Rearrangements with Migration to Electrophilic Heteroatomic Centers

Rearrangements with Migration to Electrophilic Heteroatomic Centers
Author: Sosale Chandrasekhar
Publsiher: Elsevier
Total Pages: 300
Release: 2022-01-15
ISBN: 9780128237434
Category: Science
Language: EN, FR, DE, ES & NL

Rearrangements with Migration to Electrophilic Heteroatomic Centers Book Excerpt:

Rearrangements with Migration to Electrophilic Heteroatomic Centers: Timeless Classics in Organic Synthesis covers the basic principles and synthetic applications of a critically important class of organic reactions that date back to the founding period of organic chemistry. These reactions are not only of historical and pedagogical interest, but also have great practical value to this day, being inevitable in any strategy concerning the introduction of nitrogen and oxygen functionality. The book is made up of three parts, dealing with the Beckmann reaction, the Hoffmann family of reactions and the Baeyer-Villiger reaction. Each part begins with a brief historical introduction followed by a mechanistic discussion. The synthetic applications are then discussed in detail, focusing on current developments and improvements. The book strikes a balance between delineation and exhaustiveness, with up-to-date refences for readers requiring in-depth coverage. Relevant industrial applications, including pharmaceutical processes, are included. This reference will be a key resource for organic synthesis researchers and students, working in academia and industry. Summarizes mechanistic background with an emphasis on synthetic applications Up to date references allow for locating original papers for experimental procedures Applications in the synthesis of complex molecules and natural products are included to judge the scope and limitations of each reaction

Modern Physical Organic Chemistry

Modern Physical Organic Chemistry
Author: Eric V. Anslyn,Dennis A. Dougherty
Publsiher: University Science Books
Total Pages: 1148
Release: 2006
ISBN: 9781891389313
Category: Science
Language: EN, FR, DE, ES & NL

Modern Physical Organic Chemistry Book Excerpt:

In additionto covering thoroughly the core areas of physical organic chemistry -structure and mechanism - this book will escort the practitioner of organic chemistry into a field that has been thoroughlyupdated.

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry
Author: Anonim
Publsiher: Elsevier
Total Pages: 323
Release: 2000-07-04
ISBN: 0080493564
Category: Science
Language: EN, FR, DE, ES & NL

Advances in Heterocyclic Chemistry Book Excerpt:

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area--one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties.

Organic Reactions Volume 102

Organic Reactions  Volume 102
Author: Anonim
Publsiher: John Wiley & Sons
Total Pages: 990
Release: 2020-07-08
ISBN: 1119651220
Category: Science
Language: EN, FR, DE, ES & NL

Organic Reactions Volume 102 Book Excerpt:

The 102nd volume in this series for organic chemists in academia and industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author: Shazia Anjum,Elena Soriano,José Luis Marco-Contelles
Publsiher: Elsevier Inc. Chapters
Total Pages: 538
Release: 2013-06-25
ISBN: 0128084685
Category: Science
Language: EN, FR, DE, ES & NL

Studies in Natural Products Chemistry Book Excerpt:

Molecular rearrangements occupy center stage in the development of organic synthesis and, consequently, in the impressive achievements that have resulted in the total synthesis of many complex natural products in the last decades. The purpose of this chapter, in this volume of a book series dedicated to the Studies in Natural Product Chemistry, is to show a set of selected and organized molecular rearrangements based on a personal choice of expertise related to the synthesis of complex bioactive molecules. Our selection addresses [3,3]-sigmatropic rearrangements, which continue to provide excellent opportunities for reaching high chemical diversity, operating in efficient synthetic schemes. [3,3]-Sigmatropic rearrangements, such as the Cope and Claisen rearrangements, are among the most basic and useful transformations in synthetic organic chemistry. This is possibly due to the fact that these rearrangements are efficient methods for the synthesis of quaternary, sterically hindered chiral centers, and for the stereoselective formation of carbon–carbon and carbon–heteroatom bonds. In addition, [3,3]-sigmatropic rearrangements can be easily integrated in, and adapted to, cascade processes as a simple method to prepare complex molecules in atom-efficient reactions. Consequently, in the context of [3,3]-sigmatropic rearrangements, we focus on the transformations of propargylic esters, whose rearrangements, in different experimental conditions, have been largely exploited for the synthesis of interesting key and useful intermediates. The rearrangements can be promoted by protic acids, Lewis acids, and noble metals such as Pt, Au, or Cu salts, or complexes that have recently emerged as the most popular and potent electrophilic activators of alkynes toward a number of nucleophilic agents, under homogeneous conditions.

Silver Catalysis in Organic Synthesis 2 Volume Set

Silver Catalysis in Organic Synthesis  2 Volume Set
Author: Chao-Jun Li,Xihe Bi
Publsiher: John Wiley & Sons
Total Pages: 848
Release: 2019-04-29
ISBN: 3527342818
Category: Science
Language: EN, FR, DE, ES & NL

Silver Catalysis in Organic Synthesis 2 Volume Set Book Excerpt:

Covers all the aspects of the recent achievements in silver catalyzed reactions Silver catalysis has emerged as a powerful tool in the field of organic synthesis. This comprehensive book systematically explores the unique performance of silver catalysis, introducing all the recent progress of silver catalysis in organic synthesis. It clearly emphasizes the unique features of silver catalysis and provides the reaction mechanism involved. This two-volume book also provides vivid schematics and tables throughout to enhance the accessibility to the relevant theory and mechanisms. Silver Catalysis in Organic Synthesis begins with an introduction to Silver Chemistry before moving on to chapters covering: Silver-Catalyzed Cycloaddition Reactions; Silver-Catalyzed Cyclizations; Silver-Mediated Radical Reactions; Silver-Mediated Fluorination, Perfluoroalkylation and Trifluoromethylthiolation Reactions; Coupling Reactions and C-H Functionalization; Silver-Catalyzed CO2 Incorporation; Silver-Catalyzed Carbene, Nitrene, and Silylene Transfer Reactions; Asymmetric Silver-Catalyzed Reactions; Silver-Catalyzed Reduction and Oxidation of Aldehydes and Their Derivatives; Silver Complexes in Organic Transformations; and Silver Nanoparticles in Organic Transformations. -Covers recently developed organic reactions catalyzed by silver, along with their reaction mechanism -Introduces many new reactions and mechanisms related to silver catalysis -Offers professionals and newcomers in the related fields a survey of new advances in silver catalysis in organic synthesis Silver Catalysis in Organic Synthesis will appeal to a wide readership including chemists, biochemists, pharmaceutical scientists, biomedical researchers, agriculture scientists, and graduate students in the related fields.

Advanced Organic Chemistry

Advanced Organic Chemistry
Author: Bernard Miller
Publsiher: Unknown
Total Pages: 338
Release: 1998
ISBN: 1928374650XXX
Category: Chemistry, Organic
Language: EN, FR, DE, ES & NL

Advanced Organic Chemistry Book Excerpt:

This text covers the principles of mechanisms of organic reactions in a qualitative way and features a chapter on heterocyclic chemistry. End of chapter exercises feature references to current literature

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Author: Anonim
Publsiher: Newnes
Total Pages: 538
Release: 2013-06-25
ISBN: 0444626328
Category: Science
Language: EN, FR, DE, ES & NL

Studies in Natural Products Chemistry Book Excerpt:

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable resource for natural products and medicinal chemistry

Dynamic Stereochemistry of Chiral Compounds

Dynamic Stereochemistry of Chiral Compounds
Author: Christian Wolf
Publsiher: Royal Society of Chemistry
Total Pages: 534
Release: 2008
ISBN: 0854042466
Category: Science
Language: EN, FR, DE, ES & NL

Dynamic Stereochemistry of Chiral Compounds Book Excerpt:

A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.

Target Organ Toxicity

Target Organ Toxicity
Author: Cohen
Publsiher: CRC Press
Total Pages: 246
Release: 1986-08-31
ISBN: 9780849357756
Category: Medical
Language: EN, FR, DE, ES & NL

Target Organ Toxicity Book Excerpt:

This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Target Organ Toxicity

Target Organ Toxicity
Author: Gerald M. Cohen
Publsiher: CRC Press
Total Pages: 230
Release: 2019-07-17
ISBN: 1000694194
Category: Medical
Language: EN, FR, DE, ES & NL

Target Organ Toxicity Book Excerpt:

First published in 1986: The purpose of these volumes is to provide a valuable reference for established investigators and postgraduate students in toxicology.

Target Organ Toxicity Volume I

Target Organ Toxicity  Volume I
Author: Gerald M. Cohen
Publsiher: CRC Press
Total Pages: 242
Release: 2020-01-29
ISBN: 1000714543
Category: Medical
Language: EN, FR, DE, ES & NL

Target Organ Toxicity Volume I Book Excerpt:

This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Organometallic Chemistry of the Transition Elements

Organometallic Chemistry of the Transition Elements
Author: Florian P. Pruchnik
Publsiher: Springer Science & Business Media
Total Pages: 758
Release: 2013-06-29
ISBN: 1489920765
Category: Science
Language: EN, FR, DE, ES & NL

Organometallic Chemistry of the Transition Elements Book Excerpt:

Organometallic chemistry belongs to the most rapidly developing area of chemistry today. This is due to the fact that research dealing with the structure of compounds and chemical bonding has been greatly intensified in recent years. Additionally, organometallic compounds have been widely utilized in catalysis, organic synthesis, electronics, etc. This book is based on my lectures concerning basic organometallic chemistry for fourth and fifth year chemistry students and on my lectures concerning advanced organometallic chemistry and homogeneous catalysis for Ph.D. graduate students. Many recent developments in the area of organometallic chemistry as weIl as homogeneous catalysis are presented. Essential research results dealing with a given class of organometallic compounds are discussed briefly. Results of physicochemical research methods of various organometallic compounds as weIl as their synthesis, properties, structures, reactivities, and applications are discussed more thoroughly. The selection of tabulated data is arbitrary because, often, it has been impossible to avoid omissions. Nevertheless, these data can be very helpful in understanding properties of organometaIlic compounds and their reactivities. All physical data are given in SI units; the interatomic distances are given in pm units in figures and tables. I am indebted to Professor S. A. Duraj for translating and editing this book. His remarks, discussions, and suggestions are greatly appreciated. I also express gratitude to Virginia E. Duraj for editing and proofreading.

International Symposium on Bioorganic Chemistry

International Symposium on Bioorganic Chemistry
Author: International Symposium on Bioorganic Chemistry
Publsiher: Unknown
Total Pages: 325
Release: 1986
ISBN: 9780897663373
Category: Science
Language: EN, FR, DE, ES & NL

International Symposium on Bioorganic Chemistry Book Excerpt:

Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences
Author: Thomas Lincoln Casey,Gilbert Van Ingen,Charles Lane Poor,Edmund Otis Hovey,Ralph Winfred Tower
Publsiher: Unknown
Total Pages: 387
Release: 2003
ISBN: 1928374650XXX
Category: MSH (Hormone)
Language: EN, FR, DE, ES & NL

Annals of the New York Academy of Sciences Book Excerpt:

Gold Catalyzed Cycloisomerization Reactions Through Activation of Alkynes

Gold Catalyzed Cycloisomerization Reactions Through Activation of Alkynes
Author: Antoine Simonneau
Publsiher: Springer
Total Pages: 245
Release: 2014-05-21
ISBN: 3319067079
Category: Science
Language: EN, FR, DE, ES & NL

Gold Catalyzed Cycloisomerization Reactions Through Activation of Alkynes Book Excerpt:

Antoine Simonneau's thesis highlights the development of new cycloisomerization reactions through the activation of alkynes with gold complexes. First Simonneau describes 1,6-enynes and their direct conversion into allenes through 1,5-hydride or ester migration processes. The author and his team used appropriate propargylic functional groups to achieve this conversion. This study shows that O-tethered 1,6-enynes carrying a strained cycloalkane at the propargylic position could undergo a cyclopropanation/ring expansion cascade reaction. The author employed this rearrangement as the starting point in the design of a new macro cycle synthesis. The next part of the thesis focuses on the cycloisomerization of diynes involving as the first step of the process the rearrangement of one alkyne partner into an allene thanks to a gold-catalyzed 1,3-shift of a propargylic ester. The thesis discloses a new cycloisomerization pattern featuring a 1,5-carbonyl transfer, giving rise to unprecedented cross-conjugated diketones. In the final part of the research, Simmoneau investigates the gold-catalyzed cycloisomerization mechanism of 1,6-enynes and questions the intermediacy of gold acetylides. By the means of NMR and mass spectrometry analysis, theoretical treatment and solution experiments, it was possible to rule out the involvement of these species in the catalytic cycle. This thesis has led to a number of publications in high-impact journals.

Summaries of Projects Completed

Summaries of Projects Completed
Author: National Science Foundation (U.S.)
Publsiher: Unknown
Total Pages: 1100
Release: 2022
ISBN: 1928374650XXX
Category: Engineering
Language: EN, FR, DE, ES & NL

Summaries of Projects Completed Book Excerpt:

Organic Synthesis via Organometallics OSM 4

Organic Synthesis via Organometallics  OSM 4
Author: Dieter Enders
Publsiher: Vieweg + Teubner Verlag
Total Pages: 238
Release: 1993
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Organic Synthesis via Organometallics OSM 4 Book Excerpt:

Organometallics playa key role in organic synthesis. Carbon carbon bond formation without main group and transition metal based reagents as well as catalysts is hardly imaginable, and the tremendous success in recent years in the field of stereoselective synthesis of complex biologically active com­ pounds would have been impossible without the advances in organometallic chemistry. From the wealth of carbon carbon bond forming reactions in organotransition metal chemistry many new methods have evolved. This was aided considerably by a deepening of our understanding of the relevant reaction mechanisms. Organometallic chemistry is the bridge par excellence between the traditional fields of inorganic and organiC chemistry. It was the intention of the "Volkswagen-Stiftung" to broaden this bridge by starting in 1986 the new interdisciplinary program "Organic Synthesis via Organo­ metallics". From its very beginning this program grew up after 6 years to now more than 60 projects and its encompasses besides its main topic "Organic Synthesis" mechanistic and structural aspects of organometallic chemistry as well. In a series of symposia sponsored by the "Volkswagen-Stiftung", the former of which were held in Hamburg (February 1986), Wiirzburg (October 1988) and Marburg (July 1990), a forum for intensive discussions and SCientific exchange was established. There, scientists participating in the program met with other experts form academia and from industry. The forth symposium was held in Aachen from July 15 to 18, 1992.

Glycoscience Chemistry and Chemical Biology I III

Glycoscience  Chemistry and Chemical Biology I   III
Author: Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem
Publsiher: Springer Science & Business Media
Total Pages: 2872
Release: 2012-12-06
ISBN: 3642568742
Category: Science
Language: EN, FR, DE, ES & NL

Glycoscience Chemistry and Chemical Biology I III Book Excerpt:

Glycostructures play a highly diverse and crucial role in a myriad of organisms and systems in biology, physiology, medicine, and bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and chemistry behind them. In this set the editors present up-to-date information on glycostructures, their chemistry and chemical biology, in the form of a comprehensive survey. The text is accompanied by over 2000 figures, chemical structures and reaction schemes and more than 9000 references. The accompanying CD-ROM enables, besides text searches, searches for structures, schemes, and other information.

Summaries of Projects Completed in Fiscal Year

Summaries of Projects Completed in Fiscal Year
Author: National Science Foundation (U.S.)
Publsiher: Unknown
Total Pages: 135
Release: 1978
ISBN: 1928374650XXX
Category: Engineering
Language: EN, FR, DE, ES & NL

Summaries of Projects Completed in Fiscal Year Book Excerpt: