Drug Discovery for Psychiatric Disorders

Drug Discovery for Psychiatric Disorders
Author: Zoran Rankovic,Richard Hargreaves,Matilda Bingham
Publsiher: Royal Society of Chemistry
Total Pages: 678
Release: 2012-10-08
ISBN: 1849734941
Category: Science
Language: EN, FR, DE, ES & NL

Drug Discovery for Psychiatric Disorders Book Excerpt:

The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment of psychiatric patients and even our social perception of mental illnesses cannot be underestimated. However, there is still an urgent medical need for even more effective, safe and well-tolerated treatments. For example, currently available treatments for schizophrenia address mainly the positive symptoms and largely neglect the negative symptoms and cognitive disfunction which greatly impact overall morbidity. Similarly, whilst the current first line antidepressants show significantly improved side effect profiles compared to the first generation therapies, there still up to 40% of patients who are treatment resistant, and even in the patient population which responds well, the onset of action is slow at typically 2-3 weeks. The aim of this book is to provide the first point of call for those involved or just interested in this rapidly expanding and increasingly fragmented field of research and drug discovery. The editors will combine their wide ranging experience and extensive network of contacts with leading scientists and opinion leaders in this field to provide an authoritative reference text covering the evolution, major advances, challenges and future directions in drug discovery and medicinal chemistry for major psychiatric disorders, such as schizophrenia, depression, anxiety, ADHD, bipolar disorder, addiction and autism.

Psychiatric Drug Discovery and Development

Psychiatric Drug Discovery and Development
Author: Strategic Research Institute
Publsiher: Unknown
Total Pages: 135
Release: 2003
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Psychiatric Drug Discovery and Development Book Excerpt:

Drug Discovery for Psychiatric Disorders

Drug Discovery for Psychiatric Disorders
Author: Zoran Rankovic,Richard Hargreaves,Matilda Bingham
Publsiher: Royal Society of Chemistry
Total Pages: 590
Release: 2012
ISBN: 1849733651
Category: Science
Language: EN, FR, DE, ES & NL

Drug Discovery for Psychiatric Disorders Book Excerpt:

This is a wide scope and in-depth coverage of the state of the art and future directions in drug discovery for major psychiatric disorders.

Animal and Translational Models for CNS Drug Discovery Psychiatric Disorders

Animal and Translational Models for CNS Drug Discovery  Psychiatric Disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Academic Press
Total Pages: 528
Release: 2008-11-17
ISBN: 008092039X
Category: Medical
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Psychiatric Disorders Book Excerpt:

Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Psychiatric Disorders is available for purchase individually.

Modern CNS Drug Discovery

Modern CNS Drug Discovery
Author: Rudy Schreiber
Publsiher: Springer Nature
Total Pages: 283
Release: 2021-06-17
ISBN: 3030623513
Category: Medical
Language: EN, FR, DE, ES & NL

Modern CNS Drug Discovery Book Excerpt:

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

Drug Discovery for Schizophrenia

Drug Discovery for Schizophrenia
Author: Tatiana V. Lipina,John C. Roder
Publsiher: Royal Society of Chemistry
Total Pages: 289
Release: 2015-05-13
ISBN: 1782620265
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Discovery for Schizophrenia Book Excerpt:

Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a change in the way schizophrenia is treated by moving away from focusing only on treating symptoms in patients. Innovative drugs emerge from deeper comprehension of the pathological processes that emerge earlier in life, hence, providing strategies for preventative therapy to alter the course of this mental disorder. Amongst other current topics, the book covers new findings in genetics and epigenetics, progress in animal models for schizophrenia and the usage of induced pluripotent stem cells. The combination of these important areas benefit psychiatric neuroscience, filling the gaps in the knowledge of neurobiology of schizophrenia and providing novel perspectives for future drug development.

Phenotypic Drug Discovery

Phenotypic Drug Discovery
Author: Beverley Isherwood,Angelique Augustin
Publsiher: Royal Society of Chemistry
Total Pages: 272
Release: 2020-12-10
ISBN: 1839160799
Category: Medical
Language: EN, FR, DE, ES & NL

Phenotypic Drug Discovery Book Excerpt:

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery
Author: Jens-Uwe Peters
Publsiher: John Wiley & Sons
Total Pages: 510
Release: 2012-03-13
ISBN: 0470590904
Category: Medical
Language: EN, FR, DE, ES & NL

Polypharmacology in Drug Discovery Book Excerpt:

"Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology"--Provided by publisher.

Drug Discovery and Development

Drug Discovery and Development
Author: Izet Kapetanović
Publsiher: BoD – Books on Demand
Total Pages: 542
Release: 2011-12-16
ISBN: 9533076151
Category: Medical
Language: EN, FR, DE, ES & NL

Drug Discovery and Development Book Excerpt:

Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.

Clinical Pharmacology in Psychiatry

Clinical Pharmacology in Psychiatry
Author: Lars F. Gram,Luc P. Balant,Herbert Y. Meltzer,Svein G. Dahl
Publsiher: Springer Science & Business Media
Total Pages: 268
Release: 2013-03-07
ISBN: 3642780105
Category: Medical
Language: EN, FR, DE, ES & NL

Clinical Pharmacology in Psychiatry Book Excerpt:

This book contains the papers from invited lecturers as well as selected contributions presented at the 6th International Meeting on Clinical Pharmacology in Psychiatry (I.M.C.P.P.) held in Geneva, Switzerland, 5-7 June 1991. At this meeting the basic theme of the previous meetings in this series (Chicago 1979, Troms0 1980, Odense 1982, Bethesda 1985, Troms0 1988) was continued, namely, to bridge the gap between experimental development and clinical reality in psychopharmacology. After more than 25 years of intensive research in biological psychiatry, basic understanding of the biological mechanisms underlying major psychiatric diseases has advanced significantly but is still far from complete. Likewise, the hypotheses underlying the development of new psychotropics have been refined and produced a wide spectrum of novel, yet designed compounds. The crucial condition for all progress in this field is reliable, informative clinical testing of new compounds. It is our hope that this book, as a continuation of the earlier publications in this series, provides further evidence of the ongoing interaction between preclinical and clinical scientists, who only together can assure progress in this exciting area of research and clinical practice.

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development
Author: George G. Nomikos,Douglas E. Feltner
Publsiher: Academic Press
Total Pages: 458
Release: 2019-06-18
ISBN: 0128031646
Category: Medical
Language: EN, FR, DE, ES & NL

Translational Medicine in CNS Drug Development Book Excerpt:

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Frontiers in Anti Cancer Drug Discovery

Frontiers in Anti Cancer Drug Discovery
Author: Atta-ur-Rahman,M. Iqbal Choudhary
Publsiher: Bentham Science Publishers
Total Pages: 340
Release: 2018-12-06
ISBN: 1681087014
Category: Medical
Language: EN, FR, DE, ES & NL

Frontiers in Anti Cancer Drug Discovery Book Excerpt:

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The ninth volume of the series features chapters covering the following topics: - New research on the therapeutic intervention of cancer and cancer drug delivery - Dabrafenib usage in melanoma therapy - Targeting autophagy in cancer therapy - Pro-apoptotic and anti-telomerase activity of naturally occurring compounds - CDK inhibitors - Oral nanostructure drug delivery for anti-cancer treatment

Frontiers in CNS Drug Discovery

Frontiers in CNS Drug Discovery
Author: Atta-ur Rahman,M. Iqbal Choudhary
Publsiher: Bentham Science Publishers
Total Pages: 653
Release: 2011-08-12
ISBN: 1608051595
Category: Medical
Language: EN, FR, DE, ES & NL

Frontiers in CNS Drug Discovery Book Excerpt:

"Frontiers in CNS Drug Discovery" is an Ebook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists write contributions on all areas of rational drug design an

Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders

Animal and Translational Models for CNS Drug Discovery  Reward Deficit Disorders
Author: Robert A. McArthur,Franco Borsini
Publsiher: Academic Press
Total Pages: 432
Release: 2009-02-24
ISBN: 0080920403
Category: Medical
Language: EN, FR, DE, ES & NL

Animal and Translational Models for CNS Drug Discovery Reward Deficit Disorders Book Excerpt:

Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.

Handbook of Psychiatric Drugs

Handbook of Psychiatric Drugs
Author: Jeffrey A. Lieberman,Allan Tasman
Publsiher: John Wiley & Sons
Total Pages: 264
Release: 2006-05-16
ISBN: 0470028211
Category: Medical
Language: EN, FR, DE, ES & NL

Handbook of Psychiatric Drugs Book Excerpt:

The Handbook of Psychiatric Drugs is a comprehensive, clear, concise and quick reference to psychiatric drug therapies, designed to guide the clinician on the selection and implementation of treatment for mental illness. Each chapter is organised by drug class and follows a standard format for ease of use. Concise sections on pharmacology and indications for use are followed by detailed information on drug selection, initiation and maintenance of treatment and withdrawal. Adverse effects, contraindications and drug interactions are also reviewed in detail, along with issues such as treatment resistance and treatment evaluation. A handy pocket–sized drug reference, the Handbook of Psychiatric Drugs makes it easy to keep up–to–date with new developments. It is an invaluable resource for all clinicians who use psychiatric drugs to treat medical and psychiatric illness, and an informative read for all those with an interest in the subject.

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery
Author: Jens-Uwe Peters
Publsiher: John Wiley & Sons
Total Pages: 536
Release: 2012-01-20
ISBN: 1118098137
Category: Medical
Language: EN, FR, DE, ES & NL

Polypharmacology in Drug Discovery Book Excerpt:

An essential outline of the main facets of polypharmacology indrug discovery research Extending drug discovery opportunities beyond the "one drug, onetarget" philosophy, a polypharmacological approach to the treatmentof complex diseases is emerging as a hot topic in both industry andacademic research. Polypharmacology in Drug Discovery presents anoverview of the various facets of polypharmacology and how it canbe applied as an innovative concept for developing medicines fortreating bacterial infections, epilepsy, cancer, psychiatricdisorders, and more. Filled with a collection of instructive casestudies that reinforce the material and illuminate the subject,this practical guide: Covers the two-sided nature of polypharmacology—itscontribution to adverse drug reactions and its benefit in certaintherapeutic drug classes Addresses the important topic of polypharmacology in drugdiscovery, a subject that has not been thoroughly covered outsideof scattered journal articles Overviews state-of-the-art approaches and developments to helpreaders understand concepts and issues related topolypharmacology Fosters interdisciplinary drug discovery research by embracingcomputational, synthetic, in vitro and in vivo pharmacological andclinical aspects of polypharmacology A clear road map for helping readers successfully navigatearound the problems involved with promiscuous ligands and targets,Polypharmacology in Drug Discovery provides real examples, in-depthexplanations and discussions, and detailed reviews and opinions tospark inspiration for new drug discovery projects.

Essential CNS Drug Development

Essential CNS Drug Development
Author: Amir Kalali
Publsiher: Cambridge University Press
Total Pages: 215
Release: 2012-06-07
ISBN: 0521766060
Category: Medical
Language: EN, FR, DE, ES & NL

Essential CNS Drug Development Book Excerpt:

Presents the complicated process of CNS drug development in a way that is engaging and informative for professionals and students.

Predictive Approaches in Drug Discovery and Development

Predictive Approaches in Drug Discovery and Development
Author: J. Andrew Williams,Richard Lalonde,Jeffrey R. Koup,David D. Christ
Publsiher: John Wiley & Sons
Total Pages: 408
Release: 2012-02-14
ISBN: 1118230264
Category: Medical
Language: EN, FR, DE, ES & NL

Predictive Approaches in Drug Discovery and Development Book Excerpt:

Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.

Functional Informatics in Drug Discovery

Functional Informatics in Drug Discovery
Author: Sergey Ilyin
Publsiher: CRC Press
Total Pages: 160
Release: 2007-08-27
ISBN: 9781420015683
Category: Medical
Language: EN, FR, DE, ES & NL

Functional Informatics in Drug Discovery Book Excerpt:

Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry. One of the first books to explore this area, Functional Informatics in Drug Discovery examines all aspects of technology integration and information flow in a biopharmaceutical

G Protein Coupled Receptors in Drug Discovery

G Protein Coupled Receptors in Drug Discovery
Author: Kenneth H. Lundstrom,Mark L. Chiu
Publsiher: CRC Press
Total Pages: 376
Release: 2005-07-11
ISBN: 1420028219
Category: Medical
Language: EN, FR, DE, ES & NL

G Protein Coupled Receptors in Drug Discovery Book Excerpt:

The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs