Aids  and Neurodegenerative Diseases
Author: Luc Montagnier,Rene Olivier,Catherine Pasquier
Publsiher: CRC Press
Total Pages: 576
Release: 2019-08-30
ISBN: 9780367400828
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Oxidative Stress in Cancer Aids and Neurodegenerative Diseases Book Excerpt:

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Oxidative Stress and Neurodegenerative Disorders

Oxidative Stress and Neurodegenerative Disorders
Author: G. Ali Qureshi,S. Hasan Parvez
Publsiher: Elsevier
Total Pages: 794
Release: 2007-03-22
ISBN: 9780080489490
Category: Science
Language: EN, FR, DE, ES & NL

Oxidative Stress and Neurodegenerative Disorders Book Excerpt:

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Oxidative Stress and Redox Signalling in Parkinson s Disease

Oxidative Stress and Redox Signalling in Parkinson   s Disease
Author: Rodrigo Franco,Jonathan A Doorn,Jean-Christophe Rochet
Publsiher: Royal Society of Chemistry
Total Pages: 537
Release: 2017-07-25
ISBN: 1782621881
Category: Medical
Language: EN, FR, DE, ES & NL

Oxidative Stress and Redox Signalling in Parkinson s Disease Book Excerpt:

Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders

Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders
Author: Amanda Wong
Publsiher: Unknown
Total Pages: 222
Release: 2001
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders Book Excerpt:

Role of Oxidative Stress in Pathophysiology of Diseases

Role of Oxidative Stress in Pathophysiology of Diseases
Author: Pawan K. Maurya,Kamal Dua
Publsiher: Springer Nature
Total Pages: 297
Release: 2020-06-15
ISBN: 9811515689
Category: Science
Language: EN, FR, DE, ES & NL

Role of Oxidative Stress in Pathophysiology of Diseases Book Excerpt:

This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.

Recent Advances in the Treatment of Neurodegenerative Disorders

Recent Advances in the Treatment of Neurodegenerative Disorders
Author: Sachchida Nand Rai
Publsiher: Bentham Science Publishers
Total Pages: 232
Release: 2021-04-26
ISBN: 1681087731
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances in the Treatment of Neurodegenerative Disorders Book Excerpt:

Researchers have tried various effective treatments that prevent the progressive neurodegeneration of neurons within the brain. Parkinson’s disease (PD), Alzheimer’s disease (AD), and Multiple sclerosis (MS) are some of the most common neurodegenerative diseases (NDDs). Recent Advances in the Treatment of Neurodegenerative Disorders provides interesting updates on treatments of these neurological disorders. Ten chapters have been contributed by experts in pharmacology and give a unique perspective to reader on special topics in this area, including the treatment of neurodegenerative treatment of neurodegenerative disease through ayurveda and phytochemicals, the therapeutic role of vitamins in Parkinson’s disease, mushrooms in NDD treatment, MS treatment, ALS treatment and the use of nanoparticles and nano formulations in NDD treatment. This is an informative reference for pharmacologists, medicinal chemists and healthcare professionals (general practitioners and neurologists) seeking updates in the treatment of some common neurodegenerative disorders.

The Role of Oxidative Stress in Neuronal Death

The Role of Oxidative Stress in Neuronal Death
Author: Irene Ceballos-Picot
Publsiher: Springer
Total Pages: 203
Release: 2013-10-03
ISBN: 9783662225189
Category: Medical
Language: EN, FR, DE, ES & NL

The Role of Oxidative Stress in Neuronal Death Book Excerpt:

This book examines current knowledge and recent advances in the study of fundamental processes involved in neuronal death, particularly oxidative stress as a causal agent or risk factor. The author presents discussion of oxidative stress in neuronal apoptosis and its role in the neuropathogenesis of age-related neurodegenerative diseases exemplified by Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis.

Metal Based Neurodegeneration

Metal Based Neurodegeneration
Author: Robert Crichton,Roberta Ward
Publsiher: John Wiley & Sons
Total Pages: 440
Release: 2013-09-04
ISBN: 1118553519
Category: Medical
Language: EN, FR, DE, ES & NL

Metal Based Neurodegeneration Book Excerpt:

Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a detailed surveyof the molecular origins of neurodegenerative diseases. Eachchapter is dedicated to a specific disease, presenting the latestscientific findings, including details of their biochemicalactors (proteins or peptides), their normal and pathologicalconformations, and a description of the diseases characteristics,with an emphasis on the role of metal-induced oxidative stress,which can result in the production of intracellular aggregates oftarget proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression ofneurological diseases This extensively updated, full colour, second edition ofMetal-based Neurodegeneration is an essential text forresearch scientists and clinicians working in gerontology,neuropathology, neurochemistry, and metalloprotein mechanisms.

Neurodegenerative Diseases

Neurodegenerative Diseases
Author: Uday Kishore
Publsiher: BoD – Books on Demand
Total Pages: 642
Release: 2013-05-15
ISBN: 9535110888
Category: Medical
Language: EN, FR, DE, ES & NL

Neurodegenerative Diseases Book Excerpt:

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders

Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders
Author: Preetham Elumalai,Sreeja Lakshmi
Publsiher: Springer Nature
Total Pages: 227
Release: 2022
ISBN: 9811667039
Category: Biology
Language: EN, FR, DE, ES & NL

Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders Book Excerpt:

This book provides a comprehensive summary of the latest knowledge regarding functional foods and new therapeutic strategies for neurodegenerative disorders through explaining specific mechanisms for natural remedies and functional foods as well as alternative treatment and supplementary approaches for neurodegenerative diseases. Many relevant topics are covered, including role of prebiotics, recent applications for dietary polyphenols, marine bioactive compounds for neuro disorders, and age-related disorders. The roles of various remedies and functional foods are explained for various types of diseases, and the book also integrates the role of functional foods and remedies to work with the current therapeutics that are taking place. In parallel, the information presented through this book will also stimulate current status of leading contemporary methods for prohylactic and diagnostic practices, comprising nanoparticles, biomarkers, in silico techniques, and CRISPR-mediated genome editing-based therapy. The book will be essential reading for students and researchers with an interest in natural medicine, drug development, and food therapeutic strategies. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.

Oxidative Stress Mechanisms and Disease Pathogenesis

Oxidative Stress  Mechanisms and Disease Pathogenesis
Author: Edwin Reynolds
Publsiher: Unknown
Total Pages: 203
Release: 2020-09-15
ISBN: 9781632418586
Category: Medical
Language: EN, FR, DE, ES & NL

Oxidative Stress Mechanisms and Disease Pathogenesis Book Excerpt:

Oxidative stress is an imbalance in the production of free radicals and the body's inability to counteract their harmful effects or detoxify. This imbalance can cause disruptions in cellular signaling. Oxidative stress implies an increased production of oxidizing species and decrease in the effectiveness of antioxidant defenses. Moderate oxidation can trigger apoptosis, while more severe cases cause necrosis. Oxidative stress is considered to be an important element in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Huntington's disease, Lou Gehrig's disease, multiple sclerosis, autism, etc. Oxidative stress has been implicated in the incidence of cardiovascular diseases, as oxidation of LDL is a precursor to plaque formation. This book elucidates the concepts and innovative models around prospective developments with respect to oxidative stress. It unravels the recent studies in the mechanisms and disease pathogenesis of oxidative stress. Coherent flow of topics, student-friendly language and extensive use of examples make this book an invaluable source of knowledge.

Current Trends in Medicinal Plant Research and Neurodegenerative Disorders

Current Trends in Medicinal Plant Research and Neurodegenerative Disorders
Author: Muhammad Ayaz,Tahir Ali,Abdul Sadiq,Farhat Ullah,Muhammad Imran Naseer
Publsiher: Frontiers Media SA
Total Pages: 206
Release: 2022-07-28
ISBN: 2889766330
Category: Science
Language: EN, FR, DE, ES & NL

Current Trends in Medicinal Plant Research and Neurodegenerative Disorders Book Excerpt:

Metal Ions in Neurological Systems

Metal Ions in Neurological Systems
Author: Wolfgang Linert,Henryk Kozlowski
Publsiher: Springer Science & Business Media
Total Pages: 247
Release: 2012-08
ISBN: 3709110009
Category: Medical
Language: EN, FR, DE, ES & NL

Metal Ions in Neurological Systems Book Excerpt:

Metal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically all neurodegenerative disorders by inducing disease via the death of neurons. Managing metal ions in the brain could therefore be an important strategy in the search for therapeutic agents used in the treatment of neurodegenerative diseases. This new title gives an overview to key topics in the area of metal ions in the brain. It focuses on the role of metal ions in neurological systems by describing their advantageous functions as well as their poisonous features. It is therefore of interest for scientists in biochemistry and biophysics, physiology, toxicology as well as for physicians focused on this topic.

Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases

Oxidative Stress in Cancer  AIDS  and Neurodegenerative Diseases
Author: Luc Montagnier,Rene Olivier,Catherine Pasquier
Publsiher: CRC Press
Total Pages: 576
Release: 1997-10-06
ISBN: 9780824798628
Category: Medical
Language: EN, FR, DE, ES & NL

Oxidative Stress in Cancer AIDS and Neurodegenerative Diseases Book Excerpt:

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

The Role of Antioxidants in Longevity and Age Related Diseases

The Role of Antioxidants in Longevity and Age Related Diseases
Author: Bee Ling Tan,Mohd Esa Norhaizan
Publsiher: Springer Nature
Total Pages: 295
Release: 2021-11-19
ISBN: 303082859X
Category: Family & Relationships
Language: EN, FR, DE, ES & NL

The Role of Antioxidants in Longevity and Age Related Diseases Book Excerpt:

The average life expectancy has increased worldwide in the recent decades. This has presented new challenges as old age brings the onset of diseases such as cancer, neurodegenerative disorders, cardiovascular disease, type 2 diabetes, arthritis, osteoporosis, stroke, and Alzheimer’s disease. Studies and research have shown the potential preventive and therapeutic roles of antioxidants in aging and age-related diseases by inhibiting the formation or disrupting the propagation of free radicals and thus increasing healthy longevity, enhancing immune function, and decreasing oxidative stress. This has made an antioxidant rich diet of increasing importance in battling the detrimental effects of the aging process. “The Role of Antioxidants in Longevity and Age-Related Diseases” is the book that compiles research on antioxidants and their biological mechanisms that mediate age-related diseases. This book covers the major issues linked to antioxidants, aging, and age-related diseases, including changes in organ systems over the lifespan, age-related oxidative stress-induced redox imbalance, inflammaging, implications of inflammation in aging and age-related diseases, and the important role of antioxidant-rich foods in their prevention and treatment of various age-related diseases. For researchers seeking a comprehensive single source on antioxidants and their roles in aging and age-related diseases, this novel text provides an up-to-date overview.

Natural Products and Brain Energy Metabolism Astrocytes in Neurodegenerative Diseases Volume I

Natural Products and Brain Energy Metabolism  Astrocytes in Neurodegenerative Diseases  Volume I
Author: Fushun Wang,Shijun Xu,Fang Pan,Jason H. Huang,Alexei Verkhratsky
Publsiher: Frontiers Media SA
Total Pages: 202
Release: 2022-11-11
ISBN: 2832505201
Category: Science
Language: EN, FR, DE, ES & NL

Natural Products and Brain Energy Metabolism Astrocytes in Neurodegenerative Diseases Volume I Book Excerpt: