Recent Advances in iPSC Disease Modeling Volume 1

Recent Advances in iPSC Disease Modeling  Volume 1
Author: ALEXANDER BIRBRAIR
Publsiher: Academic Press
Total Pages: 320
Release: 2020-07-16
ISBN: 0128232692
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Disease Modeling Volume 1 Book Excerpt:

Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Current Progress in iPSC Disease Modeling

Current Progress in iPSC Disease Modeling
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 324
Release: 2021-11-26
ISBN: 0323856438
Category: Science
Language: EN, FR, DE, ES & NL

Current Progress in iPSC Disease Modeling Book Excerpt:

Current Progress in iPSC Disease Modeling, Volume Fourteen in the Advances in Stem Cell Biology series, is a timely and expansive collection of information and new discoveries in the field. This new volume addresses advances in research on how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions once impossible for some human diseases. This volume addresses iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids, and more. It is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field. Provides an overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers advances in research on how induced pluripotent stem cells are used to create new tissues/organs Contributed by world-renowned experts in the field

Novel Concepts in iPSC Disease Modeling

Novel Concepts in iPSC Disease Modeling
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 336
Release: 2022-01-25
ISBN: 0128238836
Category: Science
Language: EN, FR, DE, ES & NL

Novel Concepts in iPSC Disease Modeling Book Excerpt:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs - Novel Concepts, Volume 15 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson’s disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson’s disease, graft vs. host disease, and much more Contributed by world-renown experts in the field

Recent Advances in iPSC Technology

Recent Advances in iPSC Technology
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 334
Release: 2021-03-31
ISBN: 012822326X
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Technology Book Excerpt:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC Technology, Volume 5 addresses the progress in induced pluripotent stem cells (iPSCs) technologies. Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes different technologies and strategies to use iPSCs for biological and clinical benefit. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-the-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. This volume will cover hot topics in the iPSC field, such as iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the noncoding genome, modeling of blood–brain barrier with iPSCs, mathematical modeling of iPSCs, iPSCs to study human brain evolution, selfrenewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics. Covers the following topics: iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the non-coding genome, modeling of blood-brain barrier with iPSCs, mathematical modelling of iPSCs, iPSCs to study human brain evolution, self-renewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. Contributed by world-renown experts in the field

Recent Advances in iPSC Derived Cell Types

Recent Advances in iPSC Derived Cell Types
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 282
Release: 2021-02-21
ISBN: 0128224541
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances in iPSC Derived Cell Types Book Excerpt:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC-derived Cell Types, Volume 4 addresses how different cell types can be derived from induced pluripotent stem cells. Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to form different cell types which can be used in cell therapy as well as to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cellular populations, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs to derive different cell types, such as: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, ßpancreatic cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine and therapeutics. Covers the following cell types derived from iPSCs: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, ßpancreatic cells, and more. Contributions from stem cell leaders around the world

Medical Applications of iPS Cells

Medical Applications of iPS Cells
Author: Haruhisa Inoue,Yukio Nakamura
Publsiher: Springer
Total Pages: 190
Release: 2019-04-01
ISBN: 9811336725
Category: Medical
Language: EN, FR, DE, ES & NL

Medical Applications of iPS Cells Book Excerpt:

This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

Lung Stem Cells in the Epithelium and Vasculature

Lung Stem Cells in the Epithelium and Vasculature
Author: Amy Firth,Jason X.-J. Yuan
Publsiher: Springer
Total Pages: 345
Release: 2015-05-23
ISBN: 3319162322
Category: Science
Language: EN, FR, DE, ES & NL

Lung Stem Cells in the Epithelium and Vasculature Book Excerpt:

This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed. World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.

iPSCs for Modeling Central Nervous System Disorders Volume 6

iPSCs for Modeling Central Nervous System Disorders  Volume 6
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 352
Release: 2021-04-28
ISBN: 032385642X
Category: Science
Language: EN, FR, DE, ES & NL

iPSCs for Modeling Central Nervous System Disorders Volume 6 Book Excerpt:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders. Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology and its application in neurobiology. Covers the following CNS diseases: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several CNS human diseases.

Recent Advances in iPSCs for Therapy Volume 3

Recent Advances in iPSCs for Therapy  Volume 3
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 368
Release: 2021-02-15
ISBN: 0128222298
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances in iPSCs for Therapy Volume 3 Book Excerpt:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders. The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson's disease, Huntington's disease, ischemic stroke, Alzheimer's disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more. The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. . Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics . Covers the possible use of iPSCs for hair loss disorders, Parkinson's disease, Huntington's disease, ischemic stroke, Alzheimer's disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more . Contributions from stem cell leaders around the world

Recent Advances in Parkinson s Disease

Recent Advances in Parkinson s Disease
Author: Anonim
Publsiher: Academic Press
Total Pages: 574
Release: 2020-04-02
ISBN: 0444642617
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances in Parkinson s Disease Book Excerpt:

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields

Programmed Cells from Basic Neuroscience to Therapy

Programmed Cells from Basic Neuroscience to Therapy
Author: Fred H. Gage,Yves Christen
Publsiher: Springer Science & Business Media
Total Pages: 130
Release: 2013-05-13
ISBN: 3642366481
Category: Medical
Language: EN, FR, DE, ES & NL

Programmed Cells from Basic Neuroscience to Therapy Book Excerpt:

The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases. Among these issues are the variability in PSC generation methods, variability between individuals, epigenetic/genetic instability and the ability to obtain disease-relevant subtypes of neurons . Current protocols for differentiating PSC into specific subtypes of neurons are under development, but more and better protocols are needed. Understanding the molecular pathways involved in human neural differentiation will facilitate the development of methods and tools to enrich and monitor the generation of specific subtypes of neurons that would be more relevant in modeling different neurological diseases.

Recent Advances in Stem Cells

Recent Advances in Stem Cells
Author: Essam M. Abdelalim
Publsiher: Springer
Total Pages: 269
Release: 2016-09-14
ISBN: 3319332708
Category: Medical
Language: EN, FR, DE, ES & NL

Recent Advances in Stem Cells Book Excerpt:

This volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications. The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron diseases, and diabetes as well as their application in cancer; ASCs are discussed in the contexts of banking of umbilical cord stem cells, use of multipotential stromal cells (MSCs) for bone repair, cellular interactions during fracture repair stages, and therapeutic applications of neural crest stem cells and lung stem cells. The text is organized by sections dealing with PSCs and ASCs specifically, presenting the reader with a comprehensive examination of both these forms of stem cells. Expertly authored and drawing from a wealth of international perspectives, Recent Advances in Stem Cells: From Basic Research to Clinical Applications presents a succinct yet detailed review of cutting-edge research in this rapidly expanding field. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is essential reading for academics, researchers, and clinicians in the fields of cell biology, genetics, nephrology, osteology, oncology, and pulmonology.

Mitochondrial OXPHOS System Emerging Concepts and Technologies and Role in Disease

Mitochondrial OXPHOS System  Emerging Concepts and Technologies and Role in Disease
Author: David Pacheu-Grau,Erika Fernandez-Vizarra,Gloria Garrabou,Sylvie Callegari
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-06-06
ISBN: 2889763307
Category: Science
Language: EN, FR, DE, ES & NL

Mitochondrial OXPHOS System Emerging Concepts and Technologies and Role in Disease Book Excerpt:

Recent Advances in iPSCs for Therapy

Recent Advances in iPSCs for Therapy
Author: Alexander Birbrair
Publsiher: Academic Press
Total Pages: 368
Release: 2021-01-30
ISBN: 032385186X
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances in iPSCs for Therapy Book Excerpt:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders. The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more. The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics Covers the possible use of iPSCs for hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more Contributions from stem cell leaders around the world

Brain Organoids Modeling in Neuroscience

Brain Organoids  Modeling in Neuroscience
Author: Cristina Cereda,Alysson Renato Muotri,Anna Maria Di Giulio
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-12-18
ISBN: 2889662640
Category: Science
Language: EN, FR, DE, ES & NL

Brain Organoids Modeling in Neuroscience Book Excerpt:

Stem Cells in Modeling Human Genetic Diseases

Stem Cells in Modeling Human Genetic Diseases
Author: Mayana Zatz,Oswaldo Keith Okamoto
Publsiher: Springer
Total Pages: 147
Release: 2015-08-11
ISBN: 3319183141
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cells in Modeling Human Genetic Diseases Book Excerpt:

While most stem cell books focus on basic aspects and/or cell therapy, this book emphasizes the relevance of stem cells obtained from patients, the so-called “patients in a petri dish” as tools to investigate human genetic diseases for which there are no available effective treatment. Chapters embrace several examples of the use of iPS cell technology, a recent Nobel Prize-winning scientific breakthrough, to obtain patient-specific pluripotent cells from which many types of specialized cells involved in a particular disease can be generated, including psychiatric and neurodegenerative disorders, muscular dystrophies, laminopathies, among others. The text is a current and timely resource for postgraduate students, scientists and clinicians, interested in applications of this rapidly developing field of research in disease modeling, drug development, and emerging issues that it brings to regenerative medicine.

Induced Pluripotent Stem Cell Based Disease Modeling and Drug Discovery Can We Recapitulate Cardiovascular Disease on a Culture Dish

Induced Pluripotent Stem Cell Based Disease Modeling and Drug Discovery  Can We Recapitulate Cardiovascular Disease on a Culture Dish
Author: Jong-Kook Lee,Shinsuke Yuasa,Masayuki Yazawa
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-02-24
ISBN: 2889745058
Category: Science
Language: EN, FR, DE, ES & NL

Induced Pluripotent Stem Cell Based Disease Modeling and Drug Discovery Can We Recapitulate Cardiovascular Disease on a Culture Dish Book Excerpt:

Genome wide Approaches for Understanding Disease Mechanisms in Human IPS Derived Cells

Genome wide Approaches for Understanding Disease Mechanisms in Human IPS Derived Cells
Author: Valerie Sapp
Publsiher: Unknown
Total Pages: 130
Release: 2020
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Genome wide Approaches for Understanding Disease Mechanisms in Human IPS Derived Cells Book Excerpt:

Human iPSCs derived cells provide the context to uncover novel mechanisms of development and disease in patient specific primary cells. The establishment of genome-scale functional genomics based approaches in iPSC derived cells complements recent advances in disease modeling in these cells and is well poised to highlight novel human specific, cell-autonomous mechanisms of disease. In the decade since their discovery, iPSC derived cardiomyocyte models have been developed for a range of conditions from hereditary cardiomyopathies and channelopathies to drug induced cardiotoxicity. The ability to leverage iPSC derived cells to understand disease mechanisms at genome-scale had been limited by a lack of pooled-format functional genomics screening approaches in these cells. In Chapter 2 of this dissertation I outline the optimized methods we developed for CRISPR screening in human iPS derived cells which optimize for infection with a genome-scale CRISPR library and allow screening in functional iPS derived cardiomyocytes with preserved library representation. In Chapter 3 we apply this to uncover novel mechanisms of drug induced cardiotoxicity, which is both a major impediment to new drug approval and a limiting factor in the utilization of approved drugs. We discover the transporter SLCO1A2 as a novel mediator of doxorubicin induced cardiotoxicity in cardiomyocytes, but not breast cancer cells. Through this discovery we highlight the utility of genome-scale functional genomics screening in specifically human differentiated cells of interest. In addition to their utility for modeling human disease, iPS cells have also provided a context to identify novel factors governing pluripotency maintenance and cell fate specification and have provided critical insights into the contribution of transcriptional and signaling pathways in cell fate decisions. Experiments to identify the role of signaling metabolites in cell fate specification have been limited by insufficient techniques to measure and characterize the vast majority of signaling metabolites. Recent advances in untargeted mass-spectrometry afford us the opportunity for to profile thousands of novel signaling lipids in cardiomyocyte specification. We identify a saturated dihydroxy fatty acids as a new family of pluripotency associated metabolites, which have the potential to govern stemness.

Recent Advances in Cardiotoxicity Testing

Recent Advances in Cardiotoxicity Testing
Author: Tamer M. A. Mohamed,Javid Moslehi,Jonathan Satin
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-01-05
ISBN: 2889719545
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances in Cardiotoxicity Testing Book Excerpt:

Recent Advances on Myocardium Physiology

Recent Advances on Myocardium Physiology
Author: Norio Fukuda,Henk Granzier,Shin’Ichi Ishiwata,Sachio Morimoto
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-07-27
ISBN: 2889710866
Category: Science
Language: EN, FR, DE, ES & NL

Recent Advances on Myocardium Physiology Book Excerpt: