Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
Author: Francisco J. Alvarez-Leefmans,Eric Delpire
Publsiher: Academic Press
Total Pages: 617
Release: 2009
ISBN: 9780123743732
Category: Medical
Language: EN, FR, DE, ES & NL

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Book Excerpt:

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases.

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System
Author: F. Javier Alvarez-Leefmans,Eric Delpire
Publsiher: Academic Press
Total Pages: 630
Release: 2009-08-22
ISBN: 9780080922034
Category: Medical
Language: EN, FR, DE, ES & NL

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System Book Excerpt:

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

Cell Physiology Source Book

Cell Physiology Source Book
Author: Nicholas Sperelakis,Nick Sperelakis
Publsiher: Academic Press
Total Pages: 997
Release: 2012-01-11
ISBN: 0123877385
Category: Science
Language: EN, FR, DE, ES & NL

Cell Physiology Source Book Book Excerpt:

Cell Physiology Source Book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The 4e contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, and synaptic transmission. Authored by leading researchers in the field Clear, concise, and comprehensive coverage of all aspects of cellular physiology, from fundamental concepts to more advanced topics Full color illustrations

Neuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease
Author: Xin Tang
Publsiher: Academic Press
Total Pages: 766
Release: 2020-06-19
ISBN: 0128153199
Category: Medical
Language: EN, FR, DE, ES & NL

Neuronal Chloride Transporters in Health and Disease Book Excerpt:

In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters. Neuronal chloride transporter biology is reviewed, including roles in setting the transmembrane chloride gradient and the chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters are also dedicated to addressing the structure, post-translational modification, membrane trafficking, and protein interaction partners of neuronal chloride transporters, as well as the genetic and environmental factors that regulate their expression in neurons and the novel therapeutic approaches that target neuronal chloride transporters to treat neurological diseases. This new volume will provide readers with an up-to-date summary of the recent advances in neuronal chloride transporter research, with particular emphasis on some of the key emerging topics in the field. Summarizes roles of KCCs and NKCCs in regulating inhibitory and excitatory neurotransmission Reviews the molecular and cellular biology of neuronal chloride transporters Links neuronal chloride transporter deficiencies to autism, epilepsy, depression, and more Identifies role of transporter deficiencies in pain as well as brain and spinal cord injury Discusses drug research targeting neuronal chloride transporters for nervous system diseases

Ion Transport Across Epithelial Tissues and Disease

Ion Transport Across Epithelial Tissues and Disease
Author: Kirk L. Hamilton,Daniel C. Devor
Publsiher: Springer Nature
Total Pages: 382
Release: 2020-12-12
ISBN: 3030553108
Category: Medical
Language: EN, FR, DE, ES & NL

Ion Transport Across Epithelial Tissues and Disease Book Excerpt:

This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.

Erythrocytes

Erythrocytes
Author: Florian Lang,Michael Föller
Publsiher: World Scientific Publishing Company
Total Pages: 452
Release: 2012-07-23
ISBN: 1908977086
Category: Medical
Language: EN, FR, DE, ES & NL

Erythrocytes Book Excerpt:

The book covers the functional significance and properties of erythrocytes, their generation, senescence, and suicidal death. It further summarizes knowledge about hormones influencing erythrocyte formation including erythropoietin as well as disorders affecting and involving erythrocytes such as anemia, malaria, and sepsis. This seminal work forms a unique reference on the most abundant cell type in mammals and will be an invaluable resource for students in the life sciences.

Cell Volume Regulation

Cell Volume Regulation
Author: Anonim
Publsiher: Academic Press
Total Pages: 514
Release: 2018-09-20
ISBN: 0128154578
Category: Science
Language: EN, FR, DE, ES & NL

Cell Volume Regulation Book Excerpt:

Cell Volume Regulation and Fluid Secretion, Volume 81, the latest release in the Current Topics in Membranes series highlights new advances in the field, with this new volume presenting interesting chapters on General principles of cell volume regulation, Cell volume maintenance: water and salt homeostasis, The search for ubiquitous cell volume sensor: the role of plasma membrane and cytoplasmic hydrogel, More than membranes, Cellular and membrane biomechanics of CVR response, Molecular identities of volume-regulatory anion channels, Molecular biology and physiology of volume-regulated anion channel (VRAC), the Role of WNKs in the modulation of intracellular chloride, amongst other topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on Cell Volume Regulation

Ion Channels and Transporters of Epithelia in Health and Disease

Ion Channels and Transporters of Epithelia in Health and Disease
Author: Kirk L. Hamilton,Daniel C Devor
Publsiher: Springer
Total Pages: 1019
Release: 2015-12-14
ISBN: 1493933663
Category: Medical
Language: EN, FR, DE, ES & NL

Ion Channels and Transporters of Epithelia in Health and Disease Book Excerpt:

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.

Encyclopedia of the Neurological Sciences

Encyclopedia of the Neurological Sciences
Author: Anonim
Publsiher: Academic Press
Total Pages: 4740
Release: 2014-04-29
ISBN: 0123851580
Category: Medical
Language: EN, FR, DE, ES & NL

Encyclopedia of the Neurological Sciences Book Excerpt:

The Encyclopedia of the Neurological Sciences, Second Edition develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index

Nanomaterials for Drug Delivery and Therapy

Nanomaterials for Drug Delivery and Therapy
Author: Alexandru Mihai Grumezescu
Publsiher: William Andrew
Total Pages: 580
Release: 2019-03-14
ISBN: 0128166290
Category: Medical
Language: EN, FR, DE, ES & NL

Nanomaterials for Drug Delivery and Therapy Book Excerpt:

Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug delivery and treatment solutions. It is a valuable research resource that will help both practicing medics and researchers in pharmaceutical science and nanomedicine learn more on how nanotechnology is improving treatments. Assesses the opportunities and challenges of nanotechnology-based drug delivery systems Explores how nanotechnology is being used to create more efficient drug delivery systems Discusses which nanomaterials make the best drug carriers

Metalloenzymes Potential Drug Targets

Metalloenzymes  Potential Drug Targets
Author: Jamshed Iqbal,Jean Sévigny,Claus Jacob
Publsiher: Frontiers Media SA
Total Pages: 145
Release: 2021-11-12
ISBN: 2889716279
Category: Science
Language: EN, FR, DE, ES & NL

Metalloenzymes Potential Drug Targets Book Excerpt:

Basic Epithelial Ion Transport Principles and Function

Basic Epithelial Ion Transport Principles and Function
Author: Kirk L. Hamilton,Daniel C. Devor
Publsiher: Springer Nature
Total Pages: 563
Release: 2020-11-26
ISBN: 3030527808
Category: Medical
Language: EN, FR, DE, ES & NL

Basic Epithelial Ion Transport Principles and Function Book Excerpt:

This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.

Otolaryngology

Otolaryngology
Author: Balwant Singh Gendeh
Publsiher: BoD – Books on Demand
Total Pages: 212
Release: 2012-05-23
ISBN: 9535106244
Category: Medical
Language: EN, FR, DE, ES & NL

Otolaryngology Book Excerpt:

This book emphasizes on different aspects of otolaryngology - the medical sciences of diagnosis and treatment of ENT disorders. "Otolaryngology" is divided into various clinical sub-specialities, namely otology, rhinology, laryngology, and head and neck. This book incorporates new developments, as well as future perspectives in otolaryngology. I would like to dedicate this book to those of you who will pick up the torch and by continued research, close clinical observation and the highest quality of clinical care, as well as by publication and selfless teaching, further advance knowledge in otolaryngology from this point forward. It is intended to be a guide to other books to follow. Otolaryngologists, researches, specialists, trainees, and general practitioners with interest in otolaryngology will find this book interesting and useful.

Oxford Handbook of Auditory Science The Ear

Oxford Handbook of Auditory Science  The Ear
Author: Paul Fuchs
Publsiher: OUP Oxford
Total Pages: 462
Release: 2010-01-14
ISBN: 019923339X
Category: Science
Language: EN, FR, DE, ES & NL

Oxford Handbook of Auditory Science The Ear Book Excerpt:

The first volume in The Oxford Handbook of Auditory Science, The Ear serves both as an introduction and as a reference work for anyone interested in how 'hearing' happens. It will be a valuable resource, for anyone interested in the ongoing challenge, and adventure, of understanding the mysteries of the ear.

XXVI Brazilian Congress on Biomedical Engineering

XXVI Brazilian Congress on Biomedical Engineering
Author: Rodrigo Costa-Felix,João Carlos Machado,André Victor Alvarenga
Publsiher: Springer
Total Pages: 891
Release: 2019-05-15
ISBN: 9811325170
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

XXVI Brazilian Congress on Biomedical Engineering Book Excerpt:

This volume presents the proceedings of the Brazilian Congress on Biomedical Engineering (CBEB 2018). The conference was organised by the Brazilian Society on Biomedical Engineering (SBEB) and held in Armação de Buzios, Rio de Janeiro, Brazil from 21-25 October, 2018. Topics of the proceedings include these 11 tracks: • Bioengineering • Biomaterials, Tissue Engineering and Artificial Organs • Biomechanics and Rehabilitation • Biomedical Devices and Instrumentation • Biomedical Robotics, Assistive Technologies and Health Informatics • Clinical Engineering and Health Technology Assessment • Metrology, Standardization, Testing and Quality in Health • Biomedical Signal and Image Processing • Neural Engineering • Special Topics • Systems and Technologies for Therapy and Diagnosis

Practical Management of Pain E Book

Practical Management of Pain E Book
Author: Honorio MD Benzon,James P. Rathmell,Christopher L. Wu,Dennis C. Turk,Charles E. Argoff,Robert W Hurley
Publsiher: Elsevier Health Sciences
Total Pages: 1520
Release: 2022-02-10
ISBN: 0323711022
Category: Medical
Language: EN, FR, DE, ES & NL

Practical Management of Pain E Book Book Excerpt:

For more than 30 years, Practical Management of Pain has offered expert guidance to both clinicians and trainees, covering every aspect of acute and chronic pain medicine for adult and pediatric patients. The fully revised 6th Edition brings you fully up to date with new developments in patient evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. Edited by a team of renowned pain clinicians led by Dr. Honorio Benzon, this authoritative reference is a comprehensive, practical resource for pain diagnosis and treatment using a variety of pharmacologic and physical modalities. Presents a wealth of information in a clearly written, easily accessible manner, enabling you to effectively assess and draw up an optimal treatment plan for patients with acute or chronic pain. Takes a practical, multidisciplinary approach, making key concepts and techniques easier to apply to everyday practice. Shares the knowledge and expertise of global contributors on all facets of pain management, from general principles to specific management techniques. Discusses the latest, best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents such as topical analgesics. Covers recent global developments regarding opioid induced hyperalgesia, neuromodulation and pain management, and identification of specific targets for molecular based pain. Includes current information on the use of cannabinoids in pain management and related regulatory, professional, and legal considerations. Includes the latest guidelines on facet injections and safety of contrast agents. Provides new, evidence-based critical analysis on treatment modality outcomes and the latest information on chronic pain as a result of surgical interventions.

Neurological Outcomes in Preterm Infants Current Controversies and Therapies for Brain Injury

Neurological Outcomes in Preterm Infants     Current Controversies and Therapies for Brain Injury
Author: Carina Mallard,Mary Tolcos,Justin Dean
Publsiher: Frontiers Media SA
Total Pages: 445
Release: 2020-02-10
ISBN: 2889634949
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Neurological Outcomes in Preterm Infants Current Controversies and Therapies for Brain Injury Book Excerpt:

Preterm birth affects over 15 million newborns worldwide each year and is the main contributor of neonatal mortality and morbidity. While neonatal survival following preterm birth continues to improve, this has not been matched by a decline in neurological outcome. There is still a high prevalence of motor problems, executive dysfunction, and cognitive impairment in infants born preterm. Improved neuroimaging has helped to describe different types of neonatal brain injuries in this population and has given a better understanding of underlying pathogenesis. However, therapies are still lacking and there is a great need to find novel strategies to improve injury and functional outcome.

The British National Bibliography

The British National Bibliography
Author: Arthur James Wells
Publsiher: Unknown
Total Pages: 135
Release: 2009
ISBN: 1928374650XXX
Category: Bibliography, National
Language: EN, FR, DE, ES & NL

The British National Bibliography Book Excerpt:

Guyton Hall Textbook of Medical Physiology 3rd SAE E book

Guyton   Hall Textbook of Medical Physiology 3rd SAE E book
Author: Mario Vaz,Anura Kurpad,Tony Dr. Raj
Publsiher: Elsevier Health Sciences
Total Pages: 1070
Release: 2020-07-25
ISBN: 8131257746
Category: Medical
Language: EN, FR, DE, ES & NL

Guyton Hall Textbook of Medical Physiology 3rd SAE E book Book Excerpt:

Chapters have been rearranged and often split to work towards one chapter-one lecture model so that the text is linked to curriculum objectives which appeals to both students and faculty. Narrative length has been reduced while ensuring the original flow and explanation of concepts is not affected. Updated Learning Objectives (e.g. Applied physiology of the Renal System) and Glossary of Terms in the beginning of every chapter. Short, easy-to-read, masterfully edited chapters and a user-friendly full-color design facilitates better learning and retention. Features expanded clinical coverage including obesity, metabolic and cardiovascular disorders, Alzheimer’s disease, and other degenerative diseases. Complex Concepts/Processes are summarized in flowcharts/flow diagram for better understanding. Contains more than 1000 carefully crafted diagrams and drawings ensures better understanding of Physiology. Offers Clinically Oriented perspective - bridging basic physiology with pathophysiology, including cellular and molecular mechanism important for Clinical medicine. Updated throughout based on the Guyton and Hall Textbook of Physiology 14th edition to reflect the latest knowledge in the field. The information of the book has been updated to include all areas of the new MCI curriculum (these are either embedded within the existing chapters or as several new chapters at the end of the book).

Guyton Hall Textbook of Medical Physiology E Book

Guyton   Hall Textbook of Medical Physiology   E Book
Author: Mario Vaz,Tony Raj,Anura Kurpad
Publsiher: Elsevier Health Sciences
Total Pages: 930
Release: 2016-07-22
ISBN: 8131246655
Category: Medical
Language: EN, FR, DE, ES & NL

Guyton Hall Textbook of Medical Physiology E Book Book Excerpt:

Chapters have been rearranged and often split to work towards one chapter-one lecture model. Learning objectives and glossary of terms in the begining of every chapter. 56 Videos and animations 120 Multiple choice questions The main aim of the Second South Asia Edition is to meet the needs of the undergraduate medical students and faculty on South Asia by aligning the book to the teaching menthods in the subcontinent.