Reactive Oxygen Species ROS Nanoparticles and Endoplasmic Reticulum ER Stress Induced Cell Death Mechanisms

Reactive Oxygen Species  ROS   Nanoparticles  and Endoplasmic Reticulum  ER  Stress Induced Cell Death Mechanisms
Author: Loutfy H. Madkour
Publsiher: Academic Press
Total Pages: 780
Release: 2020-06-27
ISBN: 0128224967
Category: Medical
Language: EN, FR, DE, ES & NL

Reactive Oxygen Species ROS Nanoparticles and Endoplasmic Reticulum ER Stress Induced Cell Death Mechanisms Book Excerpt:

Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment

Nanoparticle Based Drug Delivery in Cancer Treatment

Nanoparticle Based Drug Delivery in Cancer Treatment
Author: Loutfy H. Madkour
Publsiher: CRC Press
Total Pages: 558
Release: 2022-03-03
ISBN: 100053216X
Category: Science
Language: EN, FR, DE, ES & NL

Nanoparticle Based Drug Delivery in Cancer Treatment Book Excerpt:

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

RNA Delivery Function for Anticancer Therapeutics

RNA Delivery Function for Anticancer Therapeutics
Author: Loutfy H. Madkour
Publsiher: CRC Press
Total Pages: 424
Release: 2022-01-26
ISBN: 1000532240
Category: Science
Language: EN, FR, DE, ES & NL

RNA Delivery Function for Anticancer Therapeutics Book Excerpt:

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.

Nanotoxicology and Nanosafety 2 0

Nanotoxicology and Nanosafety 2 0
Author: Ying-Jan Wang
Publsiher: MDPI
Total Pages: 320
Release: 2020-12-29
ISBN: 303936748X
Category: Science
Language: EN, FR, DE, ES & NL

Nanotoxicology and Nanosafety 2 0 Book Excerpt:

With the rapid development of nanotechnology, nanomaterials have been widely applied in many industrial sectors, including medicine, consumer products, and electronics. While such technology has brought benefits and convenience to our daily lives, it may also potentially threaten human health. In some cases, nanomaterials present unexpected risks to both humans and the environment. Assessments of the potential hazards associated with nanotechnology have been emerging, but substantial challenges remain, because the large number of different nanomaterials cannot be effectively evaluated in a timely manner. The development of a good strategy for a nanomaterials hazard assessment not only promotes the more widespread adoption of non-rodent or 3Rs principles, but also makes nanotoxicology testing more ethical, relevant, and cost- and time-efficient. A thorough understanding of the mechanisms by which nanomaterials perturb biological systems is critical for a more comprehensive elucidation of their nanotoxicity, and this will also facilitate the development of prevention and intervention policies against adverse outcomes induced by them. We hope that the articles included in this eBook can provide updated knowledge on nanotoxicology and nanosafety, from the point of view of both toxicology and ecotoxicology.

Toxicity Mechanisms Exposure Toxicokinetic and Risk Assessment Aspects of Metals Toxic for Animals and Humans

Toxicity Mechanisms  Exposure  Toxicokinetic and Risk Assessment Aspects of Metals  Toxic for Animals and Humans
Author: Yanzhu Zhu,Fatma Mohamady El-Demerdash,Xinwei Li,Michel Mansur Machado,Alex Boye
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-03-10
ISBN: 2889746402
Category: Science
Language: EN, FR, DE, ES & NL

Toxicity Mechanisms Exposure Toxicokinetic and Risk Assessment Aspects of Metals Toxic for Animals and Humans Book Excerpt:

Interaction of Nanomaterials with the Immune System

Interaction of Nanomaterials with the Immune System
Author: James C. Bonner,Jared M. Brown
Publsiher: Springer Nature
Total Pages: 223
Release: 2020-01-30
ISBN: 3030339629
Category: Medical
Language: EN, FR, DE, ES & NL

Interaction of Nanomaterials with the Immune System Book Excerpt:

This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.

Biomedical Applications of Nanoparticles

Biomedical Applications of Nanoparticles
Author: Nadine Millot
Publsiher: MDPI
Total Pages: 366
Release: 2020-05-29
ISBN: 3039285424
Category: Medical
Language: EN, FR, DE, ES & NL

Biomedical Applications of Nanoparticles Book Excerpt:

This book provides an overview of the design and physico-chemical properties of nanoparticles developed for biomedical applications such as targeting and detection of pathologies, nanovectorization of drugs, radiosensitization, metal detection, and nanocomposite implants. The considerations necessary when developing a new nanomedicine are also developed, including toxicological investigation, biodistribution, and efficacy. This book provides an accurate and current representation of the field by addressing the promises and hurdles of nanomedicine via 20 different pertinent studies. Covering a wide range of areas, this book is an excellent partner for physico-chemists, doctors, pharmacologists, and biochemists working on nanosciences dedicated to medicine, both in industry and in academia.

Drug Delivery Technology Development in Canada

Drug Delivery Technology Development in Canada
Author: Kishor M.Wasan,Ildiko Badea
Publsiher: MDPI
Total Pages: 352
Release: 2019-12-19
ISBN: 303928004X
Category: Science
Language: EN, FR, DE, ES & NL

Drug Delivery Technology Development in Canada Book Excerpt:

Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Over the past 30 years, numerous Canadian-based biotechnology companies have been formed from the inventions conceived and developed within academic institutions that have led to the development of important drug delivery products that have enhanced the landscape of drug therapy in the treatment of cancer to infectious diseases. This Special Issue serves to highlight and capture the contemporary progress of drug delivery within the prevailing Canadian context. We invite articles on all aspects of drug delivery sciences from pre-clinical formulation development to human clinical trials that bring to light the world-class research currently undertaken in Canada for this Special Issue.

Protein Kinase mediated Decisions Between Life and Death

Protein Kinase mediated Decisions Between Life and Death
Author: Ayse Basak Engin,Atilla Engin
Publsiher: Springer Nature
Total Pages: 415
Release: 2021-02-04
ISBN: 3030498441
Category: Medical
Language: EN, FR, DE, ES & NL

Protein Kinase mediated Decisions Between Life and Death Book Excerpt:

Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Action Mechanisms of Traditional Medicinal Plants used to Control Type 2 Diabetes or Conditions of Metabolic Syndrome

Action Mechanisms of Traditional Medicinal Plants used to Control Type 2 Diabetes or Conditions of Metabolic Syndrome
Author: Mohamed Eddouks,Adolfo Andrade-Cetto,Michael Heinrich,Vincenzo De Feo,William C. Cho
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-02-09
ISBN: 2889664694
Category: Science
Language: EN, FR, DE, ES & NL

Action Mechanisms of Traditional Medicinal Plants used to Control Type 2 Diabetes or Conditions of Metabolic Syndrome Book Excerpt:

Nanotechnology and Plant Sciences

Nanotechnology and Plant Sciences
Author: Manzer H. Siddiqui,Mohamed H. Al-Whaibi,Firoz Mohammad
Publsiher: Springer
Total Pages: 303
Release: 2015-01-27
ISBN: 3319145029
Category: Science
Language: EN, FR, DE, ES & NL

Nanotechnology and Plant Sciences Book Excerpt:

This book presents a holistic view of the complex and dynamic responses of plants to nanoparticles, the signal transduction mechanisms involved, and the regulation of gene expression. Further, it addresses the phytosynthesis of nanoparticles, the role of nanoparticles in the antioxidant systems of plants and agriculture, the beneficial and harmful effects of nanoparticles on plants, and the application of nanoparticles and nanotubes to mass spectrometry, aiming ultimately at an analysis of the metabolomics of plants. The growing numbers of inventions in the field of nanotechnology are producing novel applications in the fields of biotechnology and agriculture. Nanoparticles have received much attention because of the unique physico-chemical properties of these compounds. In the life sciences, nanoparticles are used as “smart” delivery systems, prompting the Nobel Prize winner P. Ehrlich to refer to these compounds as “magic bullets.” Nanoparticles also play an important role in agriculture as compound fertilizers and nano-pesticides, acting as chemical delivery agents that target molecules to specific cellular organelles in plants. The influence of nanoparticles on plant growth and development, however, remains to be investigated. Lastly, this book reveals the research gaps that must be bridged in the years to come in order to achieve larger goals concerning the applications of nanotechnology in the plants sciences. In the 21st century, nanotechnology has become a rapidly emerging branch of science. In the world of physical sciences, nanotechnological tools have been exploited for a broad range of applications. In recent years, nanoparticles have also proven useful in several branches of the life sciences. In particular, nanotechnology has been employed in drug delivery and related applications in medicine.