Spinal Cord Injury Pain

Spinal Cord Injury Pain
Author: International Association for the Study of Pain. Research Symposium
Publsiher: International Assn for the Study of Pain
Total Pages: 443
Release: 2002
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

Spinal Cord Injury Pain Book Excerpt:

The Spinal Cord Injury Pain Book

The Spinal Cord Injury Pain Book
Author: Philip Siddall,Rebecca McCabe,Robin Murray,Kathryn Nicholson Perry,Lyndall Katte
Publsiher: Unknown
Total Pages: 203
Release: 2014-11-01
ISBN: 9780987582843
Category: Chronic pain
Language: EN, FR, DE, ES & NL

The Spinal Cord Injury Pain Book Book Excerpt:

One in five people experience chronic pain but for those with spinal cord injury, ongoing pain affects as many as two out of three people and many rate dealing with pain as one of the most difficult consequences of their injury.The Spinal Cord Injury Pain Book is unique in providing the latest information on how pain works as well as addressing the specific pain challenges for people with spinal cord injury.Its practical ?toolbox? offers the best possible answers to pain ranging from medication and new technology through to skills such as exercise, distraction, relaxation and meditation.

Spinal Cord Injury Pain

Spinal Cord Injury Pain
Author: Christine N. Sang,Claire E. Hulsebosch
Publsiher: Elsevier
Total Pages: 510
Release: 2021-10-21
ISBN: 0128186631
Category: Medical
Language: EN, FR, DE, ES & NL

Spinal Cord Injury Pain Book Excerpt:

Spinal Cord Injury Pain presents the basis for preclinical and clinical investigations, along with strategies for new approaches in the treatment of central neuropathic pain. Contributors from the private sector and academia provide a comprehensive review of state-of-the-art research in this challenging space. Topics include Epidemiology of Chronic Pain Following SCI, experimental models and mechanisms of chronic pain in SCI, and new targets and technologies. This book serves as a resource for continued translational research that will result in novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI. Despite a better understanding of the complexity of mechanisms of CNP/SCI, improved medical and surgical management of SCI, and the subsequent acceleration of the identification of new targets and the development of novel analgesics, there is still a great unmet clinical need in the area of CNP following SCI. Hence, this book is a welcomed addition to current research and developments. Provides a comprehensive resource for novel approaches and treatments that improve function and quality of life for individuals with CNP/SCI Includes contributors from the private sector and academia Covers epidemiology of chronic pain following SCI, experimental models, mechanisms of chronic pain in SCI, and new targets and technologies

Neuropathic Pain After Spinal Cord Injury

Neuropathic Pain After Spinal Cord Injury
Author: Dearbhla Burke
Publsiher: Unknown
Total Pages: 464
Release: 2017
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Neuropathic Pain After Spinal Cord Injury Book Excerpt:

Management of Neuropathic Pain After Spinal Cord Injury and Central Post stroke Pain

Management of Neuropathic Pain After Spinal Cord Injury and Central Post stroke Pain
Author: Olaposi Simeon Kehinde
Publsiher: Unknown
Total Pages: 77
Release: 2002
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Management of Neuropathic Pain After Spinal Cord Injury and Central Post stroke Pain Book Excerpt:

Chronic Pain After Spinal Cord Injury

Chronic Pain After Spinal Cord Injury
Author: Holly Boulton
Publsiher: Unknown
Total Pages: 135
Release: 2007
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Chronic Pain After Spinal Cord Injury Book Excerpt:

Analysis of Neuropathic Pain After Spinal Cord Injury

Analysis of Neuropathic Pain After Spinal Cord Injury
Author: Lars Werhagen
Publsiher: Unknown
Total Pages: 47
Release: 2008
ISBN: 9789173574976
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Analysis of Neuropathic Pain After Spinal Cord Injury Book Excerpt:

Spinal Cord Injuries

Spinal Cord Injuries
Author: J.D. Alderson,Elizabeth A.M. Frost
Publsiher: Elsevier
Total Pages: 272
Release: 2016-06-03
ISBN: 1483192067
Category: Medical
Language: EN, FR, DE, ES & NL

Spinal Cord Injuries Book Excerpt:

Spinal Cord Injuries aims to provide information on the problems associated with the treatment and management of patients with spinal cord injuries and guidance on the appropriate methods of treatment. It also highlights the growing role of anesthetists as vital members of the medical teams in accident and emergency and trauma units, in the intensive care environment and in the relief of pain. This book is organized into 13 chapters. The first two chapters deal with the pathophysiology and initial care for spinal cord injury patients. The succeeding chapters discuss the emergency room care, anesthetic management, intensive care management, chronic care, and nursing care for spinal cord injuries. The final two chapters are about trend in spinal cord injury research and the legal and moral issues associated with the treatments of spinal cord injuries. This book will be of interest to anesthetists and other medical professionals dealing with spinal cord injuries.

Pain Following Spinal Cord Injury

Pain Following Spinal Cord Injury
Author: Petra Eva Dokladal
Publsiher: Unknown
Total Pages: 214
Release: 2009
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Pain Following Spinal Cord Injury Book Excerpt:

Mechanisms for Chronic Pain After Spinal Cord Injury

Mechanisms for Chronic Pain After Spinal Cord Injury
Author: Jamie Craig Bruce
Publsiher: Unknown
Total Pages: 218
Release: 2001
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Mechanisms for Chronic Pain After Spinal Cord Injury Book Excerpt:

The Pain That s the Injury the Day to day Living with It

 The Pain  That s the Injury  the Day to day Living with It
Author: Linda Teresa Boutin
Publsiher: Unknown
Total Pages: 135
Release: 2021
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Pain That s the Injury the Day to day Living with It Book Excerpt:

Animal Models of Neuropathic Pain After Spinal Cord Injury

Animal Models of Neuropathic Pain After Spinal Cord Injury
Author: Ahmed M. M. Emraja
Publsiher: Unknown
Total Pages: 275
Release: 2013
ISBN: 1928374650XXX
Category: Neuralgia
Language: EN, FR, DE, ES & NL

Animal Models of Neuropathic Pain After Spinal Cord Injury Book Excerpt:

Approximately 70% of spinal cord injured patients suffer from pain and it is estimated that in 40-50% of these, the pain is of central neuropathic origin. This pain can be perceived to originate at, or below the level of injury and both evoked and spontaneous pain can occur. Neuropathic pain after spinal cord injury (SCI) is difficult to treat and often poorly controlled by the currently available analgesics so that development of better treatments is an important need. Current ideas about the treatment of SCI pain are that different approaches may be needed to treat the different types of pain (e.g. evoked and spontaneous, at level and below level) as they may have different mechanisms. However, this mechanistic approach to treatment is hampered by a poor understanding of the underlying mechanisms. This in turn depends on development of animal models and pain assessment techniques suitable for mechanistic studies. In this thesis, several rodent SCI models have been investigated using a range of assessment techniques some of which were developed in the course of the study. Contusion injuries at a low thoracic level are currently the most popular model used to investigate central neuropathic pain in rodents. However this model and the assessments used with it are subject to a number of limitations. We therefore began by re-evaluating this model using a relatively severe (200 kdyn) injury since this is indicated in the literature as being necessary for the development of robust signs of neuropathic pain. We found that this model showed robust signs of tactile allodynia and thermal hyperalgesia of the forepaws and in addition by developing new tests, were able to demonstrate cold allodynia and hyperalgesia. Although the hindpaws also showed responses that would normally be interpreted as mechanical allodynia and thermal hyperalgesia, the absence of accompanying supraspinally mediated behaviours (including licking following heat stimuli) indicated that the enhanced responsiveness to these stimuli might not give rise to pain. Further investigation using operant testing supported this idea and tract tracing suggested that this may be due to substantial interruption of ascending nociceptive pathways. Testing over the back at locations confirmed electrophysiologically to involve sensory processing at, above and below the injury level supported the idea that increased sensitivity in this model developed at and above, but not below level. In addition, observations on the forepaws suggested evidence of spontaneous pain which has never been described in SCI models previously and provides an important opportunity for studying the underlying mechanisms. Because the 200 kdyn low thoracic model proved unsuitable for the study of below level pain we next investigated whether a less severe injury at this level would provide a better model. Injuries of 150 kdyn were found to result in most of the same indicators of pain following forelimb testing as were seen following 200 kdyn injuries but all signs were less pronounced, in particular, indicators of evoked pain. Testing over the back led to increased sensitivity below level which had not been evident in the 200 kdyn model, providing an opportunity for below level testing. However, interpretation of hindpaw tests remained equivocal. Because the low thoracic model showed features that suggested forelimb assessments were particularly useful for the assessment of above level pain of different modalities as well as spontaneous pain, we investigated the effect of moving the injury closer to the segments assessed by such tests. Injuries at the T3/T4 level were found to lead to enhancement of all of the behavioural signs seen in the 200 kdyn low thoracic injury animals, especially signs of spontaneous pain. This model may therefore be optimum for the assessment of above/at level pain. The work presented in this thesis provides the clearest and most comprehensive data yet on the utility of models of SCI for the investigation of central neuropathic pain and represents a significant advance in the field. The finding that injuries at low thoracic levels may (depending on injury severity) be unsuitable for assessment of below level pain has implications for previous studies of the mechanisms of post SCI pain, many of which have used exclusively hindlimb assessments in these models. The hope is that an improved understanding of the models used here and an improved ability to investigate different modalities of evoked pain, and in addition spontaneous pain, will enhance the quality of future research in this area and lead to both a better understanding of central neuropathic pain mechanisms and the development of more effective analgesics for this type of pain.

Management of Chronic Central Neuropathic Pain Following Traumatic Spinal Cord Injury

Management of Chronic Central Neuropathic Pain Following Traumatic Spinal Cord Injury
Author: Alejandro R. Jadad,United States. Agency for Healthcare Research and Quality,McMaster University. Evidence-based Practice Center
Publsiher: Unknown
Total Pages: 5
Release: 2001
ISBN: 9781587631085
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Management of Chronic Central Neuropathic Pain Following Traumatic Spinal Cord Injury Book Excerpt:

Spinal Cord Injury

Spinal Cord Injury
Author: Institute of Medicine,Board on Neuroscience and Behavioral Health,Committee on Spinal Cord Injury
Publsiher: National Academies Press
Total Pages: 360
Release: 2005-08-27
ISBN: 0309095859
Category: Medical
Language: EN, FR, DE, ES & NL

Spinal Cord Injury Book Excerpt:

An estimated 11,000 spinal cord injuries occur each year in the United States and more than 200,000 Americans suffer from maladies associated with spinal cord injury. This includes paralysis, bowel and bladder dysfunction, sexual dysfunction, respiratory impairment, temperature regulation problems, and chronic pain. During the last two decades, longstanding beliefs about the inability of the adult central nervous system to heal itself have been eroded by the flood of new information from research in the neurosciences and related fields. However, there are still no cures and the challenge of restoring function in the wake of spinal cord injuries remains extremely complex. Spinal Cord Injury examines the future directions for research with the goal to accelerate the development of cures for spinal cord injuries. While many of the recommendations are framed within the context of the specific needs articulated by the New York Spinal Cord Injury Research Board, the Institute of Medicine’s panel of experts looked very broadly at research priorities relating to future directions for the field in general and make recommendations to strengthen and coordinate the existing infrastructure. Funders at federal and state agencies, academic organizations, pharmaceutical and device companies, and non-profit organizations will all find this book to be an essential resource as they examine their opportunities.

Neuropathic pain and spasticity following spinal cord injury

Neuropathic pain and spasticity following spinal cord injury
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2022
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Neuropathic pain and spasticity following spinal cord injury Book Excerpt:

Assessment Of Central Sensitization In Neuropathic Pain Following Spinal Cord Injury

Assessment Of Central Sensitization In Neuropathic Pain Following Spinal Cord Injury
Author: Michu00e8le Hubli
Publsiher: Unknown
Total Pages: 135
Release: 2017
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Assessment Of Central Sensitization In Neuropathic Pain Following Spinal Cord Injury Book Excerpt:

Background aims:Causes of chronic pain are postulated to lie in abnormal pain modulation apparent in many diseases. The nociceptive system is balanced with certain anti- and pro-nociceptive mechanisms. Former includes the spinal inhibitory network assessed by conditioned pain modulation. Latter is due to a sensitization along the nociceptive neuraxis leading to ectopic excitability, contributing to hyperalgesia and allodynia. Temporal summation of pain (TSP) reflects this central sensitization.Methods:This study assesses pain modulation during tonic noxious heat application in three groups: Thoracic spinal cord injury (SCI) patients with and without neuropathic pain (NP), and matched healthy controls. The assessment was performed at the volar forearm in order to investigate a sensory intact area. A thermode was heated to 45u00b0C, and the participant was instructed to rate the pain on a numeric rating scale. Subsequently, they had to keep the pain level constant for two minutes by adjusting the temperature of the thermode (participant-controlled temperature, PCT). Clicking the mouse buttons increased or decreased the temperature, respectively.Results:The binary analysis of TSP occurrence highlighted that NP patients show the highest percentage of TSP occurrences (NP: 88%, nonNP: 63.6%, HC: 80%). Statistical analysis revealed a significant increase of the TSP magnitude and the TSP area under curve between the NP and nonNP SCI group.Conclusions:Increased temporal summation of pain u2013 acting as a proxy for central sensitization - was found in SCI patients with chronic NP. The method of tonic heat profiles enables a continuous measure allowing the analysis of adaptation and the TSP processes.

Central Neuropathic Pain in Mouse Models of Spinal Cord Injury

Central Neuropathic Pain in Mouse Models of Spinal Cord Injury
Author: Timo Albert Nees
Publsiher: Unknown
Total Pages: 135
Release: 2016
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Central Neuropathic Pain in Mouse Models of Spinal Cord Injury Book Excerpt:

Spinal Cord Injury Rehabilitation An Issue of Physical Medicine and Rehabilitation Clinics of North America

Spinal Cord Injury Rehabilitation  An Issue of Physical Medicine and Rehabilitation Clinics of North America
Author: Diana Cardenas
Publsiher: Elsevier Health Sciences
Total Pages: 225
Release: 2014-08-01
ISBN: 0323320236
Category: Medical
Language: EN, FR, DE, ES & NL

Spinal Cord Injury Rehabilitation An Issue of Physical Medicine and Rehabilitation Clinics of North America Book Excerpt:

This issue includes a range of topics in SCI from acute neuroprotection to chronic complications, focusing on some of the technological advances that have informed specific areas.

Central Pain in Spinal Cord Injury

Central Pain in Spinal Cord Injury
Author: Nanna Brix Finnerup
Publsiher: Unknown
Total Pages: 135
Release: 2008
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Central Pain in Spinal Cord Injury Book Excerpt:

Perspectives and experiences of health care professionals regarding pain management after spinal cord injury

Perspectives and experiences of health care professionals regarding pain management after spinal cord injury
Author: Anonim
Publsiher: Unknown
Total Pages: 50
Release: 2015
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Perspectives and experiences of health care professionals regarding pain management after spinal cord injury Book Excerpt: