Schwann Spectrum

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Languange : en
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Spectrum

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Languange : en
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Schwann Spectrum

Author by : Schwann Publications
Languange : en
Publisher by : Schwann Publications
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Continued Learning Of Tissue Specific Immunity From The Immuno Pathological Spectrum Of Leprosy

Author by : Pranab Kumar Das
Languange : en
Publisher by : Frontiers Media SA
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Description : Leprosy is one of the oldest recorded debilitating diseases affecting mankind, the immunopathology of which is characterized by fluctuating granulomatous inflammation that targets mainly skin and peripheral nerve. The disease is caused by infection with Mycobacterium leprae, a slow growing obligatory intracellular and non-cultivatable organism. The disease is manifested with diverse pathology due to varied immune (both innate and adaptive) responses of the hosts as a result of cognate interaction with the organism. Of note, leprosy can be regarded as a unique model to elucidate the complexity of host immunity at both skin and systemic levels.


The British Union Catalogue Of Music Periodicals

Author by : John Wagstaff
Languange : en
Publisher by : Routledge
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Description : First published in 1998, the aim of this catalogue is to help students, researchers and librarians determine the UK locations of over 2,000 music periodical titles held in public, academic and national libraries. Over 220 libraries in the UK have been surveyed, from St. Austell to Aberdeen, Aberystwyth to Brighton. Each catalogue entry provides detailed information on library holdings, and full bibliographic details of periodical titles, including ISSNs. The main catalogue is preceded by an address list, and by a preface outlining the history of music periodicals in Britain, together with statistical tables.


Fundamentals Of Collection Development Management

Author by : Peggy Johnson
Languange : en
Publisher by : American Library Association
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Description : Taking a fresh approach, this comprehensive guide outlines the step-by-step process of collection development and management. Expert librarian Peggy Johnson offers tips for organizing and staffing, conceiving policy and creating budgets, and developing, marketing and evaluating collections.


Reference Sources For Small And Medium Sized Libraries

Author by : Scott Kennedy
Languange : en
Publisher by : American Library Association
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Total Read : 98
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Description : An annotated bibliography lists reference sources for those academic and public libraries that can't buy everything but want the best for their patrons


Nature

Author by : Sir Norman Lockyer
Languange : en
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How To Work With The Microscope

Author by : Lionel Smith Beale
Languange : en
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The Academy

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American Chemical Journal

Author by : Ira Remsen
Languange : en
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Engineering Optogentically Controlled Schwann Cells

Author by : Tasneem Hassan Muna
Languange : en
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Total Read : 78
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Description : Spinal cord injury (SCI) affects millions of people worldwide. It is a complicated disease with no cure that leaves patients with permanent neurological deficits, mainly because damaged neurons fail to regenerate after SCI. Schwann cells (SC) play important role in supporting axon regeneration after peripheral nerve injury. Their regenerative potential makes them ideal candidates for use in SCI to support axon regeneration. However, a significant improvement in recovery is seen only when SC are combined with additional therapeutic agents. Administration of such agents often requires multiple injections, which increases chances of inflammation, infection and complicates dosage control. Engineered SC that produce therapeutic agents at the site of SCI can obviate the need for multiple injections. What is currently lacking is an approach that allows to control engineered SC post-transplantation. The objective of this project was to test an optogenetic approach to controlling gene expression in SC. Light in the near-infrared window (NIRW) encompasses the spectrum of 670 to 900 nm. NIRW light penetrates deeply through mammalian tissues and is safe for medical applications. NIRW light represents a non-invasive way of achieving spatio-temporal control over transplanted cells. In this study, we engineered SC stably expressing a NIRW light-responsive adenylyl cyclase, IlaM5. We showed that NIRW irradiation activates expression of a reporter luciferase from a cAMP-dependent promoter. Several fold increase in luciferase levels were observed following a one-hour long irradiation of SC. The activation levels were higher if biliverdin, the chromophore for IlaM5, was added to SC exogenously. This study represents a proof-of-concept that SC can be effectively engineered to respond to NIRW light, which opens opportunities for translational applications of engineered, NIRW light-controlled SC in spinal cord regeneration.


Report Of The Annual Meeting

Author by : British Association for the Advancement of Science. Meeting
Languange : en
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Total Read : 91
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Fifty Years Of Science

Author by : Sir John Lubbock
Languange : en
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Treatise On Human Physiology

Author by : Henry Cadwalader Chapman
Languange : en
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Total Read : 22
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A Text Book Of Human Physiology

Author by : Leonard Landois
Languange : en
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Total Read : 48
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A Short History Of Chemistry

Author by : Francis Preston Venable
Languange : en
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Scientific Opinion

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Languange : en
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