Site Specific and Global Epigenomic Editing

Site Specific and Global Epigenomic Editing
Author: Feng C Zhou
Publsiher: Academic Press
Total Pages: 704
Release: 2022-06-15
ISBN: 9780128193983
Category: Medical
Language: EN, FR, DE, ES & NL

Site Specific and Global Epigenomic Editing Book Excerpt:

In recent years, alongside the largely popularized advances in human genome editing and CRISPR-cas9-driven therapeutics, epigenomic editing has made strong strides, though a clear understanding is still forming in the field of the exact role that epigenetics play in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. Key questions for researchers embarking in this field include: Which of the hundreds of epigenomic marks and features are relevant, and which of those are likely to serve a role in regulating gene expression, cell behavior, and phenotypic outcomes? This volume is the first to provide a thorough, conceptual introduction to the field of epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Protocols, and applied case studies examine early disease targets and likely pathways of therapeutic significance, while also outlining common challenges in the field, and the addressing the range of bioethical questions that come with altering phenotypes. This book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research. Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery Discusses fundamental theory, experimental design, and applied approaches alongside common research challenges and bioethical concerns Examines epigenomic editing's potential role in modulation of developmental, neuropsychiatric, and immunological disorders, as well as viral infections and cancer

Quantitative Genetics Genomics and Plant Breeding 2nd Edition

Quantitative Genetics  Genomics and Plant Breeding  2nd Edition
Author: Manjit S. Kang
Publsiher: CABI
Total Pages: 431
Release: 2020-04-01
ISBN: 1789240212
Category: Science
Language: EN, FR, DE, ES & NL

Quantitative Genetics Genomics and Plant Breeding 2nd Edition Book Excerpt:

This book presents state-of-the-art, authoritative chapters on contemporary issues in the broad areas of quantitative genetics, genomics and plant breeding. Section 1 (Chapters 2 to 12) emphasizes the application of genomics, and genome and epigenome editing techniques, in plant breeding; bioinformatics; quantitative trait loci mapping; and the latest approaches of examining and exploiting genotype-environment interactions. Section 2 (Chapters 13 to 20) represents the intersection of breeding, genetics and genomics. This section describes the use of cutting-edge molecular breeding and quantitative genetics techniques in wheat, rice, maize, root and tuber crops and pearl millet. Overall, the book focuses on using genomic information to help evaluate traits that can combat biotic/abiotic stresses, genome-wide association mapping, high-throughput genotyping/phenotyping, biofortification, use of big data, orphan crops, and gene editing techniques. The examples featured are taken from across crop science research and cover a wide geographical base.

DNA Methyltransferases Role and Function

DNA Methyltransferases   Role and Function
Author: Albert Jeltsch,Renata Z. Jurkowska
Publsiher: Springer
Total Pages: 535
Release: 2016-11-08
ISBN: 3319436244
Category: Science
Language: EN, FR, DE, ES & NL

DNA Methyltransferases Role and Function Book Excerpt:

DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.

Dementia and Neurodegenerative Diseases Editor s Pick 2021

Dementia and Neurodegenerative Diseases Editor s Pick 2021
Author: Bruce Miller
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-09-28
ISBN: 2889713938
Category: Medical
Language: EN, FR, DE, ES & NL

Dementia and Neurodegenerative Diseases Editor s Pick 2021 Book Excerpt:

Reprogramming the Genome CRISPR Cas based Human Disease Therapy

Reprogramming the Genome  CRISPR Cas based Human Disease Therapy
Author: Anonim
Publsiher: Academic Press
Total Pages: 390
Release: 2021-06-12
ISBN: 0323853242
Category: Science
Language: EN, FR, DE, ES & NL

Reprogramming the Genome CRISPR Cas based Human Disease Therapy Book Excerpt:

Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy, presents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 is a key technology for targeted genome editing and regulation in a number of organisms including mammalian cells. It is a rapid, simple, and cost-effective solution. CRISPR-Cas system has recently gained much scientific and public attention. This volume covers CRISPR-Cas9 based mammalian genome editing, creating disease models, cancer therapy, neurological, heredity, blood disorders, defective gene correction, stem cells therapy, epigenetic modifications, patents, ethics, biosafety and regulatory issues challenges and opportunities. This book is a key source of information on mammalian genome editing available in a single volume. This book will be useful for beginners in mammalian genome editing and also students, researchers, scientists, policymakers, clinicians and stakeholders interested in genome editing in several areas. Offers basic understanding and a clear picture of mammalian genome editing through CRISPR-Cas systems Discusses how to create mammalian disease models, stem cell modification, epigenetic modifications, correction of defective gene in blood disorders, heredity, neurological disorders and many more Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology, translational sciences, neurobiology, neurology, cancer, stem cells, and many more

Chromatin and Epigenetics

Chromatin and Epigenetics
Author: Colin Logie,Tobias Aurelius Knoch
Publsiher: BoD – Books on Demand
Total Pages: 294
Release: 2020-01-29
ISBN: 1789844924
Category: Science
Language: EN, FR, DE, ES & NL

Chromatin and Epigenetics Book Excerpt:

Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields of epigenetics and chromatin ranging from more theoretical overviews in the first four chapters to much more detailed methodologies and insights into diagnostics and treatments in the following chapters. The chapters illustrate in their depth and breadth that genetic information is stored on all structural and dynamical levels within the nucleus with corresponding modifications of functional relevance. Thus, only an integrative systems approach allows to understand, treat, and manipulate the holistic interplay of genotype and phenotype creating functional genomes. The book chapters therefore contribute to this general perspective, not only opening opportunities for a true universal view on genetic information but also being key for a general understanding of genomes, their function, as well as life and evolution in general.

Neuroepigenomics in Aging and Disease

Neuroepigenomics in Aging and Disease
Author: Raul Delgado-Morales
Publsiher: Springer
Total Pages: 525
Release: 2017-05-18
ISBN: 3319538896
Category: Science
Language: EN, FR, DE, ES & NL

Neuroepigenomics in Aging and Disease Book Excerpt:

Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

Molecular Breeding in Wheat Maize and Sorghum

Molecular Breeding in Wheat  Maize and Sorghum
Author: Mohammad Anwar Hossain,Mobashwer Alam,Saman Seneweera,Sujay Rakshit,Robert J. Henry
Publsiher: CABI
Total Pages: 550
Release: 2021-06-30
ISBN: 1789245435
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Molecular Breeding in Wheat Maize and Sorghum Book Excerpt:

The global population is projected to reach almost 10 billion by 2050, and food and feed production will need to increase by 70%. Wheat, maize and sorghum are three key cereals which provide nutrition for the majority of the world's population. Their production is affected by various abiotic stresses which cause significant yield losses. The effects of climate change also increase the frequency and severity of such abiotic stresses. Molecular breeding technologies offer real hope for improving crop yields. Although significant progress has been made over the last few years, there is still a need to bridge the large gap between yields in the most favorable and most stressful conditions.

Mutation Specific Gene Editing for Blood Disorders

Mutation Specific Gene Editing for Blood Disorders
Author: Carsten Werner Lederer,Pietro Genovese,Annarita Miccio,Sjaak Philipsen
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-11-25
ISBN: 2889716880
Category: Science
Language: EN, FR, DE, ES & NL

Mutation Specific Gene Editing for Blood Disorders Book Excerpt:

Dr. Miccio holds patents related to viral gene delivery vectors. The Topic Editors acknowledge the use of image material from kindpng.com and from Crystal and Annie Spratt on unsplash.com.

Past Present and Future Trends in Cotton Breeding

Past  Present and Future Trends in Cotton Breeding
Author: Mehboob-Ur- Rahman,Yusuf Zafar
Publsiher: BoD – Books on Demand
Total Pages: 184
Release: 2018-05-02
ISBN: 1789230764
Category: Medical
Language: EN, FR, DE, ES & NL

Past Present and Future Trends in Cotton Breeding Book Excerpt:

Cotton, a source of natural fiber for textile industry, has a long breeding history aiming at increasing cotton fiber yield and its quality. Newly developed cotton varieties poorly respond in low-input environments. Secondly, the impact of changing climate may threaten the cotton production in the future. To address these challenges, efforts toward the development of resilient cotton varieties have been initiated using genetic and modern genomic approaches. In this book, research updates on cotton fiber types and properties, DNA markers for selecting desirable cotton plants, and cotton fiber genomics were compiled. Also, the modern breeding trends including development of transgenic cotton and the biosafety studies and possibilities of improving cotton genome using modern genome editing tools were also compressively discussed.

Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1

Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1
Author: Anirudh Kumar,Rakesh Kumar,Pawan Shukla,Manish K. Pandey
Publsiher: Springer Nature
Total Pages: 297
Release: 2021-05-13
ISBN: 9811608318
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1 Book Excerpt:

Increasing world population, unpredictable climate and various kind of biotic and abiotic stresses necessitate the sustainable increase in crop production through developing improved cultivars possessing enhanced genetic resilience against all odds. An exploration of these challenges and near possible solution to improve yield is addressed in this book. It comprehensively and coherently reviews the application of various aspect of rapidly growing omics technology including genomics, proteomics, transcriptomics and metabolomics for crop development. It provides detailed examination of how omics can help crop science and introduces the benefits of using these technologies to enhance crop production, resistance and other values. It also provides platform to ponder upon the integrative approach of omics to deal with complex biological problems. The book highlights crop improvement such as yield enhancement, biotic and abiotic resistance, genetic modification, bioremediation, food security etc. It explores how the different omics technology independently and collectively would be used to improve the quantitative and qualitative traits of crop plants. The book is useful for graduate and post-graduate students of life science including researchers who are keen to know about the application of omics technologies in the different area of plant science. This book is also an asset to the modern plant breeders, and agriculture biotechnologist.

Human Neural Stem Cells

Human Neural Stem Cells
Author: Leonora Buzanska
Publsiher: Springer
Total Pages: 329
Release: 2018-09-12
ISBN: 3319934856
Category: Science
Language: EN, FR, DE, ES & NL

Human Neural Stem Cells Book Excerpt:

This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.

Medicinal and Aromatic Plants

Medicinal and Aromatic Plants
Author: Tariq Aftab,Khalid Rehman Hakeem
Publsiher: Academic Press
Total Pages: 464
Release: 2020-05-12
ISBN: 0128227753
Category: Science
Language: EN, FR, DE, ES & NL

Medicinal and Aromatic Plants Book Excerpt:

Growing consumer interest in organic and herbal-based products has led to great demand in the botanicals industry in the past few years. However, the growing number of products utilizing medicinal and aromatic plants (MAPs) has threatened an estimated 9,000 medicinal plant species worldwide, making it critical to reevaluate their research and development, production, and utilization. Continuing advances in Omics methodologies and instrumentation are essential to understanding how plants cope with the dynamic nature of their growing environment, how yields and characteristics can be improved, and how to most effectively direct conservation efforts. With a focus on metabolomics, genomics, proteomics, transcriptomics, and more, Medicinal and Aromatic Plants: Expanding Their Horizons through Omics illustrates the genetic mechanisms of MAPs, providing a better understanding of MAPs conservation and methods to improve characteristics for medical applications. With an introduction on the role of MAPs in human health, subsequent chapters discuss using proteomics to increase MAP yields and plant quality, genome editing, and CRISPR/Cas9. A valuable resource for farmers, scientists, chemists, biochemists, pharmacists, and students interested in medicinal and aromatic plants and plant biology, Medicinal and Aromatic Plants: Expanding Their Horizons through Omics ensures readers have the background knowledge to put the necessary methodologies into practice themselves. Includes in-depth analysis of Omics technologies for the enhancement of MAPs Discusses applications of MAPs including their role in human health Written by world-wide leading experts in the field

Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development Progression and Treatment

Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development  Progression  and Treatment
Author: Katherine Chiappinelli,Alejandro Villagra,Lidia Karabon
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-11-30
ISBN: 2889717305
Category: Medical
Language: EN, FR, DE, ES & NL

Genetic and Epigenetic Control on Immune Responses Regulating Molecules in Cancer Development Progression and Treatment Book Excerpt:

Handbook of Epigenetics

Handbook of Epigenetics
Author: Trygve Tollefsbol
Publsiher: Academic Press
Total Pages: 682
Release: 2017-07-10
ISBN: 0128054778
Category: Science
Language: EN, FR, DE, ES & NL

Handbook of Epigenetics Book Excerpt:

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Plant Genome Editing Policies and Governance

Plant Genome Editing     Policies and Governance
Author: Thorben Sprink,Ralf Alexander Wilhelm,Armin Spök,Jürgen Robienski,Stephan Schleissing,Joachim Hermann Schiemann
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-04-22
ISBN: 2889636704
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Plant Genome Editing Policies and Governance Book Excerpt:

Genetics of Male Infertility

Genetics of Male Infertility
Author: Mohamed Arafa,Haitham Elbardisi,Ahmad Majzoub,Ashok Agarwal
Publsiher: Springer Nature
Total Pages: 375
Release: 2020-03-14
ISBN: 3030379728
Category: Health & Fitness
Language: EN, FR, DE, ES & NL

Genetics of Male Infertility Book Excerpt:

This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.

Hormonal Control of Important Agronomic Traits

Hormonal Control of Important Agronomic Traits
Author: Chi-Kuang Wen,Yunde Zhao,Yong-Ling Ruan
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2018-12-21
ISBN: 2889456862
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Hormonal Control of Important Agronomic Traits Book Excerpt:

One of the goals of plant science is to improve agricultural sustainability, increasing yield, food diversity, and nutrition, while minimizing the negative impact on our environment. In response to internal and external cues, plant hormones control various aspects of plant growth and development. The wealth of our knowledge on plant hormones shall greatly advance sustainable agriculture.

Stem Cell Based Therapy for Lung Disease

Stem Cell Based Therapy for Lung Disease
Author: Janette K. Burgess,Irene H. Heijink
Publsiher: Springer Nature
Total Pages: 259
Release: 2019-11-23
ISBN: 303029403X
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cell Based Therapy for Lung Disease Book Excerpt:

This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies. Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung. The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application. This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.

Genomics and Biotechnological Advances in Veterinary Poultry and Fisheries

Genomics and Biotechnological Advances in Veterinary  Poultry  and Fisheries
Author: Yashpal Singh Malik,Debmalya Barh,Vasco Azevedo,S.M. Paul Khurana
Publsiher: Academic Press
Total Pages: 564
Release: 2019-09-14
ISBN: 0128163534
Category: Science
Language: EN, FR, DE, ES & NL

Genomics and Biotechnological Advances in Veterinary Poultry and Fisheries Book Excerpt:

Genomics and Biotechnological Advances in Veterinary, Poultry, and Fisheries is a comprehensive reference for animal biotechnologists, veterinary clinicians, fishery scientists, and anyone who needs to understand the latest advances in the field of next generation sequencing and genomic editing in animals and fish. This essential reference provides information on genomics and the advanced technologies used to enhance the production and management of farm and pet animals, commercial and non-commercial birds, and aquatic animals used for food and research purposes. This resource will help the animal biotechnology research community understand the latest knowledge and trends in this field. Presents biological applications of cattle, poultry, marine and animal pathogen genomics Discusses the relevance of biomarkers to improve farm animals and fishery Includes recent approaches in cloning and transgenic cattle, poultry and fish production