Scientific Principles of Adipose Stem Cells

Scientific Principles of Adipose Stem Cells
Author: Lauren Kokai,Kacey Marra,J. Peter Rubin
Publsiher: Academic Press
Total Pages: 484
Release: 2021-09-01
ISBN: 0128193778
Category: Science
Language: EN, FR, DE, ES & NL

Scientific Principles of Adipose Stem Cells Book Excerpt:

Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications

Biomaterials and Stem Cells in Regenerative Medicine

Biomaterials and Stem Cells in Regenerative Medicine
Author: Murugan Ramalingam,Seeram Ramakrishna,Serena Best
Publsiher: CRC Press
Total Pages: 564
Release: 2012-07-03
ISBN: 1439879257
Category: Medical
Language: EN, FR, DE, ES & NL

Biomaterials and Stem Cells in Regenerative Medicine Book Excerpt:

Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Biomaterials and Stem Cells in Regenerative Medicine explores a range of applications for biomaterials and stem cell therapy and describes recent research on suitable cell scaffolds and substrates for tissue repair and reconstruction. Featuring contributions by experts in the field, the book explores important scientific and clinical aspects. It covers the basic science involved in structure and properties, techniques and technological innovations in processing and characterization, and applications of biomaterials and stem cells. Topics include: Polymeric systems for stem cell delivery The potential of membranes and porous scaffolds in tissue repair, including myocardial, periodontal, ophthalmic, and bone tissues The optimization of the interaction between stem cells and biomaterial substrates The source and nature of stem cells for tissue engineering applications The clinical translation of stem cell–based tissue engineering for regenerative medicine From fundamental principles to recent advances at the macro, micro, nano, and molecular scales, the book brings together current knowledge on biomaterials and stem cells in the context of regenerative medicine. It also stimulates discussion about future research directions. This unique book offers a valuable benchmark for the current status of clinically relevant research and development in stem cells and regenerative medicine. It bridges the gaps in experimental approaches and understanding among the materials science and engineering, biological sciences, and biomedical science and engineering communities, making it a valuable reference for graduate students, researchers, and practitioners working in the multidisciplinary field of biomedical research.

Principles of Regenerative Medicine

Principles of Regenerative Medicine
Author: Anthony Atala,Robert Lanza,Tony Mikos,Robert Nerem
Publsiher: Academic Press
Total Pages: 1454
Release: 2018-08-09
ISBN: 0128098937
Category: Medical
Language: EN, FR, DE, ES & NL

Principles of Regenerative Medicine Book Excerpt:

Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine

Regenerative Engineering

Regenerative Engineering
Author: Yusuf Khan,Cato T. Laurencin
Publsiher: CRC Press
Total Pages: 154
Release: 2018-04-19
ISBN: 1498738257
Category: Medical
Language: EN, FR, DE, ES & NL

Regenerative Engineering Book Excerpt:

This book focuses on advances made in both materials science and scaffold development techniques, paying close attention to the latest and state-of-the-art research. Chapters delve into a sweeping variety of specific materials categories, from composite materials to bioactive ceramics, exploring how these materials are specifically designed for regenerative engineering applications. Also included are unique chapters on biologically-derived scaffolding, along with 3D printing technology for regenerative engineering. Features: Covers the latest developments in advanced materials for regenerative engineering and medicine. Each chapter is written by world class researchers in various aspects of this medical technology. Provides unique coverage of biologically derived scaffolding. Includes separate chapter on how 3D printing technology is related to regenerative engineering. Includes extensive references at the end of each chapter to enhance further study.

Scientific Advances in Reconstructive Urology and Tissue Engineering

Scientific Advances in Reconstructive Urology and Tissue Engineering
Author: Matthias D. Hofer
Publsiher: Academic Press
Total Pages: 316
Release: 2022-03-31
ISBN: 0323915205
Category: Science
Language: EN, FR, DE, ES & NL

Scientific Advances in Reconstructive Urology and Tissue Engineering Book Excerpt:

Scientific Advances in Reconstructive Urology and Tissue Engineering is a comprehensive overview of reconstructive urology that spans male and female, pediatric, neuro-urology and trauma. Traditionally, this field has been focused solely on surgical principles with little attention to basic and translational research. However, recent advances in acellular matrices, scaffolds, stem cells and tissue engineering have changed this focus. This publication is the perfect bridge and definitive tome of the advances that will move the translational and basic science of reconstructive urology forward and allow readers to implement the findings in clinical practice. Through the use of both current case studies and future implications, the content bridges the gap from bench to bedside making it the perfect reference for translational benign urology researchers who wish to move the field of reconstructive surgery forward. Includes real-world applications of current research to help readers get rapidly up-to-speed on which research results are appropriate for immediate implementation Presents the underlying mechanism of urologic disease processes pertinent to reconstructive urology for comprehensive understanding within the field Provides independent guidance to manage specific clinical conditions while also presenting approaches that are applicable to all conditions

Adipose Stem Cells and Regenerative Medicine

Adipose Stem Cells and Regenerative Medicine
Author: Yves-Gerard Illouz,Aris Sterodimas
Publsiher: Springer Science & Business Media
Total Pages: 278
Release: 2011-09-07
ISBN: 9783642200120
Category: Medical
Language: EN, FR, DE, ES & NL

Adipose Stem Cells and Regenerative Medicine Book Excerpt:

The therapeutic potential of the use of adipose stem cells in regenerative medicine has been increasingly recognized, and in recent years concrete clinical benefits have accrued as these cells have been explored for a variety of applications. This readable and informative textbook tracks the progress that has been made in this fascinating new area of biomedicine. All aspects of the subject are considered, with particular attention to adipose cell biology, adipose tissue engineering strategies, and the diverse clinical applications of adipose stem cells. Funding issues, industrial approaches, regulatory challenges, and future directions are also examined. The two editors have vast experience in the field and have chosen leading experts from different countries to write on each topic. This book will excite the interest of all researchers, clinicians, and students wishing to gain an in-depth understanding of adipose stem cells and their flourishing role in regenerative medicine.

Principles of Tissue Engineering

Principles of Tissue Engineering
Author: Robert Lanza,Robert Langer,Joseph P. Vacanti,Anthony Atala
Publsiher: Academic Press
Total Pages: 1678
Release: 2020-03-26
ISBN: 0128214015
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Principles of Tissue Engineering Book Excerpt:

Now in its fifth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fifth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and the application of tissue-engineering techniques for food production – is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the emerging technologies in the field. Organized into twenty-three parts, covering the basics of tissue growth and development, approaches to tissue and organ design, and a summary of current knowledge by organ system Introduces a new section and chapters on emerging technologies in the field Full-color presentation throughout

Progenitor and Stem Cell Technologies and Therapies

Progenitor and Stem Cell Technologies and Therapies
Author: Anthony Atala
Publsiher: Elsevier
Total Pages: 568
Release: 2012-03-15
ISBN: 0857096079
Category: Medical
Language: EN, FR, DE, ES & NL

Progenitor and Stem Cell Technologies and Therapies Book Excerpt:

Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application. Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair. With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology. Reviews the range of progenitor and stem cells available and outlines their therapeutic application Examines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells Includes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies

Biomaterials Science and Tissue Engineering

Biomaterials Science and Tissue Engineering
Author: Bikramjit Basu
Publsiher: Cambridge University Press
Total Pages: 716
Release: 2017-09-15
ISBN: 1108415156
Category: Medical
Language: EN, FR, DE, ES & NL

Biomaterials Science and Tissue Engineering Book Excerpt:

Covers key principles and methodologies of biomaterials science and tissue engineering with the help of numerous case studies.

Principles of Gender Specific Medicine

Principles of Gender Specific Medicine
Author: Marianne J. Legato
Publsiher: Academic Press
Total Pages: 792
Release: 2017-05-15
ISBN: 0128035420
Category: Medical
Language: EN, FR, DE, ES & NL

Principles of Gender Specific Medicine Book Excerpt:

The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation. This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness. Outlines sex-specific differences in normal human function and explains the impact of age, hormones, and environment on the incidence and outcome of illness Reflects the latest information about the molecular basis of the sexual dimorphism in human physiology and the experience of disease Reviews the implications of our ever-improving ability to describe the genetic basis of vulnerability to disease and our capacity to alter the genome itself Illustrates the importance of new NIH guidelines that urge the inclusion of sex as a variable in research protocols

Stem Cells in Veterinary Science

Stem Cells in Veterinary Science
Author: Ratan Kumar Choudhary,Shanti Choudhary
Publsiher: Springer Nature
Total Pages: 375
Release: 2022-02-05
ISBN: 9811634645
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cells in Veterinary Science Book Excerpt:

This book explores the potential applications of animal stem cells in veterinary medicine. It begins with an overview of stem cells and their application in treating various animal diseases, including mastitis. In turn, the book discusses the challenges of using stem cells in regenerative medicine and emphasizes the importance of understanding the action of stem cells and preclinical evidence for ensuring safety and therapeutic efficacy. It also presents methods for the identification, characterization, and quantification of stem cells. Further, it discusses the therapeutic applications of different stem cells, including milk-derived, testicular, and mesenchymal stem cells in veterinary medicine. Lastly, it discusses strategies for and therapeutic applications of genome editing by CRISPER/Cas9 in mammary stem cells. As such, the book offers a valuable resource for students and scientists working in the veterinary sciences and veterinarians.

Plastic Surgery Principles and Practice E Book

Plastic Surgery   Principles and Practice E Book
Author: Rostam Farhadieh,Neil Bulstrode,Babak J. Mehrara,Sabrina Cugno
Publsiher: Elsevier Health Sciences
Total Pages: 924
Release: 2021-04-22
ISBN: 0323653820
Category: Medical
Language: EN, FR, DE, ES & NL

Plastic Surgery Principles and Practice E Book Book Excerpt:

With detailed, expert guidance on each essential topic, Plastic Surgery: Principles and Practice offers single-volume convenience without sacrificing complete coverage of this multi-faceted field. Written by global leading authorities, it provides concise, easy-to-follow instruction with the clinical details and supportive data needed to achieve optimal patient outcomes. Offers thorough coverage of facelift procedures, rhinoplasty, otoplasty and more, along with clinical pearls from masters in the field. Features hundreds of high-quality images including anatomical line art, case photos, and procedural operative photos. I Includes a superb selection of procedural videos of global experts performing key techniques within operating room and close-up clinical pearls. An ideal resource for residents, fellows, and practitioners in plastic surgery, as well as those in otolaryngology, vascular surgery, and cosmetic dermatology.

Regenerative Medicine and Tissue Engineering

Regenerative Medicine and Tissue Engineering
Author: Daniel Eberli
Publsiher: IntechOpen
Total Pages: 604
Release: 2011-08-29
ISBN: 9789533076638
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Regenerative Medicine and Tissue Engineering Book Excerpt:

Tissue Engineering may offer new treatment alternatives for organ replacement or repair deteriorated organs. Among the clinical applications of Tissue Engineering are the production of artificial skin for burn patients, tissue engineered trachea, cartilage for knee-replacement procedures, urinary bladder replacement, urethra substitutes and cellular therapies for the treatment of urinary incontinence. The Tissue Engineering approach has major advantages over traditional organ transplantation and circumvents the problem of organ shortage. Tissues reconstructed from readily available biopsy material induce only minimal or no immunogenicity when reimplanted in the patient. This book is aimed at anyone interested in the application of Tissue Engineering in different organ systems. It offers insights into a wide variety of strategies applying the principles of Tissue Engineering to tissue and organ regeneration.

A Roadmap to Nonhematopoietic Stem Cell Based Therapeutics

A Roadmap to Nonhematopoietic Stem Cell Based Therapeutics
Author: Xiao-Dong Chen
Publsiher: Academic Press
Total Pages: 544
Release: 2018-08-31
ISBN: 0128119217
Category: Science
Language: EN, FR, DE, ES & NL

A Roadmap to Nonhematopoietic Stem Cell Based Therapeutics Book Excerpt:

A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent. Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy Discusses a wide array of pressing clinical issues with stem cell-based therapies so that new ideas in the laboratory can be efficiently translated to the clinic through better designed clinical trials Helps clarify current regulatory mechanisms so that the safe use of stem cells for treating a variety of diseases can move forward Fosters cross-disciplinary dialogue between research scientists and physicians to accelerate the safe implementation of efficacious cell therapies

Mesenchymal Stem Cells Basics and Clinical Application II

Mesenchymal Stem Cells   Basics and Clinical Application II
Author: Birgit Weyand,Massimo Dominici,Ralf Hass,Roland Jacobs,Cornelia Kasper
Publsiher: Springer
Total Pages: 309
Release: 2014-07-08
ISBN: 3642379443
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cells Basics and Clinical Application II Book Excerpt:

Engineered MSCs from Patient-Specific iPS Cells, by Irina Eberle, Mohsen Moslem, Reinhard Henschler, Tobias Cantz Fate of Intravenously Injected Mesenchymal Stem Cells and Significance for Clinical Application, by Beate Wagner, Reinhard Henschler The Implications of Stem Cell Applications for Diseases of the Respiratory System, by Mei Ling Lim, Philipp Jungebluth, Paolo Macchiarini Potential of Mesenchymal Stem Cell Applications in Plastic and Reconstructive Surgery, by Birgit Weyand, Peter M. Vogt General Principles for the Regeneration of Bone and Cartilage, by Michael Jagodzinski, C. Haasper Adult Mesenchymal Stem Cells Explored in the Dental Field, by K. M. Fawzy El-Sayed, C. Dörfer, F. Fändrich, F. Gieseler, M. H. Moustafa, H. Ungefroren Mesenchymal Stem Cell Therapy and Lung Diseases, by Khondoker M. Akram, Sohel Samad, Monica Spiteri, Nicholas R. Forsyth Mesenchymal Stem Cells as Cellular Immunotherapeutics in Allogeneic Hematopoietic Stem Cell Transplantation, by Claudia Papewalis, Daniela Topolar, Barbara Götz, Stefan Schönberger, Dagmar Dilloo New Cell-Based Therapy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and Anti-inflammatory MSC2 Phenotypes, by Aline M. Betancourt Interactions Between Mesenchymal Stem Cells and Dendritic Cells, by Grazia Maria Spaggiari, Lorenzo Moretta MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential, by Naomi D’souza, Jorge Sans Burns, Giulia Grisendi, Olivia Candini, Elena Veronesi, Serena Piccinno, Edwin M. Horwitz, Paolo Paolucci, Pierfranco Conte, Massimo Dominici Sources of Mesenchymal Stem Cells: Current and Future Clinical Use, by Michela Pozzobon, Martina Piccoli, Paolo De Coppi Role of the EU Framework in Regulation of Stem Cell-Based Products, by Giovanni Migliaccio, Cristina Pintus

Preservation of Cells

Preservation of Cells
Author: Allison Hubel
Publsiher: John Wiley & Sons
Total Pages: 216
Release: 2018-02-13
ISBN: 1118989848
Category: Science
Language: EN, FR, DE, ES & NL

Preservation of Cells Book Excerpt:

Helps those that use cell preservation to develop new protocols or improve existing protocols This book provides readers with the tools needed to develop or debug a preservation protocol for cells. The core structure and content of the text grew from a professional short course that has been offered at the Biopreservation Core Resource for the last 10 years. This comprehensive text describes, step by step, the individual elements of a protocol, including the relevant scientific principles for each phase of the protocol. It can be used by anyone who is involved in cell preservation—even by those who are not experts in freezing of cells—because it provides the scientific basis for those that want to understand the basis for the protocol. Preservation of Cells: A Practical Manual begins by first introducing readers to the subject of preserving cells. It then goes on to cover Pre-freeze Processing and Characterization; Formulation and Introduction of Cryopreservation Solutions; Freezing Protocols; Storage and Shipping of Frozen Cells; Thawing and Post Thaw Processing; Post-thaw Assessment; and Algorithm-driven Protocol Optimization. Clearly explains the reasons behind every step in the development of a preservation protocol and the scientific principles behind them Provides alternative modes of preservation for when conventional methods of cryopreservation are not appropriate for a given cell type or application Enables more organization to achieve improved post thaw recoveries and process consistency Preservation of Cells: A Practical Manual is an important book for researchers, laboratory technicians and students in cell biology, stem cell biology, tissue engineering, and regenerative medicine. It is also useful to cell bankers, regenerative medicine, biomarker discovery or precision medicine companies, and cell therapy labs, blood bankers, biobankers, and biotechnology companies.

Principles of Translational Science in Medicine

Principles of Translational Science in Medicine
Author: Martin Wehling
Publsiher: Academic Press
Total Pages: 494
Release: 2021-07-15
ISBN: 032399962X
Category: Science
Language: EN, FR, DE, ES & NL

Principles of Translational Science in Medicine Book Excerpt:

Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields. Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization

Stem Cell Bioprocessing and Manufacturing

Stem Cell Bioprocessing and Manufacturing
Author: Joaquim M. S. Cabral,Cláudia Lobato da Silva,Maria Margarida Diogo
Publsiher: MDPI
Total Pages: 170
Release: 2021-01-20
ISBN: 3039430386
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cell Bioprocessing and Manufacturing Book Excerpt:

The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies.

Biology and Engineering of Stem Cell Niches

Biology and Engineering of Stem Cell Niches
Author: Ajaykumar Vishwakarma,Jeffrey M Karp
Publsiher: Academic Press
Total Pages: 642
Release: 2017-03-22
ISBN: 0128027568
Category: Science
Language: EN, FR, DE, ES & NL

Biology and Engineering of Stem Cell Niches Book Excerpt:

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Adipose Derived Stem Cells ASCs for Tissue Engineering

Adipose Derived Stem Cells  ASCs  for Tissue Engineering
Author: Mathias Tremp,Daniel Eberli,Rita Gobet,Souzan Salemi,Tullio Sulser
Publsiher: Unknown
Total Pages: 135
Release: 2011
ISBN: 9789533076638
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Adipose Derived Stem Cells ASCs for Tissue Engineering Book Excerpt: