Stem Cells and Aging

Stem Cells and Aging
Author: Surajit Pathak,Antara Banerjee
Publsiher: Academic Press
Total Pages: 320
Release: 2021-03-17
ISBN: 0128204133
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cells and Aging Book Excerpt:

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Stem Cells and Aging

Stem Cells and Aging
Author: Kursad Turksen
Publsiher: Humana Press
Total Pages: 179
Release: 2013-02-13
ISBN: 9781627033183
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cells and Aging Book Excerpt:

Over time, it has become clear that changes in stem cells do occur during aging, not only in their number but also in their relationship to their microenvironment and their functionality as reflected in changes to their metabolome. Stem Cells and Aging: Methods and Protocols brings together chapters from expert contributors with protocols critical for exploring the biology of stem cell aging, all of which is key for understanding these age-related stem cell changes at a basic biology level and at the level of their impacts for regenerative medicine. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy to use, Stem Cells and Aging: Methods and Protocols serves as an ideal reference to guide investigators toward further valuable answers to the problems of our aging population.

Adult Stem Cells in Aging Diseases and Cancer

Adult Stem Cells in Aging  Diseases and Cancer
Author: K.L. Rudolph
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 88
Release: 2014-12-22
ISBN: 3318027324
Category: Medical
Language: EN, FR, DE, ES & NL

Adult Stem Cells in Aging Diseases and Cancer Book Excerpt:

The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Stem Cell Aging Mechanisms Consequences Rejuvenation

Stem Cell Aging  Mechanisms  Consequences  Rejuvenation
Author: Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian
Publsiher: Springer
Total Pages: 354
Release: 2015-07-06
ISBN: 370911232X
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cell Aging Mechanisms Consequences Rejuvenation Book Excerpt:

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Antiaging Effect of Stem Cells on Aging and Stem Cell Aging

Antiaging   Effect of Stem Cells on Aging and Stem Cell Aging
Author: Jisook Moon
Publsiher: Unknown
Total Pages: 135
Release: 2015
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Antiaging Effect of Stem Cells on Aging and Stem Cell Aging Book Excerpt:

Aging is defined broadly as the normal progressive process, consequently leading to growing vulnerability to disease and death. A major challenge lies in dissecting the underlying mechanisms of aging with conventional experiments due to the complexity of and multicontributions to the aging process, reflecting a need for investigation into it in various aspects. For this reason, the age process has currently been subjected to OMICS technologies including genomics, transcriptomics, proteomics, and metabolomics, allowing the exploration of age-related changes in a multifactorial manner. In addition, since age-dependent decline in stem cell function is almost identical to the biological age, stem cells have used to understand "aging" and to investigate key reverse factors for "antiaging". This suggests that a range of new approaches are needed to reveal the unknown biological basis for aging at a variety of different molecular levels using stem cells as a tool of normal aging process and can further apply fundamental aspects in biological aging and longevity.

Advances in Stem Cell Aging

Advances in Stem Cell Aging
Author: K.L. Rudolph
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 134
Release: 2012-09-27
ISBN: 3318021717
Category: Science
Language: EN, FR, DE, ES & NL

Advances in Stem Cell Aging Book Excerpt:

Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells.This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.

Molecular Mechanisms of Adult Stem Cell Aging

Molecular Mechanisms of Adult Stem Cell Aging
Author: K.L. Rudolph
Publsiher: Karger Medical and Scientific Publishers
Total Pages: 116
Release: 2010-04-22
ISBN: 3805592442
Category: Medical
Language: EN, FR, DE, ES & NL

Molecular Mechanisms of Adult Stem Cell Aging Book Excerpt:

There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field.The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis.Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology.

Aging Stem Cells and the Cancer Stem Cell Hypothesis

Aging  Stem Cells and the Cancer Stem Cell Hypothesis
Author: Dave Comstock,City University of New York. City College
Publsiher: Unknown
Total Pages: 132
Release: 2012
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Aging Stem Cells and the Cancer Stem Cell Hypothesis Book Excerpt:

Telomeres and Telomerase in Aging Disease and Cancer

Telomeres and Telomerase in Aging  Disease  and Cancer
Author: K. Lenhard Rudolph
Publsiher: Springer Science & Business Media
Total Pages: 330
Release: 2007-11-07
ISBN: 354073709X
Category: Medical
Language: EN, FR, DE, ES & NL

Telomeres and Telomerase in Aging Disease and Cancer Book Excerpt:

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Hair Follicle Stem Cell Regeneration in Aging

Hair Follicle Stem Cell Regeneration in Aging
Author: Mingxing Lei,Sung-Jan Lin,Cheng Ming Chuong
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-01-18
ISBN: 2889740625
Category: Science
Language: EN, FR, DE, ES & NL

Hair Follicle Stem Cell Regeneration in Aging Book Excerpt:

The Anti Aging Triad

The Anti Aging Triad
Author: Stephen Holt
Publsiher: AuthorHouse
Total Pages: 320
Release: 2011-04-01
ISBN: 1456755757
Category: Health & Fitness
Language: EN, FR, DE, ES & NL

The Anti Aging Triad Book Excerpt:

Th is book is a ground breaking review of the three most important scientifi c areas of anti-aging medicine. Stephen Holt MD has navigated areas of conventional and integrative medicine to produce a book that is valuable for both a layperson and biomedical experts.

Effects of the Local Organ and Systemic Environments on Stem Cell Aging

Effects of the Local Organ and Systemic Environments on Stem Cell Aging
Author: Morgan Erik Carlson
Publsiher: Unknown
Total Pages: 570
Release: 2008
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Effects of the Local Organ and Systemic Environments on Stem Cell Aging Book Excerpt:

This work uncovers mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans, and affect both embryonic and adult stem cells. Specifically, the effects of aged muscle and systemic niches on key molecular identifiers of regenerative potential of human embryonic stem cells (hESCs) and postnatal muscle stem cells (satellite cells) were examined. Results reveal that aged differentiated niches dominantly inhibit the expression of Oct4 in hESC and Myf-5 in activated satellite cells, and reduce proliferation and myogenic differentiation of both embryonic and tissue specific adult stem cells (ASCs). Therefore, the ability of hESCs, and the more differentiated myogenic ASCs to contribute to tissue repair in the old will be restricted, due to the conserved inhibitory influence of aged differentiated niches. Additionally, this work establishes that hESC-derived factors enhance the regenerative potential of both young and importantly, aged muscle stem cells in vitro and in vivo; thus, suggesting that the regenerative outcome of stem cell-based replacement therapies will be determined by a balance between negative influences of aged tissues on transplanted cells and positive effects of embryonic cells on the endogenous regenerative capacity.

Stem Cells

Stem Cells
Author: Anonim
Publsiher: Unknown
Total Pages: 96
Release: 2013
ISBN: 9789832915010
Category: Aging
Language: EN, FR, DE, ES & NL

Stem Cells Book Excerpt:

Mammalian Development

Mammalian Development
Author: Anonim
Publsiher: Unknown
Total Pages: 138
Release: 1999
ISBN: 1928374650XXX
Category: Mammals
Language: EN, FR, DE, ES & NL

Mammalian Development Book Excerpt:

Centrosomal Sas 6 in Regulation of Stem Cells and Aging

Centrosomal Sas 6 in Regulation of Stem Cells and Aging
Author: Li Ming Gooi
Publsiher: Unknown
Total Pages: 111
Release: 2017
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Centrosomal Sas 6 in Regulation of Stem Cells and Aging Book Excerpt:

Insights Into Stem Cell Aging

Insights Into Stem Cell Aging
Author: A. Herrera-Merchan
Publsiher: Unknown
Total Pages: 135
Release: 2012
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Insights Into Stem Cell Aging Book Excerpt:

Insights Into Stem Cell Aging.

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing
Author: Susie Prof. Nilsson
Publsiher: Academic Press
Total Pages: 258
Release: 2020-08-22
ISBN: 0128220201
Category: Science
Language: EN, FR, DE, ES & NL

The Stem Cell Niche during Ageing Book Excerpt:

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Stem Cell Aging

Stem Cell Aging
Author: Primož Rožman
Publsiher: Unknown
Total Pages: 135
Release: 2018
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cell Aging Book Excerpt:

Stem cells persist throughout life, replacing cells lost to homeostatic turnover, injury, and disease. However, their functions decline with age, which contributes to degeneration and dysfunction. The molecular mechanisms involved in the aging of stem cells are the same as the ones involved in the aging of somatic cells, including telomere shortening, oxidative stress, epigenetic dysregulation, miRNAs changes, alterations of DNA, RNA, proteome, and various cellular organelles. Aging impacts various pathways, such as insulin/insulin-like growth factor 1 (IGF-1), mTOR, FoxO, AMP-activated protein kinase (AMPK), sirtuin, and many others, resulting in senescent stem cells that exhibit functional and numerical impairment. Stem cells have developed special mechanisms to prevent age related damage accumulation and to sustain their stemness properties, however, these mechanisms lose their effectiveness over time. The most fatal consequence of this is found in the immune system, where both innate and adaptive immunity are affected, exhibiting a plethora of defects, including increased autoimmune disease occurrence, elevated tolerance to cancer and chronic inflammatory status. Stem cell therapies call for the best quality of stem cells grafts. Stem cell products should be devoid of cells containing a senescent phenotype, thus a comprehensive knowledge of the biology behind the senescence of stem cells should be taken into account in every cell based therapy.

Stem Cell Aging and Regenerative Medicine

Stem Cell Aging and Regenerative Medicine
Author: Anonim
Publsiher: Unknown
Total Pages: 70
Release: 2008
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Stem Cell Aging and Regenerative Medicine Book Excerpt:

Stem Cells A Cellular Fountain of Youth

Stem Cells  A Cellular Fountain of Youth
Author: M.P. Mattson,G. van Zant
Publsiher: Elsevier
Total Pages: 240
Release: 2002-08-21
ISBN: 9780444507310
Category: Medical
Language: EN, FR, DE, ES & NL

Stem Cells A Cellular Fountain of Youth Book Excerpt:

This volume provides a timely and thorough review of the current state of understanding of a fascinating type of cell that is capable of forming many or all cells in the body. In humans and other mammals embryonic stem cells, the immediate offspring of the fertilized egg, are capable of forming any type of cell in the body. Moreover stem cells are present in many different tissues in adults that are capable of dividing and differentiating into the specific cell types that comprise the organ in which they reside. A major focus of the book is to provide the reader with up-to-date information on the molecular mechanisms that regulate the proliferation, differentiation and survival of stem cells, and how aging and age-related disease impacts on stem cells. Leading authorities detail the properties and therapeutic potential of embryonic stem cells and stem cells of the nervous and immune systems, muscle and bone. Particularly exciting are emerging technologies for using stem cells to treat human age-related diseases including cardiovascular disease, diabetes, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. This book will be a valuable reference for developmental biologists and for scientists and clinicians who study and treat a variety of diseases.