Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure
Author: Stephen Neidle,Mark Sanderson
Publsiher: Elsevier
Total Pages: 454
Release: 2021-10-14
ISBN: 0128196777
Category: Science
Language: EN, FR, DE, ES & NL

Principles of Nucleic Acid Structure Book Excerpt:

Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results. Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge Defines technical terms for novices Includes a complete list of resources, including relevant online databases and software, as well as useful websites

Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure
Author: Wolfram Saenger
Publsiher: Unknown
Total Pages: 556
Release: 1984
ISBN: 9783540907626
Category: Acides nucléiques
Language: EN, FR, DE, ES & NL

Principles of Nucleic Acid Structure Book Excerpt:

Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure
Author: Stephen Neidle
Publsiher: Elsevier
Total Pages: 302
Release: 2010-07-26
ISBN: 9780080553528
Category: Science
Language: EN, FR, DE, ES & NL

Principles of Nucleic Acid Structure Book Excerpt:

This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software. Completely updated with expanded discussion of topics such as RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA) Includes a complete list of resources, including relevant online databases and software Defines technical lingo for novices

Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure
Author: Wolfram Saenger,Martin Egli
Publsiher: Springer
Total Pages: 584
Release: 1984
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Principles of Nucleic Acid Structure Book Excerpt:

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.

Basic Principles in Nucleic Acid Chemistry

Basic Principles in Nucleic Acid Chemistry
Author: Paul On Pong Ts'o
Publsiher: Unknown
Total Pages: 544
Release: 1974
ISBN: 1928374650XXX
Category: Nucleic acids
Language: EN, FR, DE, ES & NL

Basic Principles in Nucleic Acid Chemistry Book Excerpt:

Basic Principles in Nucleic Acid Chemistry V2 ...

Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure
Author: Stephen Neidle,Mark Sanderson
Publsiher: Academic Press
Total Pages: 454
Release: 2021-10-29
ISBN: 0128196785
Category: Science
Language: EN, FR, DE, ES & NL

Principles of Nucleic Acid Structure Book Excerpt:

Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results. • Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge • Defines technical terms for novices • Includes a complete list of resources, including relevant online databases and software, as well as useful websites

Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure
Author: Wolfram Saenger
Publsiher: Springer Science & Business Media
Total Pages: 556
Release: 2013-12-01
ISBN: 1461251907
Category: Science
Language: EN, FR, DE, ES & NL

Principles of Nucleic Acid Structure Book Excerpt:

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.

Physical Principles in Nucleic Acid Chemistry

Physical Principles in Nucleic Acid Chemistry
Author: David E. Draper
Publsiher: CRC PressI Llc
Total Pages: 450
Release: 2014-12-15
ISBN: 9781466571280
Category: Medical
Language: EN, FR, DE, ES & NL

Physical Principles in Nucleic Acid Chemistry Book Excerpt:

Nucleic Acid Structure and Recognition

Nucleic Acid Structure and Recognition
Author: Stephen Neidle
Publsiher: Oxford University Press, USA
Total Pages: 212
Release: 2002
ISBN: 9780198506355
Category: Science
Language: EN, FR, DE, ES & NL

Nucleic Acid Structure and Recognition Book Excerpt:

This is a postgraduate text on the structure of nucleic acids and the functional role played by structure in the recognition of nucleic acids by proteins, drugs and carcinogens.

RNA Structure and Function

RNA Structure and Function
Author: Robert W. Simons,Marianne Grunberg-Manago
Publsiher: Unknown
Total Pages: 764
Release: 1998
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

RNA Structure and Function Book Excerpt:

The striking functional versatility of RNA is attributable to its remarkable capacity for conformational change. Current models of RNA synthesis, its maturation, translation and degradation are all based on specific structures and there is growing appreciation of the functional importance of interactions between RNA and RNA-binding proteins. This work identifies the major intellectual and technical advances in understanding the part played by structure in how RNA works. It encompasses the experimental approaches used to define RNA structure and its influence on RNA functions such as transcription termination, catalysis, recoding and translational control. Investigators with these interests and students of molecular biology should find this volume a provocative survey of a rapidly-advancing field and a valuable complement to the monograph, The RNA World.

Nucleic Acids in Chemistry and Biology

Nucleic Acids in Chemistry and Biology
Author: G. Michael Blackburn,Michael J. Gait,David M. Williams,David Loakes
Publsiher: Royal Society of Chemistry
Total Pages: 503
Release: 2006
ISBN: 0854046542
Category: Science
Language: EN, FR, DE, ES & NL

Nucleic Acids in Chemistry and Biology Book Excerpt:

Discussing both the chemistry and biology of nucleic acids, this edition also provides coverage of nucleic acid chemistry and reactions and interactions with proteins and drugs.

Protein Nucleic Acid Interactions

Protein Nucleic Acid Interactions
Author: Phoebe A. Rice,Carl C. Correll
Publsiher: Royal Society of Chemistry
Total Pages: 417
Release: 2008-05-22
ISBN: 0854042725
Category: Science
Language: EN, FR, DE, ES & NL

Protein Nucleic Acid Interactions Book Excerpt:

The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. New insights are now being gained from comparative studies only recently made possible due to the size of the database, as well as from careful biochemical and biophysical studies. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review. Instead, current review articles tend to focus on particular subtopics of interest. This makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic acid interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also aims to bridge the gap between the DNA- and the RNA- views of nucleic acid - protein recognition, which are often treated as separate fields. However, this is a false dichotomy because protein - DNA and protein - RNA interactions share many general principles. This book therefore includes relevant examples from both sides, and frames discussions of the fundamentals in terms that are relevant to both. The monograph approaches the study of protein-nucleic acid interactions in two distinctive ways. First, DNA-protein and RNA-protein interactions are presented together. Second, the first half of the book develops the principles of protein-nucleic acid recognition, whereas the second half applies these to more specialized topics. Both halves are illustrated with important real life examples. The first half of the book develops fundamental principles necessary to understand function. An introductory chapter by the editors reviews the basics of nucleic acid structure. Jen-Jacobsen and Jacobsen discuss how solvent interactions play an important role in recognition, illustrated with extensive thermodynamic data on restriction enzymes. Marmorstein and Hong introduce the zoology of the DNA binding domains found in transcription factors, and describe the combinational recognition strategies used by many multiprotein eukaryotic complexes. Two chapters discuss indirect readout of DNA sequence in detail: Berman and Lawson explain the basic principles and illustrate them with in-depth studies of CAP, while in their chapter on DNA bending and compaction Johnson, Stella and Heiss highlight the intrinsic connections between DNA bending and indirect readout. Horvath lays out the fundamentals of protein recognition of single stranded DNA and single stranded RNA, and describes how they apply in a detailed analysis of telomere end binding proteins. Nucleic acids adopt more complex structures - Lilley describes the conformational properties of helical junctions, and how proteins recognize and cleave them. Because RNA readily folds due to the stabilizing role of its 2'-hydroxyl groups, Li discusses how proteins recognize different RNA folds, which include duplex RNA. With the fundamentals laid out, discussion turns to more specialized examples taken from important aspects of nucleic acid metabolism. Schroeder discusses how proteins chaperone RNA by rearranging its structure into a functional form. Berger and Dong discuss how topoisomerases alter the topology of DNA and relieve the superhelical tension introduced by other processes such as replication and transcription. Dyda and Hickman show how DNA transposes mediate genetic mobility and Van Duyne discusses how site-specific recombinases cut and paste DNA. Horton presents a comprehensive review of the structural families and chemical mechanisms of DNA nucleases, whereas Li in her discussion of RNA-protein recognition also covers RNA nucleases. Lastly, FerrÚ-D'AmarÚ shows how proteins recognize and modify RNA transcripts at specific sites. The book also emphasises the impact of structural biology on understanding how proteins interact with nucleic acids and it is intended for advanced students and established scientists wishing to broaden their horizons.

Ribozymes 2 Volume Set

Ribozymes  2 Volume Set
Author: Sabine Müller,Benoît Masquida,Wade Winkler
Publsiher: John Wiley & Sons
Total Pages: 81
Release: 2021-10-18
ISBN: 3527344543
Category: Science
Language: EN, FR, DE, ES & NL

Ribozymes 2 Volume Set Book Excerpt:

Ribozymes Provides comprehensive coverage of a core field in the molecular biosciences, bringing together decades of knowledge from the world’s top professionals in the field Timely and unique in its breadth of content, this all-encompassing and authoritative reference on ribozymes documents the great diversity of nucleic acid-based catalysis. It integrates the knowledge gained over the past 35 years in the field and features contributions from virtually every leading expert on the subject. Ribozymes is organized into six major parts. It starts by describing general principles and strategies of nucleic acid catalysis. It then introduces naturally occurring ribozymes and includes the search for new catalytic motifs or novel genomic locations of known motifs. Next, it covers the development and design of engineered ribozymes, before moving on to DNAzymes as a close relative of ribozymes. The next part examines the use of ribozymes for medicinal and environmental diagnostics, as well as for therapeutic tools. It finishes with a look at the tools and methods in ribozyme research, including the techniques and assays for structural and functional characterization of nucleic acid catalysts. The first reference to tie together all aspects of the multi-faceted field of ribozymes Features more than 30 comprehensive chapters in two volumes Covers the chemical principles of RNA catalysis; naturally occurring ribozymes, engineered ribozymes; DNAzymes; ribozymes as tools in diagnostics and therapy, and tools and methods to study ribozymes Includes first-hand accounts of concepts, techniques, and applications by a team of top international experts from leading academic institutions Dedicates half of its content to methods and practical applications, ranging from bioanalytical tools to medical diagnostics to therapeutics Ribozymes is an unmatched resource for all biochemists, biotechnologists, molecular biologists, and bioengineers interested in the topic.

Ribozymes

Ribozymes
Author: Sabine Müller,Benoît Masquida,Wade Winkler
Publsiher: John Wiley & Sons
Total Pages: 944
Release: 2021-07-09
ISBN: 3527814531
Category: Science
Language: EN, FR, DE, ES & NL

Ribozymes Book Excerpt:

Ribozymes Provides comprehensive coverage of a core field in the molecular biosciences, bringing together decades of knowledge from the world’s top professionals in the field Timely and unique in its breadth of content, this all-encompassing and authoritative reference on ribozymes documents the great diversity of nucleic acid-based catalysis. It integrates the knowledge gained over the past 35 years in the field and features contributions from virtually every leading expert on the subject. Ribozymes is organized into six major parts. It starts by describing general principles and strategies of nucleic acid catalysis. It then introduces naturally occurring ribozymes and includes the search for new catalytic motifs or novel genomic locations of known motifs. Next, it covers the development and design of engineered ribozymes, before moving on to DNAzymes as a close relative of ribozymes. The next part examines the use of ribozymes for medicinal and environmental diagnostics, as well as for therapeutic tools. It finishes with a look at the tools and methods in ribozyme research, including the techniques and assays for structural and functional characterization of nucleic acid catalysts. The first reference to tie together all aspects of the multi-faceted field of ribozymes Features more than 30 comprehensive chapters in two volumes Covers the chemical principles of RNA catalysis; naturally occurring ribozymes, engineered ribozymes; DNAzymes; ribozymes as tools in diagnostics and therapy, and tools and methods to study ribozymes Includes first-hand accounts of concepts, techniques, and applications by a team of top international experts from leading academic institutions Dedicates half of its content to methods and practical applications, ranging from bioanalytical tools to medical diagnostics to therapeutics Ribozymes is an unmatched resource for all biochemists, biotechnologists, molecular biologists, and bioengineers interested in the topic.

Topics in Nucleic Acid Structure

Topics in Nucleic Acid Structure
Author: Stephen Neidle
Publsiher: Springer
Total Pages: 221
Release: 1981-06-18
ISBN: 1349046914
Category: Science
Language: EN, FR, DE, ES & NL

Topics in Nucleic Acid Structure Book Excerpt:

Comprehensive Supramolecular Chemistry Supramolecular reactivity and transport bioinorganic systems

Comprehensive Supramolecular Chemistry  Supramolecular reactivity and transport   bioinorganic systems
Author: Multiple Contributors
Publsiher: Elsevier
Total Pages: 410
Release: 1996-07-16
ISBN: 9780080427171
Category: Science
Language: EN, FR, DE, ES & NL

Comprehensive Supramolecular Chemistry Supramolecular reactivity and transport bioinorganic systems Book Excerpt:

Comprehensive Supramolecular Chemistry covers for the first time in eleven detailed volumes the exciting inter- and multidisciplinary area of modern supramolecular chemistry. This subject, which has now reached an astonishing diversity and complexity, has developed at a remarkably rapid pace following the initial discoveries of crown ethers and cryptands in the late sixties. The numerous references, including many recent citations, constitute an unrivalled in-depth source for direct entry to the widespread primary literature on any aspect of this most highly topical area. The many carefully selected illustrations and instructive schematic representations make the chapters easily readable.

Perspectives in Nucleoside and Nucleic Acid Chemistry

Perspectives in Nucleoside and Nucleic Acid Chemistry
Author: Volkan Kisakürek,M. Volkan Kisakürek
Publsiher: John Wiley & Sons
Total Pages: 440
Release: 2000
ISBN: 9783906390215
Category: Science
Language: EN, FR, DE, ES & NL

Perspectives in Nucleoside and Nucleic Acid Chemistry Book Excerpt:

The chemistry of nucleosides and nucleic acids is a rapidly developing field. Many of the most important recent advances in medicinal chemistry have occured in this field with the development of novel nucleoside– and nucleotide–based antiviral and antitumor drugs. New synthesis strategies involving novel protecting groups have helped spur progress in drug–development and genome–sequencing research. This volume, comprised of contributions written by internationally recognized experts, covers cutting–edge developments in current nucleoside and nucleic acid research. The most recent synthesis innovations, including combinatorial approaches, spectroscopy and structural studies, thermodynamic and computational investigations, stability assessments, and medicinal applications are presented. Synthetic, physical, organic, bioorganic, and medicinal chemists working on all aspects of nucleoside and nucleic acid research will value this comprehensive state–of–the–art overview.

Revue roumaine de biochimie

Revue roumaine de biochimie
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1983
ISBN: 1928374650XXX
Category: Biochemistry
Language: EN, FR, DE, ES & NL

Revue roumaine de biochimie Book Excerpt:

RNA Purification and Analysis

RNA Purification and Analysis
Author: Douglas T. Gjerde,Lee Hoang,David Hornby
Publsiher: John Wiley & Sons
Total Pages: 206
Release: 2009-07-10
ISBN: 3527627200
Category: Science
Language: EN, FR, DE, ES & NL

RNA Purification and Analysis Book Excerpt:

This first book on the market covers the many new and important RNA species discovered over the past five years, explaining current methods for the enrichment, separation and purification of these novel RNAs. Building up from general principles of RNA biochemistry and biophysics, this book addresses the practical aspects relevant to the laboratory researcher throughout, while discussing the performance and potential problems of the methods discussed. An appendix contains a glossary with the important terms and techniques used in RNA analysis. By explaining the basic and working principles of the methods, the book allows biochemists and molecular biologists to gain much more expertise than by simply repeating a pre-formulated protocol, enabling them to select the procedure and materials best suited to the RNA analysis task at hand. As a result, they will be able to develop new protocols where needed and optimize and fine-tune the general purpose standard protocols that come with the purification equipment and instrumentation.

DNA Protein Interactions

DNA Protein Interactions
Author: G. Geoff Kneale
Publsiher: Springer Science & Business Media
Total Pages: 428
Release: 2008-02-02
ISBN: 1592595170
Category: Science
Language: EN, FR, DE, ES & NL

DNA Protein Interactions Book Excerpt:

The study of protein-nucleic acid interactions is currently one of the most rapidly growing areas of molecular biology. DNA binding proteins are at the very heart of the regulation and control of gene expression, replication, and recombination: Enzymes that recognize and either modify or cleave specific DNA sequences are equally important to the cell. Some of the techniques reported in this volume can be used to identify previously unknown DNA binding proteins from crude cell extracts. Virtually all are capable of giving direct information on the molecular basis of the interaction—the location of the DNA binding site; the strength and specificity of binding; the identities of individual groups on specific bases involved in binding; the specific amino acid residues of the protein that interact with the DNA; or the effects of protein binding on gross conformation and local structure of DNA. The recognition of DNA sequences by proteins is a complex phenomenon, involving specific hydrogen bonding contacts to the DNA bases ("direct readout") and/or interactions with the sugar-phos phate backbone ("indirect readout"). The latter interactions can also be highly specific because of sequence-dependent conformational changes in the DNA. In addition, intercalation of planar aromatic amino acid side-chains between the DNA bases can occur, most notably with single-stranded DNA binding proteins. Furthermore, when bound, many DNA binding proteins induce drastic structural changes in the DNA as an integral part of their function.