System Vaccinology

System Vaccinology
Author: Vijay Kumar Prajapati
Publsiher: Academic Press
Total Pages: 438
Release: 2022-08-26
ISBN: 032389786X
Category: Medical
Language: EN, FR, DE, ES & NL

System Vaccinology Book Excerpt:

Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters. Provides in-depth knowledge of vaccine history Covers the development of system vaccinology and their applications revolutionize the vaccine discovery Gives insights to the development of new strategies to design efficacious and safe vaccine molecule Provides a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials Highlights the importance of differential miRNA expression, microbiome after vaccination for human health Serves the need of students and researcher for applying computational tools and quick designing of potential molecule which may be proposed for vaccine trial Take the decisions to perform the kind of experiments for assessment of vaccine immunogenicity Aims to understand disease pathogenesis and host responses to infection and vaccination Offers a seamless continuum of scientific discovery and vaccine invention

System Vaccinology

System Vaccinology
Author: Vijay Kumar Prajapati
Publsiher: Elsevier
Total Pages: 436
Release: 2022-08-15
ISBN: 0323859410
Category: Medical
Language: EN, FR, DE, ES & NL

System Vaccinology Book Excerpt:

Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters. Provides in-depth knowledge of vaccine history Covers the development of system vaccinology and their applications revolutionize the vaccine discovery Gives insights to the development of new strategies to design efficacious and safe vaccine molecule Provides a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials Highlights the importance of differential miRNA expression, microbiome after vaccination for human health Serves the need of students and researcher for applying computational tools and quick designing of potential molecule which may be proposed for vaccine trial Take the decisions to perform the kind of experiments for assessment of vaccine immunogenicity Aims to understand disease pathogenesis and host responses to infection and vaccination Offers a seamless continuum of scientific discovery and vaccine invention

Computational Systems Biology

Computational Systems Biology
Author: Andres Kriete,Roland Eils
Publsiher: Academic Press
Total Pages: 548
Release: 2013-11-26
ISBN: 0124059384
Category: Computers
Language: EN, FR, DE, ES & NL

Computational Systems Biology Book Excerpt:

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

Current Challenges in Vaccinology

Current Challenges in Vaccinology
Author: Ursula Wiedermann,Rita Carsetti,Ed C. Lavelle,Winfried F. Pickl
Publsiher: Frontiers Media SA
Total Pages: 353
Release: 2021-02-22
ISBN: 2889664538
Category: Medical
Language: EN, FR, DE, ES & NL

Current Challenges in Vaccinology Book Excerpt:

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS).

Recent Advances in Precision Vaccine Discovery Development

Recent Advances in Precision Vaccine Discovery   Development
Author: Ofer Levy,Simon Daniel Van Haren,Scott James Tebbutt,Francesco Borriello,Jay Evans
Publsiher: Frontiers Media SA
Total Pages: 335
Release: 2021-11-23
ISBN: 2889716589
Category: Medical
Language: EN, FR, DE, ES & NL

Recent Advances in Precision Vaccine Discovery Development Book Excerpt:

Topic Editor Jay Evans is the co-founder, President and CEO of Inimmune Corporation. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Systems Biology

Systems Biology
Author: Michael G. Katze
Publsiher: Springer Science & Business Media
Total Pages: 263
Release: 2013-01-04
ISBN: 3642330991
Category: Medical
Language: EN, FR, DE, ES & NL

Systems Biology Book Excerpt:

First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies—oligonucleotide microarrays, mass spectrometry, and next-generation sequencing—and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology.

Healthy Longevity and Immune System

Healthy Longevity and Immune System
Author: Valquiria Bueno,Graham Pawelec
Publsiher: Springer Nature
Total Pages: 208
Release: 2021-11-10
ISBN: 3030875326
Category: Medical
Language: EN, FR, DE, ES & NL

Healthy Longevity and Immune System Book Excerpt:

This book presents studies of the main conditions that affect health and well-being of old people. Considering the present scenario of COVID-19, the effects of this viral infection on individuals older than 65 years are also discussed. The content enables professionals of health and government for the present and future actions in this important area. Readers go through the changes occurring in organs and tissues that can interfere with susceptibility to infections, low response to vaccines, cancer, and loss of cognition during the aging process. A discussion of the central role played by the immune system in the age-related diseases and how the immunity can be impaired during the ageing process is presented. Possibilities to circumvent these conditions via healthy habits in diet, physical exercise, and new pharmacological interventions are part of the content. This book discusses how human healthy longevity is dependent, at least in part, of a functional immune system. Chapters were written for researchers in the field of aging and is especially suited for those interested in the study of immunosenescence and inflammaging affecting the health of old individuals.

Theoretical and Applied Aspects of Systems Biology

Theoretical and Applied Aspects of Systems Biology
Author: Fabricio Alves Barbosa da Silva,Nicolas Carels,Floriano Paes Silva Junior
Publsiher: Springer
Total Pages: 259
Release: 2018-06-21
ISBN: 3319749749
Category: Computers
Language: EN, FR, DE, ES & NL

Theoretical and Applied Aspects of Systems Biology Book Excerpt:

This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases. This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multiresistant bacteria, systems biology of cancer, systems immunology, networks in systems biology.

ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins

ADME and Translational Pharmacokinetics   Pharmacodynamics of Therapeutic Proteins
Author: Honghui Zhou,Frank-Peter Theil
Publsiher: John Wiley & Sons
Total Pages: 472
Release: 2015-10-26
ISBN: 111889880X
Category: Medical
Language: EN, FR, DE, ES & NL

ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins Book Excerpt:

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Computational Systems Biology

Computational Systems Biology
Author: Helder I Nakaya
Publsiher: Elsevier Inc. Chapters
Total Pages: 548
Release: 2013-11-26
ISBN: 0128070161
Category: Medical
Language: EN, FR, DE, ES & NL

Computational Systems Biology Book Excerpt:

Systems Thinking in Medicine and New Drug Discovery

Systems Thinking in Medicine and New Drug Discovery
Author: Robert E. Smith
Publsiher: Cambridge Scholars Publishing
Total Pages: 632
Release: 2018-12-17
ISBN: 1527523667
Category: Medical
Language: EN, FR, DE, ES & NL

Systems Thinking in Medicine and New Drug Discovery Book Excerpt:

Total Quality Management (TQM) and systems thinking are being used to improve all aspects of human health. This first book in a two-volume set details how the healthcare community is working with patients and their caregivers to improve healthcare and reduce its costs. Systems-based thinking encourages us to work together to look at the effects of new drugs on entire systems and not just single molecular targets. It also leads us to a better understanding of genetics and epigenetics, as well as the deep ecology of the human body. The healthcare community is developing targeted therapies that stimulate our own bodies to cure ourselves and eliminate the need for animal testing. This book will appeal to specialists, who will find recommendations on safer materials for 3D bioprinting and ways to analyze dietary supplements for toxic contaminants, and physicians, pharmacists and non-professionals, who will learn the important different ways that dietary supplements and prescription drugs are developed, sold and marketed.

The Aging Immune System and Health

The Aging Immune System and Health
Author: Valquiria Bueno,Rafael Solana,Annemieke Boots
Publsiher: Frontiers Media SA
Total Pages: 314
Release: 2020-01-15
ISBN: 2889633616
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Aging Immune System and Health Book Excerpt:

The world population presents an increased percentage of individuals over 65 years old and the fastest growing subgroup is over 85 years old. The increase in life expectancy observed in the last century has not been synonymous with extra years lived in good health (disability-free years). Population studies have shown that as individuals age, they can present a great heterogeneity of ability and health. Therefore, aging has been associated for some individuals with disabilities and hospitalizations. Deaths related to infectious pathogens are increased in the aging population mainly due to pneumonia and influenza whereas Cytomegalovirus, Epstein-Barr virus, among other viruses seem to contribute to the low-grade inflammatory process observed (inflammaging). Aging is a complex and multifactorial process in which functions of the organism are adjusted (remodelled) in order to deal with damaging events during life. One of the most important changes in aging individuals occurs in the immune system (innate and adaptive responses) with consequences such as poor response to new infections and vaccinations; increased susceptibility to cancer development and autoimmune diseases; frailty, and organ dysfunction. In addition, it has been proposed that immunosenescence not only reflects the aging of the organism but also contributes to this process. Bone marrow presents decreased hematopoiesis, the thymus undergoes involution and lymphoid organs (lymph nodes, spleen) also present reduced functionality. Therefore, cells derived, matured, or residing in these tissues decline in number and function. These changes have been identified in experimental models, in vitro conditions, peripheral blood, and biopsies via biomarkers such as cell phenotype, stimulus-induced proliferation, cytokines and antibodies levels. Telomere length and telomerase activity also decline in bone marrow-derived and peripheral blood cells and have been shown to play a role in immunosenescence. More recently, the investigation of short non-coding RNA molecules (microRNAs; miRNAs) pointed to this system as a possible control of aging-related mechanisms. Data obtained on these markers for aging individuals could lead to the generation of a marker panel for pathology prediction, to indicate interventions, and to evaluate the efficacy of interventions. Interventions such as nutrition supplements, exercise, vaccination (different dose, concentration of antigen, adjuvants) have been proposed to circumvent age-related diseases. Considering the heterogeneity in the aging process, further investigation is vital before the indication of interventions for aging individuals. As the extension of life expectancy is a reality, it is a challenge to understand how the aging population copes with the remodelling of the organism and how interventions could provide longevity in good health.

Mucosal Vaccines

Mucosal Vaccines
Author: David W. Pascual
Publsiher: Academic Press
Total Pages: 940
Release: 2019-10-19
ISBN: 012811925X
Category: Medical
Language: EN, FR, DE, ES & NL

Mucosal Vaccines Book Excerpt:

Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format. Provides the latest views on mucosal vaccines Applies basic and current principles in the field of mucosal immunology and related scientific fields (e.g., microbiology, infectious diseases, systems biology, medicine, dentistry, veterinary medicine and translational research) to the development of new vaccines Links basic, clinical and practical aspects of mucosal vaccines to different infectious diseases Presents user-friendly organization using attractive illustrations

Handbook of Systems Biology

Handbook of Systems Biology
Author: Marian Walhout,Marc Vidal,Job Dekker
Publsiher: Academic Press
Total Pages: 552
Release: 2012-12-31
ISBN: 012385945X
Category: Science
Language: EN, FR, DE, ES & NL

Handbook of Systems Biology Book Excerpt:

This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

The Science and Applications of Synthetic and Systems Biology

The Science and Applications of Synthetic and Systems Biology
Author: Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publsiher: National Academies Press
Total Pages: 570
Release: 2011-12-30
ISBN: 0309219396
Category: Science
Language: EN, FR, DE, ES & NL

The Science and Applications of Synthetic and Systems Biology Book Excerpt:

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Molecular Vaccines against Pathogens in the Post Genomic Era

Molecular Vaccines against Pathogens in the Post Genomic Era
Author: Angel Alejandro Oñate,Alberto Moreno,Yanmin Wan
Publsiher: Frontiers Media SA
Total Pages: 158
Release: 2020-02-27
ISBN: 2889635139
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Molecular Vaccines against Pathogens in the Post Genomic Era Book Excerpt:

Systems and Synthetic Biology

Systems and Synthetic Biology
Author: Vikram Singh,Pawan K. Dhar
Publsiher: Springer
Total Pages: 385
Release: 2014-12-15
ISBN: 9401795142
Category: Science
Language: EN, FR, DE, ES & NL

Systems and Synthetic Biology Book Excerpt:

This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Paul s Fundamental Immunology

Paul s Fundamental Immunology
Author: Martin Flajnik
Publsiher: Lippincott Williams & Wilkins
Total Pages: 1312
Release: 2022-07-19
ISBN: 1975142527
Category: Medical
Language: EN, FR, DE, ES & NL

Paul s Fundamental Immunology Book Excerpt:

Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.

Influenza Pathogenesis and Control Volume II

Influenza Pathogenesis and Control   Volume II
Author: Michael B. A. Oldstone,Richard W. Compans
Publsiher: Springer
Total Pages: 484
Release: 2014-11-06
ISBN: 3319111582
Category: Medical
Language: EN, FR, DE, ES & NL

Influenza Pathogenesis and Control Volume II Book Excerpt:

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.

Drugs Advances in Research and Application 2011 Edition

Drugs  Advances in Research and Application  2011 Edition
Author: Anonim
Publsiher: ScholarlyEditions
Total Pages: 891
Release: 2012-01-09
ISBN: 1464920923
Category: Medical
Language: EN, FR, DE, ES & NL

Drugs Advances in Research and Application 2011 Edition Book Excerpt:

Drugs: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Trials. The editors have built Drugs: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Trials in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Drugs: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.