Molecular Mechanisms of Signal Transduction

Molecular Mechanisms of Signal Transduction
Author: Johannes Lukas Bos
Publsiher: Unknown
Total Pages: 285
Release: 2000
ISBN: 1928374650XXX
Category: Cell adhesion molecules
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Signal Transduction Book Excerpt:

This book contains overviews of topics that have been discussed. It includes contributions from leading experts in the field on small GTPases, protein kinases and transcription factors. A particular focus was the influence of oxygen radicals on signalling processes. It also contains the contribution of scientists early in their career, who have made an exccellent contribution to the institute."

Cytoskeletal membrane Interactions and Signal Transduction

Cytoskeletal membrane Interactions and Signal Transduction
Author: Pam Cowin,Michael Klymkowsky
Publsiher: Landes Bioscience
Total Pages: 268
Release: 1997
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Cytoskeletal membrane Interactions and Signal Transduction Book Excerpt:

Heat Stress Signal Transduction in Plant Cells

Heat Stress Signal Transduction in Plant Cells
Author: Ahmed Mansour
Publsiher: VDM Publishing
Total Pages: 112
Release: 2008
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Heat Stress Signal Transduction in Plant Cells Book Excerpt:

Plant tolerance to heat stress proved to be entirely dependent on the signa-ling flow of information by which the plant can sense the changes in its surrounding environment and signal its genes to respond by producing special proteins to protect it-self. Any changes or manipulations in this signaling flow of information will presumably lead to a modification in the genetic expression inside the plant cells, consequently, changing plant per-formance. Understanding these signaling events in response to heat may help us to produce heat tolerant plants capable to stand high temperature stress. In the present investigation, the results showed that a heat activated MAP kinase cascade, involving heat activated MAP kinase (HAMK), played an essential role in heat shock gene expression in tobacco BY-2 cells. In order to determine if heat activation of HAMK involved additional pathways of signaling we studied the upstream regulation of HAMK, including membrane fluidization and reorganization of cytoskeleton. The activation of HAMK and accumulation of heat responsive HSFs, HSP70 and HSP27 proteins were used as end-point markers in these experiments. It is concluded that the heat shock response, as measured by HAMK activation and heat shock proteins accu-mulation required PKC activation, membrane fluidization and reorganization of the cytoskeleton. A comparative bioinformatic explanation of similarities between tobacco heat shock genes and their counterparts in different organisms revealed a high degree of evolutionary conservation in the corres-ponding domains, indicating similar function in different species.

Principles of Signal Transduction and Gene Circuit Design Governing Nitrogen Assimilation in Escherichia Coli

Principles of Signal Transduction and Gene Circuit Design Governing Nitrogen Assimilation in Escherichia Coli
Author: Timothy Allen Blauwkamp
Publsiher: Unknown
Total Pages: 135
Release: 2003
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Principles of Signal Transduction and Gene Circuit Design Governing Nitrogen Assimilation in Escherichia Coli Book Excerpt:

Signal Transduction

Signal Transduction
Author: Bastien D. Gomperts,ljsbrand M. Kramer,Peter E.R. Tatham
Publsiher: Academic Press
Total Pages: 840
Release: 2009-09-22
ISBN: 9780080919058
Category: Science
Language: EN, FR, DE, ES & NL

Signal Transduction Book Excerpt:

Signal Transduction, 2e, is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction, 2e, serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention In-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors; tyrosine protein kinases and adaptive immunity; and intracellular calcium Extensive conceptual color artwork to assist with comprehension of key topics Instrumental margin notes highlight milestones in signaling mechanisms

Signal Transduction in Cancer Metastasis

Signal Transduction in Cancer Metastasis
Author: Wen-Sheng Wu,Chi-Tan Hu
Publsiher: Springer Science & Business Media
Total Pages: 288
Release: 2010-10-04
ISBN: 9789048195220
Category: Medical
Language: EN, FR, DE, ES & NL

Signal Transduction in Cancer Metastasis Book Excerpt:

This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.

Signal Transduction in the Retina

Signal Transduction in the Retina
Author: Steven J. Fliesler,Oleg G. Kisselev
Publsiher: CRC Press
Total Pages: 408
Release: 2007-12-26
ISBN: 9781420007169
Category: Science
Language: EN, FR, DE, ES & NL

Signal Transduction in the Retina Book Excerpt:

In the twenty-first century, we are just beginning to understand more clearly the enormous diversity and complexity of signaling processes in the retina. Integrating advances in the biochemistry, cell biology, physiology, and physics of phototransduction, Signal Transduction in the Retina presents the methodologies and experimental approaches that yield key information on the mechanisms underlying normal retinal physiology. This in-depth work discusses the latest techniques and applications for understanding retinal function and degradation, developing novel therapeutic strategies, and promoting cellular survival and functional retention. Drawing contributions from experts in a range of disciplines, each chapter presents a brief overview of the area discussed along with specific methodology for obtaining the primary data to understand the cellular and molecular process. Given the dominance and wealth of information on rhodopsin-based phototransduction, the book devotes substantial attention to this topic, but also evaluates a diversity of signaling mechanisms. Beginning with the molecular mechanisms of vertebrate phototransduction, this volume presents the structure of phototransduction cascade components at atomic resolution, as well as molecular interactions in multi-protein complexes and novel cell-based strategies for understanding signal shut-off and light adaptation. It discusses non-visual phototransduction and the role of melanopsin in adaptive photoresponses and circadian clock regulation. The book also compares the visual signaling processes of vertebrates and invertebrates. It examines experimental studies of insulin-based signaling in the inner and outer retina; investigates retinal development including signaling in progenitor cells, cell-cell communication in developing cells, and neovascularization; and studies lipid-derived mediators such as neuroprotectins and discusses the participation of retinal pigment epithelium in neuronal survival.

Plant Signal Transduction

Plant Signal Transduction
Author: Dierk Scheel,Claus Wasternack
Publsiher: Oxford University Press
Total Pages: 324
Release: 2002-03-28
ISBN: 9780199638796
Category: Nature
Language: EN, FR, DE, ES & NL

Plant Signal Transduction Book Excerpt:

Plant growth and development is controlled by environmental cues (e.g. light, salinity) that are sensed by the plant via a variety of signal transduction pathways. This book gives an up-to-date summary of the large amount of information that is now available on the processes involved in the communication of plants with their environment.

Signal Transduction

Signal Transduction
Author: Carl-Henrik Heldin,Mary Purton
Publsiher: Garland Science
Total Pages: 365
Release: 1998
ISBN: 9780748740741
Category: Science
Language: EN, FR, DE, ES & NL

Signal Transduction Book Excerpt:

Signal Transduction was published in association with The International Union of Biochemistry and Molecular Biology. In a series of twenty-three short chapters, leading researchers provide cutting-edge reviews of signal transduction, and form cell membrane receptors through to gene regulation. Written for those with a basic understanding of molecular and cell biology, the book will be of particular interest to graduate students and researchers who need to grasp the principles of signal transduction.

Signal Transduction

Signal Transduction
Author: Ijsbrand M. Kramer
Publsiher: Academic Press
Total Pages: 1104
Release: 2015-10-23
ISBN: 0123948193
Category: Science
Language: EN, FR, DE, ES & NL

Signal Transduction Book Excerpt:

A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor – ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail. Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition. In-depth insight into a subject central to cell biology and fundamental to biomedicine, including the search for novel therapeutic interventions Essential signaling events embedded in rich physiological and pathological contexts Extensive conceptual colour artwork to assist with comprehension of key topics Special emphasis on how molecular structure determines protein function and subcellular localization Employment of unambiguous protein names (symbols) in agreement with leading protein- and gene databases, allowing the learner to extend his/her exploration on the web

Signal Transduction

Signal Transduction
Author: Gerard Meurant
Publsiher: Academic Press
Total Pages: 463
Release: 2012-12-02
ISBN: 0323139124
Category: Science
Language: EN, FR, DE, ES & NL

Signal Transduction Book Excerpt:

An explosion of information has occurred over the past few years in the field of signal transduction. As information form prokaryotes and eukaryotes has accumulated, it has become evident that diverse sensory systems share common mechanistic themes. This volume reviews our the current knowledge of molecular mechanisms for sensory transduction in a variety of microbial systems, as well as elegant work done in nematodes and Drosophila. Signal Transduction is intended for both researchers studying microbial systems and investigators and students of signal transduction in more complex organisms, who can learn from the paradigms and mechanisms conserved between prokaryotes and eukaryotes.

Calmodulin and Signal Transduction

Calmodulin and Signal Transduction
Author: Linda J. Van Eldik,D. Martin Watterson
Publsiher: Gulf Professional Publishing
Total Pages: 482
Release: 1998
ISBN: 0127138609
Category: Medical
Language: EN, FR, DE, ES & NL

Calmodulin and Signal Transduction Book Excerpt:

This book focuses on emerging themes in the molecular mechanisms of calcium signal transduction through calmodulin-regulated pathways. It provides the reader with selected examples and experimental precedents that underlie current models of cell regulation through calmodulin-regulated pathways and their linkage with other regulatory pathways. Contents - L.J. Van Eldik and D.M. Watterson, 'Calmodulin and Calcium Signal Transduction - An Introduction'. M.R. Nelson and W.J. Chazin, 'Calmodulin as a Calcium Sensor'. T.J. Lukas, S. Mirzoeva, and D.M. Watterson, 'Calmodulin-Regulated Protein Kinases'. B.A. Perrino and T.R. Soderling, 'Biochemistry and Pharmacology of Calmodulin-Regulated Phosphatase Calcineurin'. W.K. Sonnenburg, G.A. Wayman, D.R. Storm, and J.A. Beavo, 'Cyclic Nucleotide Regulation by Calmodulin'. J. Hu and L.J. Van Eldik, 'Regulation of Nitric Oxide Synthase by Calmodulin'. N.M. Bonafe and J.R. Sellers, 'Calmodulin-Binding Proteins of the Cytoskeleton'. P.C. Brandt and T.C. Vanaman, 'Calmodulin and Ion Flux Regulation'. Subject Index.

Signal Transduction and Smooth Muscle

Signal Transduction and Smooth Muscle
Author: Mohamed Trebak,Scott Earley
Publsiher: CRC Press
Total Pages: 412
Release: 2018-08-06
ISBN: 1351650610
Category: Medical
Language: EN, FR, DE, ES & NL

Signal Transduction and Smooth Muscle Book Excerpt:

All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling. Key selling features: Focuses on smooth muscles of different types Describes ion channel signaling mechanisms Reviews calcium and receptor signaling Includes novel, cutting-edge methodologies Summarizes studies of mice with genetically encoding sensors in smooth muscle

Signal Transduction Research Trends

Signal Transduction Research Trends
Author: Nickolas O. Grachevsky
Publsiher: Nova Publishers
Total Pages: 311
Release: 2007
ISBN: 9781600214875
Category: Science
Language: EN, FR, DE, ES & NL

Signal Transduction Research Trends Book Excerpt:

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Signals and Signal Transduction Pathways in Plants

Signals and Signal Transduction Pathways in Plants
Author: Klaus Palme
Publsiher: Springer Science & Business Media
Total Pages: 452
Release: 2012-12-06
ISBN: 9401102392
Category: Science
Language: EN, FR, DE, ES & NL

Signals and Signal Transduction Pathways in Plants Book Excerpt:

Plants offer exciting opportunities to understand major biological questions, i.e. the regulation of development and morphogenesis. How are changes of the environment, developmental cues, and other signals perceived and transduced in physiological responses? What are the elements of plant signalling pathways and what is their organization? The panoply of molecular tools and techniques as well as the blossoming field of plant genetics are providing an exciting ground for major breakthroughs in unravelling the fundamental mechanisms of plant signalling. The present book establishes a state-of-the-art framework spanning the wide spectrum of perception, signal transduction events and transport processes, including cell proliferation and cell cycle regulation, embryogenesis, and flowering. Moreover, the volume emphasizes the role of the major plant signalling substances known to date (the phytohormones and more recently studied substances) and summarizes what we know on their molecular mechanisms of action. The book emphasizes how the use of molecular technology has made plant signalling processes accessible to experimental test.

Signal Transduction and Human Disease

Signal Transduction and Human Disease
Author: Toren Finkel,J. Silvio Gutkind
Publsiher: John Wiley & Sons
Total Pages: 488
Release: 2003-07-18
ISBN: 0471448370
Category: Science
Language: EN, FR, DE, ES & NL

Signal Transduction and Human Disease Book Excerpt:

This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.

Signal Transduction in Mast Cells and Basophils

Signal Transduction in Mast Cells and Basophils
Author: Ehud Razin,Juan Rivera
Publsiher: Springer Science & Business Media
Total Pages: 423
Release: 2012-12-06
ISBN: 1461221544
Category: Science
Language: EN, FR, DE, ES & NL

Signal Transduction in Mast Cells and Basophils Book Excerpt:

Focussing on the molecular mechanisms that govern mast cell and basophil cell biology and function, this book also provides a comprehensive summary of the field of signal transduction, giving insights into areas that have therapeutic potential. It gives detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide readers with an up-to-date account of a topic whose rapid progress makes conventional information gathering difficult.

Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Signal Transduction and the Coordination of B Lymphocyte Development and Function I
Author: Louis B. Justement,Katherine A. Siminovitch
Publsiher: Springer Science & Business Media
Total Pages: 267
Release: 2012-12-06
ISBN: 3642570666
Category: Medical
Language: EN, FR, DE, ES & NL

Signal Transduction and the Coordination of B Lymphocyte Development and Function I Book Excerpt:

Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.

Intracellular Signal Transduction The JAK STAT Pathway

Intracellular Signal Transduction  The JAK STAT Pathway
Author: Andrew F. Wilks,Ailsa G. Harpur
Publsiher: Springer Science & Business Media
Total Pages: 209
Release: 2013-06-29
ISBN: 3662220504
Category: Science
Language: EN, FR, DE, ES & NL

Intracellular Signal Transduction The JAK STAT Pathway Book Excerpt:

This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.

Airways Smooth Muscle Peptide Receptors Ion Channels and Signal Transduction

Airways Smooth Muscle  Peptide Receptors  Ion Channels and Signal Transduction
Author: David Raeburn,Mark A. Giembycz
Publsiher: Springer
Total Pages: 278
Release: 2012-12-06
ISBN: 303487362X
Category: Medical
Language: EN, FR, DE, ES & NL

Airways Smooth Muscle Peptide Receptors Ion Channels and Signal Transduction Book Excerpt: