Stress Depression Inflammation and Personalized Medicine

Stress  Depression  Inflammation  and Personalized Medicine
Author: Pharm Tao
Publsiher: Lulu Press, Inc
Total Pages: 135
Release: 2016-08-31
ISBN: 1329905768
Category: Science
Language: EN, FR, DE, ES & NL

Stress Depression Inflammation and Personalized Medicine Book Excerpt:

Psychological stress has been associated with higher levels of inflammation and the risks of many physical disorders including heart diseases. Inflammatory processes are the common complications of a wide range of diseases including diabetes and cancer. Inflammation can be enhanced by stress and depression, such as in the condition of troubled relationships. The emerging field of psychoneuroimmunology (PNI) focuses on the interactions among the immune system, the central nervous system (CNS), and behavior. Both genetic and environmental factors can influence human personality and various mental problems including autism, bipolar disorder, schizophrenia, and post-traumatic stress disorder (PTSD). Gene-environment interactions may affect neural processing and play a critical role in individual differences in disease susceptibility. The identification of these factors can help with the development of strategies for more targeted care in personalized medicine.

The immunology of cellular stress proteins

The immunology of cellular stress proteins
Author: Willem Van Eden,Ruurd Van Der Zee,Cristina Bonorino
Publsiher: Frontiers E-books
Total Pages: 135
Release: 2014-10-05
ISBN: 288919325X
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The immunology of cellular stress proteins Book Excerpt:

Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins started to comprise a widening spectrum of topics with potential medical relevance. Interestingly, since stress proteins have their activities in both innate and adaptive immunity, they are key elements in the cross-roads between both arms of the immune system. Stress proteins or HSP can be considered as functional 'biomarkers' of inflammation. They are up-regulated locally during inflammation and interestingly, they seem to function as targets for anti-inflammatory regulatory T cells. In experimental models of autoimmunity, mainly arthritis, administration of HSP peptides have been shown to suppress disease. First clinical trials have shown the anti-inflammatory nature of T cell responses to Hsp. In type I diabetes and in rheumatoid arthritis, parenteral and oral administration of Hsp peptides were shown to induce a bias in pro-inflammatory T cells, switching them in the direction of regulatory cytokine production (IL4, IL5 and IL10). In addition a raised level of a marker of natural T regulatory cells, the transcription factor FoxP3, was noted in the RA trial. Other inflammatory diseases or diseases with inflammatory components which feature the immune imprint of the up-regulated Hsp are atherosclerosis, inflammatory bowel diseases, multiple sclerosis and atopic diseases such atopic dermatitis and allergic asthma.

Cytokines

Cytokines
Author: Robert E. Faith,Anthony J. Murgo,Robert A. Good,Nicholas P. Plotnikoff
Publsiher: CRC Press
Total Pages: 405
Release: 2006-10-10
ISBN: 1420003801
Category: Medical
Language: EN, FR, DE, ES & NL

Cytokines Book Excerpt:

Cytokine involvement in the immune system's response to stress is now very well documented. Cytokine activity has been implicated in a variety of mental and physical diseases, and has been shown to have a significant role in fueling the vicious circle of depression and illness. The first edition of Cytokines: Stress and Immunity pointed out

The Psychoneuroimmunology of Chronic Disease

The Psychoneuroimmunology of Chronic Disease
Author: Kathleen Kendall-tackett,Kathleen A. Kendall-Tackett
Publsiher: Amer Psychological Assn
Total Pages: 263
Release: 2010
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

The Psychoneuroimmunology of Chronic Disease Book Excerpt:

Recent years have witnessed considerable growth in the field of psychoneuroimmunology (PNI), which describes how psychological factors, such as stress and depression, impact the neurological and immune systems. Research increasingly indicates that psychological states play a key role in the development and exacerbation of inflammatory diseases such as heart disease, diabetes, multiple sclerosis, Alzheimers, and autoimmune disorders. In this book, editor Kathleen Kendall-Tackett and an elite group of researchers explore the ways physical and psychological stressors such as poor sleep, PTSD, and depression, trigger the inflammatory response and increase the risk of disease. They approach this material from a variety of perspectives. Chapters in Part I describe the biological processes involved in inflammation, focusing on both the typical bodily response to threat as well as on the long-term deleterious effects of stress upon the immune system; while chapters in Part II examine the role of psychosocial stress in disease etiology. Throughout, chapter authors present evidence of connections between mind and body, and emphasize the need for improved communication between physicians and mental health care providers. This book will be a valuable resource for researchers as well as practitioners who hope to share the benefits of these findings with their clients.

Stress Science

Stress Science
Author: George Fink
Publsiher: Unknown
Total Pages: 795
Release: 2010
ISBN: 9780123750662
Category: Medical
Language: EN, FR, DE, ES & NL

Stress Science Book Excerpt:

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that explains the phenomenon of stress, the neural, endocrine and molecular mechanisms involved, the clinical effects, and the impact on individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing's Syndrome: Addison's Disease) and the adverse impact of stress on human physical and mental health . Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is also placed on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries. Chapters offer impressive scope with topics addressing animal studies, disaster, diurnal rhythms, drug effects and treatments, cognition and emotion, physical illness, psychopathology, immunology and inflammation, lab studies and tests, and psychological / biochemical / genetic aspects Richly illustrated with over 200 figures, 75 in color Priced affordably, this compendium of articles appeals to the end user interested in stress research who would not otherwise purchase the larger Encyclopedia of Stress Articles carefully selected by one of the world's most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge

Inflammation Early Life Stress and Cooperation

Inflammation  Early Life Stress  and Cooperation
Author: Jeffrey Gassen
Publsiher: Unknown
Total Pages: 87
Release: 2020
ISBN: 1928374650XXX
Category: Cooperation
Language: EN, FR, DE, ES & NL

Inflammation Early Life Stress and Cooperation Book Excerpt:

In the current research, I combined insights from the evolutionary sciences, experimental economics, and psychoneuroimmunology to examine the relationship between inflammation and cooperation at the individual, group, and population levels. I hypothesized that cooperation would decrease in the context of heightened inflammation because inflammation delineates a bodily context in which an individual's immediate resource needs are relatively high and the likelihood of realizing returns on investment in building social capital is diminished. Further - because previous research finds that early life stress increases sensitivity to the psychological and behavioral sequelae of inflammation - I predicted that the impact of inflammation on cooperation would be greatest for those from more stressful early life environments. Consistent with these predictions, Studies 1-2 both found that for individuals reporting a lower childhood socioeconomic status (SES) - a proxy measure of early life stress exposure - higher inflammation predicted less cooperation. These differences were not found for those reporting a higher childhood SES. Additionally, Study 2 also found that groups with higher collective levels of inflammation cooperated less, regardless of collective exposure to early life stress. Finally, the results of Study 3 revealed that countries with higher infectious disease prevalence - an environmental context that is linked to elevated inflammatory activity - invested less in public goods and were less sociopolitically stable than countries with lower infectious disease burden. Together, these results provide evidence for the immune system playing a role in regulating cooperative behavior, which may have broader implications for social cohesion and the distribution of public goods.

Inflammation and Immunity in Depression

Inflammation and Immunity in Depression
Author: Bernhard Baune
Publsiher: Academic Press
Total Pages: 636
Release: 2018-05-23
ISBN: 0128110740
Category: Medical
Language: EN, FR, DE, ES & NL

Inflammation and Immunity in Depression Book Excerpt:

Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions

Stress Consequences

Stress Consequences
Author: George Fink
Publsiher: Academic Press
Total Pages: 780
Release: 2010-04-06
ISBN: 9780123751751
Category: Psychology
Language: EN, FR, DE, ES & NL

Stress Consequences Book Excerpt:

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that focuses on the physical and psychological consequences of stress for individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing’s Syndrome: Addison’s Disease) and the adverse impact of stress on human physical and mental health. Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is also placed on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries. Chapters offer impressive scope with topics addressing animal studies, disaster, diurnal rhythms, drug effects and treatments, cognition and emotion, physical illness, psychopathology, immunology and inflammation, lab studies and tests, and psychological / biochemical / genetic aspects Richly illustrated in full color with over 200 figures Articles carefully selected by one of the world’s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge

The Inflamed Feeling

The Inflamed Feeling
Author: Mats Lekander
Publsiher: Oxford University Press
Total Pages: 256
Release: 2021-12-23
ISBN: 0192608649
Category: Psychology
Language: EN, FR, DE, ES & NL

The Inflamed Feeling Book Excerpt:

What do feeling sick and being afraid of strangers have in common? The answer is that these feelings represent a behavioural drive which evolved in our ancestors to combat the most dangerous threat to survival: infection. Behaviour and emotions play pivotal roles in the struggle for good health. When your body is telling your brain that you are sick, you are experiencing survival strategies that developed years ago. Listening to these feelings will allow you to save energy that can be used for recuperation and recovery. Urges of staying still, noticing pain, feeling sorry for yourself, and focusing inward are bodily messages that benefit immune defence. For our forefathers, in whom these strategies evolved, it wasn't enough to change behaviour once sick. Defensive behaviours to be able to avoid infection in the first place were also needed. Thus, tools for detecting illness in others evolved. This is why superficial signs of ill-health, or maybe even the prejudicial idea of a person with a foreign bacterial culture, can cause anxiety and avoidance. Not surprisingly, having a too high or too low sensitivity to inner or outer disease signals is connected to mental as well as somatic disorders. In this book, Mats Lekander explains the science behind perceived health, using Barbie dolls, visual illusions, personal experiences, placebo, hypochondriacs and historical anecdotes. Placed against a back-drop of the latest neuroscience and psychoneuroimmunology he explains why you feel healthy or sick. He describes when he poisoned himself at work and enjoyed it, and why white blood cells and inflammation are key players when our brains trys to guess what is going in our inner worlds. The result is an absorbing and eye-opening book, one that seems so relevant in the current times

Neuroinflammation and Behaviour

Neuroinflammation and Behaviour
Author: Luba Sominsky,Adam K. Walker,Deborah M. Hodgson
Publsiher: Frontiers Media SA
Total Pages: 181
Release: 2015-07-21
ISBN: 288919602X
Category: Electronic book
Language: EN, FR, DE, ES & NL

Neuroinflammation and Behaviour Book Excerpt:

The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will contribute to the development of novel and effective treatment strategies for both the disease and its neurological side effects. In this research topic we explored the relationship between the immune system and the brain throughout life. We include both original research and review papers from animal, clinical and molecular perspectives.

Mind over Matter Regulation of Peripheral Inflammation by the CNS

Mind over Matter   Regulation of Peripheral Inflammation by the CNS
Author: Michael Schäfer,Christoph Stein
Publsiher: Springer
Total Pages: 206
Release: 2012-12-06
ISBN: 3034880391
Category: Medical
Language: EN, FR, DE, ES & NL

Mind over Matter Regulation of Peripheral Inflammation by the CNS Book Excerpt:

Several new developments in the field of neuroimmunology with focus on the brain-to-immune system communication have been the incentive for this PIR volume. It covers topics such as brain-immune interactions, the impact of stress on the immune response, pain and immunosuppression, the modulation of inflammation and pain by the sympathetic nervous system, consequences of nerve injury for the immune system, neuronal mechanisms of immune cell recruitment, and the modulation of the immune response by corticotropin-releasing hormone or adenosine. The authors are a unique group of scientists who are all interested in brain-to-immune interactions; however, each from a different perspective. The volume will serve both neurobiologists and immunologists to understand the influence of the central nervous system on peripheral inflammation. Many aspects of this book will also be stimulating for researchers in the pain field.

Inflammation Aging and Oxidative Stress

Inflammation  Aging  and Oxidative Stress
Author: Stephen C. Bondy,Arezoo Campbell
Publsiher: Springer
Total Pages: 405
Release: 2016-12-14
ISBN: 3319334867
Category: Science
Language: EN, FR, DE, ES & NL

Inflammation Aging and Oxidative Stress Book Excerpt:

The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Related Diseases, and Retardation of Cellular Aging. Inflammation, Oxidative Stress and Age-Related Disease draws from a variety of international perspectives and provides a comprehensive overview of the relationship between disease, cell aging, and oxidative stress, as well as potential for preventing or slowing these processes. This installment of Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice is ideal for researchers, clinicians, and advanced graduate students in the fields of cardiology, neuroscience, biogerontolgy, and cell biology.

Psychoneuroimmunology

Psychoneuroimmunology
Author: Qing Yan
Publsiher: Springer
Total Pages: 136
Release: 2016-10-03
ISBN: 3319451111
Category: Medical
Language: EN, FR, DE, ES & NL

Psychoneuroimmunology Book Excerpt:

This book provides a comprehensive overview of the cutting-edge discoveries and the systems approaches related to the multi-disciplinary field of psychoneuroimmunology (PNI), which may provide the scientific basis for mind-body relationships, and aid in the development of personalized medicine. Specifically, the book focuses on the systems biology studies of complex mechanisms, such as stress and inflammation. There is strong evidence supporting the close relationship between stress, inflammation, and disorders including obesity, cardiovascular disease, diabetes, skin diseases, and sleep disorders. As inflammation is a critical connection among different diseases, further elucidating this connection may contribute to the findings of systemic therapeutic targets. Translational medicine is also addressed, by applying PNI approaches in clinical practice. A major challenge in current bioscience is the translation of basic scientific discoveries into better clinical outcomes. With the understanding of the translational implications of PNI, integrative interventions can be applied to modulate stress responses and to promote healthier behaviors. As an important feature of this book, a broad overview of the PNI-associated integrative interventions is provided. These interventions include nutritional supplements, meditation, and other mind-body strategies. From basic concepts to systems methodologies, from theoretical sources to clinical applications, Psychoneuroimmunology contributes to the understanding and development of PNI toward the establishment of personalized and mind-body medicine.

The Psychoneuroimmunology of Chronic Disease

The Psychoneuroimmunology of Chronic Disease
Author: Kathleen A. Kendall-Tackett
Publsiher: Unknown
Total Pages: 263
Release: 2010
ISBN: 1928374650XXX
Category: Chronic diseases
Language: EN, FR, DE, ES & NL

The Psychoneuroimmunology of Chronic Disease Book Excerpt:

"Why are depressed people more likely to suffer heart attacks? Why do people with hostile worldviews have higher rates of metabolic syndrome and Type 2 diabetes? Recent years have witnessed considerable growth in the field of psychoneuroimmunology, which describes how psychological factors, such as stress and depression, impact the neurological and immune systems. Research increasingly indicates that psychological states play a key role in the development and exacerbation of inflammatory diseases such as heart disease, diabetes, multiple sclerosis, Alzheimer's, and autoimmune disorders. In this book, Kathleen Kendall-Tackett and an elite group of researchers explore the ways physical and psychological stressors such as posttraumatic stress disorder, depression, and poor sleep trigger the inflammatory response and increase the risk of disease. They attack these issues in a variety of ways: Chapters in Part I describe the biological processes involved in inflammation, focusing on both the typical bodily response to threat as well as on the long-term deleterious effects of stress upon the immune system, and chapters in Part I I examine the role of psychosocial stress in disease etiology. Throughout, chapter authors present evidence of connections between mind and body and emphasize the need for improved communication between physicians and mental health care providers. This book will be a valuable resource for researchers as well as practitioners who hope to share the benefits of these findings with their clients"--Jaquette. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging
Author: M. A. Hayat
Publsiher: Academic Press
Total Pages: 338
Release: 2014-09-26
ISBN: 0128010541
Category: Medical
Language: EN, FR, DE, ES & NL

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Book Excerpt:

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood. This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series

The Inflamed Mind

The Inflamed Mind
Author: Edward Bullmore
Publsiher: Picador
Total Pages: 256
Release: 2018-12-31
ISBN: 1250318157
Category: Psychology
Language: EN, FR, DE, ES & NL

The Inflamed Mind Book Excerpt:

As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge profressor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.

Immunity and Inflammation in Health and Disease

Immunity and Inflammation in Health and Disease
Author: Shampa Chatterjee,Wolfgang Jungraithmayr,Debasis Bagchi
Publsiher: Academic Press
Total Pages: 476
Release: 2017-08-31
ISBN: 0128054026
Category: Medical
Language: EN, FR, DE, ES & NL

Immunity and Inflammation in Health and Disease Book Excerpt:

Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. Conceptualizes the key features in natural products which can boost immune function and immune health Explains the intricate mechanistic aspects and balance behind immune health Presents the pathophysiology of several diseases associated with immune system disruption

Immuno Psychiatry

Immuno Psychiatry
Author: Michael Berk,Marion Leboyer,Iris E. Sommer
Publsiher: Springer Nature
Total Pages: 444
Release: 2021-08-14
ISBN: 303071229X
Category: Medical
Language: EN, FR, DE, ES & NL

Immuno Psychiatry Book Excerpt:

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging
Author: M. A. Hayat
Publsiher: Academic Press
Total Pages: 430
Release: 2016-04-08
ISBN: 012802951X
Category: Medical
Language: EN, FR, DE, ES & NL

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Book Excerpt:

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 9: Human Diseases and Autophagosome offers a valuable guide to both cellular processes while helping researchers explore their potentially important connections. Volume 9 emphasizes the role of autophagy in diseases, such as leukemia, antifungal and antibacterial immunity, and transplantation. This volume also explains, in detail, the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of omegasomes to autophagosomes. This information is important because one of the major functions of autophagy is to degrade and eliminate excessive, old, and harmful materials from the cell. Autophagosomes receive these materials (cellular cargo) and transport them to lysosomes for degradation. Lysosomes contain the digestive enzymes (hydrolases) that breakdown proteins, lipids, carbohydrates, etc. (self-digestion). To further explain this phenomenon, the role of the endoplasmic reticulum (ER) in the formation of autophagosomes is discussed. ULK1 and Beclin 1 proteins are also important in the initial formation of autophagosomes, and are also discussed. Because much of the early research in this area was carried out using yeast cells, the role of Golgi complex in the autophagosome formation in these cells is explained. This volume also includes an explanation of the role of the autophagy-related gene ATG5 in cancer (e.g., gastrointestinal cancer). Paradoxically, autophagy is a “double-edged sword because it eliminates some pathogens, whereas it can be used by some intracellular pathogens to multiply and cause infection. This book is an asset to newcomers, providing a concise overview of the role of autophagy in necrosis and inflammation, while also serving as an excellent reference for more experienced scientists and clinicians. Presents the most advanced information regarding the role of the autophagic system in life and death emphasizes autophagy in diseases, such as leukemia Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Edited work with chapters authored by leaders in the field from around the globe—the broadest, most expert coverage available

Heat Shock Proteins Potent Mediators of Inflammation and Immunity

Heat Shock Proteins  Potent Mediators of Inflammation and Immunity
Author: Alexzander A.A. Asea,Antonio De Maio
Publsiher: Springer Science & Business Media
Total Pages: 357
Release: 2007-09-05
ISBN: 1402055854
Category: Medical
Language: EN, FR, DE, ES & NL

Heat Shock Proteins Potent Mediators of Inflammation and Immunity Book Excerpt:

This book provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts’ immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step-wise fashion take the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provide answers as to its biological significance to the host.