Parkinsons Disease

Parkinson's disease (PD) is characterised by an insidious onset with slowing of emotional and voluntary movement, muscular rigidity, postural abnormality and tremor. Parkinson's disease was first described in 1817 by James Parkinson. It is a progressive, neurological disease mainly affecting people over the age of 50, although at least 10 per cent of cases occur at an earlier age. It affects people of either sex and all ethnic groups. In the normal brain, some nerve cells produce the chemical dopamine, which transmits signals within the brain to produce smooth movement of muscles. In Parkinson's patients, 80 percent or more of these dopamine-producing cells are damaged, dead, or otherwise degenerated. This causes the nerve cells to fire wildly, leaving patients unable to control their movements. This new book brings together the latest research in this field.

With the general population becoming increasingly aware of new developments for the diagnosis and treatment of certain neurological disorders throught increased media coverage in the popular press and on television and with celebrities being affected, the clinician must be aware of all the latest developments inthe diagnosis and treatment of disease. Parkinson's disease is no different. Peter LeWitt and Wolfgang Oertel have assembled an international team of contributors to write on their particular areas of expertise to produce a work which will help the practising clinician. This book captures all the latest information: the most important developments in the research of Parkinson's disease in recent years and the many different approaches to the treatment of the disease. These are exciting times for the study of Parkinson's disease, and this book condenses the wealth of available information into a practical text.

Written by an international group of renowned experts, the Fifth Edition of this premier reference provides comprehensive, current information on the genetics, pathophysiology, diagnosis, medical and surgical treatment, and behavioral and psychologic concomitants of all common and uncommon movement disorders. Coverage includes Parkinson's disease, other neurodegenerative diseases, tremors, dystonia, Tourette's syndrome, Huntington's disease, and ataxias. This edition features extensive updates on genetics, imaging, and therapeutics of Parkinson's disease, other parkinsonian disorders, and all hyperkinetic movement disorders. A bound-in CD-ROM, Video Atlas of Movement Disorders, demonstrates the movement and posture abnormalities and other disturbances associated with Parkinson's disease and other neurologic disorders.

It is an insidious illness with no known cure, afflicting those who suffer from it with near-uncontrollable tremors, speech impairment, and balance problems. In addition, one's intelligence experiences decline. Among its most prominent victims are Muhammad Ali and Michael J Fox. Parkinson's disease is a disorder of certain nerve cells in the brain that produce dopamine, which is a chemical messenger that the brain uses to help direct and control movement. In Parkinson's disease, these dopamine-producing nerve cells break down, dopamine levels drop, and brain signals directing movement become abnormal. Usually, the disease begins in later life (in one's 50s or after), although there are cases of 'early-onset' Parkinson's affecting those in their 20s and 30s. Medical science has yet to determine a cause for this illness, although recent tests have seemed to rule out genetics. In addition, there is no known cure, but treatment can lessen some of the symptoms. The importance of understanding Parkinson's disease is quite clear, and medical research in the field is moving ahead, although there are continual battles for funding. across the world. After giving a thorough overview of Parkinson's, the book gives a carefully selected list of abstracts of relevant literature, then provides easy access via author, title, and subject indexes.

Parkinson’s disease is on the rise throughout the U.S., and this book offers readers an introduction to its causes, symptoms, and treatments. It is for anyone who suffers from Parkinson’s, or knows and loves someone who does.

Parkinson's disease is no longer considered only a motor disorder. It has become evident that the pathological changes are broad, the progression seems to follow a pattern suggesting transynaptic transmission via templation of proteins in a prion-like fashion, and that these pathological changes usually antedate the motor symptoms by decades. This book emphasizes treatment options for Parkinson's disease, critically assessing pharmacologic and surgical interventions for all aspects of the disease. Evidence from randomized controlled clinical trials is highlighted to develop practical recommendations for clinical practice. Lessons learnt from clinical trials – and controversies and future challenges – are all addressed. Readers will find the necessary clinical and scientific foundations for the understanding of the disease, the underpinnings of the pathological processes, the identification of disease biomarkers, and the basis for solid therapeutics. Chapters are authored by an international team of specialists who bring their expertise to improving the management of this disease.

"1. Introduction Non-motor symptoms (NMS) are a crucial component of Parkinson's disease (PD) and the burden of the range of NMS that occurs in PD is one of the main determinants of quality of life [1]. In 1817, Dr James Parkinson already described several NMS in his "shaking palsy", the condition that would later be named after him, including pain, constipation and sleep disturbances [2]. Nonetheless, after a long period of inertia, over the last 20 to 25 years the interest in NMS has increased and evidence suggests that the overall burden of NMS dominates and can influence the risk of developing motor parkinsonism in the premotor stage of PD while being a driving factor for quality of life [3]. The identification of NMS in PD has been greatly aided by the development of specific tools, such as the NMS questionnaire (NMSQ) in 2006 [4] and the NMS Scale (NMSS) in 2007 [5]. The NMSS, which was based on the previously validated NMSQ, addresses a wide range of NMS in PD which are grouped into nine domains, measured over the period of the last month and quantified by severity and frequency (NMS symptomatic burden) [5]. Recently, a new version of the NMSS, the Movement Disorder society - Non-motor symptoms scale (MDS-NMS), has been published which will further aid in the identification and quantification on NMS burden of PD [6]. In this chapter, we will describe the phenomenology of NMS in PD, including non-motor fluctuations (NMF), and how to measure these symptoms"--

Highly Commended, BMA Medical Book Awards 2014This volume has long prevailed as one of the leading resources on Parkinson's disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatme

'Neurorehabilitation in Parkinson's Disease' serves as a reference for the treatment of patients with Parkinson's disease. In addition to providing treatment models for physical therapy, occupational therapy, & speech-language pathology, the text covers topics such as review of pathophysiology, & symptomatology.

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Cognition in Parkinson's Disease, Volume 269 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cognition in Prodromal Parkinson’s disease, The epidemiology of cognitive function in Parkinson's disease, Real-life consequences of cognitive dysfunction in Parkinson’s disease, Animal models of cognition in Parkinson’s disease, Functional neuroanatomy of cognition in Parkinson’s disease, Neuroimaging approaches to cognition in Parkinson’s disease, Cognitive dysfunction and neuropsychiatric aspects of Parkinson’s disease, Neuropsychology of Parkinson’s disease, Cholinergic Systems, Attentional-Motor Integration, and Cognitive Control in Parkinson Disease, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Brain Research series Updated release includes the latest information on Cognition in Parkinson's Disease

The Neuroscience of Parkinson’s Disease (two volume set) provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. The book also fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease

"Parkinson's Disease in the Older Patient, Second Edition" has been fully revised, updated and expanded to include new treatments and entirely new chapters. This authoritative text is written by recognised national specialists in the field and provides accessible, easy-to-read information. The practical and versatile approach comprehensively covers all aspects of treatment, and although it focuses on the older patient, it is also highly relevant for younger patient groups with an emphasis on multidisciplinary assessment and management. Detailed information on the aetiology and pathogenesis of the condition, drug and surgical treatments, sleep disturbances, quality of life and careers is now included, along with the more prevalent older patient issues such as neuropsychiatric disturbances, speech and swallowing problems, balance and falls, and autonomic disturbances. The updates also include new advice on the management and services in primary care, linked to the recent NICE guidelines.With official endorsement from The Parkinson's Disease Academy of the British Geriatrics Society, this new edition is highly recommended for general practitioners, geriatricians, neurologists and psychiatrists. Physiotherapists, occupational therapists, speech therapists, dieticians, and psychologists will also find it invaluable. It is suitable for general and specialist nurses, and will be of great use to researchers with an interest in Parkinson's disease.

Diagnosis and Management in Parkinson's Disease: The Neuroscience of Parkinson’s, Volume 1 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything concerning the neurology and neuroscience related to Parkinson’s disease, from chemicals and cells to individuals. The book is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease

Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Still the only major text on the subject, the completely revised and updated second edition of Parkinson's Disease: Diagnosis and Clinical Management comes at a time when specialists have made important advances in our understanding of the etiology, pathogenesis, investigation, and management of Parkinson's disease. The book includes 23 completely new chapters, and has updated information on: Genetics Pathology Biomarkers Pathogenesis Impulse control disorders in Parkinson's disease Updated outcome measures Complementary and alternative medicine for the treatment of Parkinson's disease Together the chapters form a comprehensive review of the many issues facing PD physicians today. Lucid and easily readable from beginning to end, each chapter may also stand on its own as a scholarly review of the individual subject. Each one is concisely written and heavily referenced for this purpose. The second edition of Parkinson's Disease: Diagnosis and Clinical Management provides a state-of-the-art review of where we've been, where we are now, and where we are going in treating this disease.

Psychiatric symptoms are common in the neurological and geriatric care of patients with Parkinson’s disease. This book assembles short reviews from experts in the field to chart the various psychiatric syndromes known in Parkinson’s disease, their presentation, etiology and management. Presented are special topics on epidemiology of psychiatric symptoms, affective disorders and apathy, early cognitive impairment through to dementia, visuoperceptual dysfunction, psychotic disorders, sleep disturbances, impulse disorders and sexual problems. Further, rarely discussed issues, such as the relationship between somatoform disorders and parkinsonism are reviewed.This publication is essential reading for old age psychiatrists, gerontologists and neurologists who work with patients suffering from Parkinson’s disease. In addition, health practitioners who deal with senior patients, as well as scientists who need a quick update on the progress in this important clinical field will find this volume a helpful reference.

Evidence shows that a multidisciplinary approach to Parkinson’s care provides better patient outcomes and is more cost effective. This new title provides a practical guide to this approach, with the perspective of the person living with Parkinson’s firmly at its core. Written by experts in their field and firmly grounded in up-to-date evidence, Parkinson’s Disease: A Multidisciplinary Guide to Management addresses multidisciplinary intervention through the various stages of disease, rather than by discipline. It covers all aspects of care, from pharmacological management to non-drug interventions that are helpful for Parkinson’s symptoms. This book is unique in its holistic approach to the patient and their family, and will help all members of the team to implement a biopsychosocial model of health that puts the person with Parkinson’s at the centre of care. Clinician-led content provides perspectives of different members of the interdisciplinary team, including medics, nurses, physiotherapists, occupational therapists and psychologists Includes practical advice and top tips enhance management of common problems Includes best practice for Parkinson’s as well as Atypical Parkinsonian Syndromes - Progressive Supranuclear Palsy, Corticobasal Syndrome and Multiple System Atrophy Includes management of falls and bone health, palliative care, management of inpatients Provides practical advice on delivering services remotely by telephone or video