The Cell Cycle in the Central Nervous System

The Cell Cycle in the Central Nervous System
Author: Damir Janigro
Publsiher: Springer Science & Business Media
Total Pages: 563
Release: 2008-01-23
ISBN: 1597450219
Category: Medical
Language: EN, FR, DE, ES & NL

The Cell Cycle in the Central Nervous System Book Excerpt:

Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.

Stem Cells and CNS Development

Stem Cells and CNS Development
Author: Mahendra S. Rao
Publsiher: Springer Science & Business Media
Total Pages: 370
Release: 2001-02-20
ISBN: 1592591078
Category: Medical
Language: EN, FR, DE, ES & NL

Stem Cells and CNS Development Book Excerpt:

Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. It defines by consensus the classes of stem cells in the nervous system, compares their similarities and differences, discusses the gains made in identifying human homologs of neural stem cells, and describes how these cells are beginning to be used for therapeutic purposes. Comprehensive and cutting-edge, this book provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.

Neural Stem Cells for Brain and Spinal Cord Repair

Neural Stem Cells for Brain and Spinal Cord Repair
Author: Tanja Zigova
Publsiher: Springer Science & Business Media
Total Pages: 434
Release: 2002-11-05
ISBN: 1592592988
Category: Medical
Language: EN, FR, DE, ES & NL

Neural Stem Cells for Brain and Spinal Cord Repair Book Excerpt:

Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.

Neural Development and Stem Cells

Neural Development and Stem Cells
Author: Mahendra S. Rao,Mohan C. Vemuri,Melissa Carpenter
Publsiher: Springer Science & Business Media
Total Pages: 468
Release: 2007-10-28
ISBN: 1592599141
Category: Medical
Language: EN, FR, DE, ES & NL

Neural Development and Stem Cells Book Excerpt:

Developing the second edition of Neural Development and Stem Cells was neces- tated by the rapid increase in our knowledge of the development of the nervous system. It has become increasingly clear that stem cells are a heterogeneous population that changes extensively during development. Perhaps the most important advance in our understanding of stem cell behavior has been the realization that regionalization of stem cells occurs early in development and this bias toward differentiation in phe- types of neurons or cells characteristic of a particular part of the brain appears to persist even after prolonged culture. We have therefore included additional chapters on olf- tory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone–derived neural stem cells. It is also now clear from an analysis of mutants and transgenics where the death or self-renewal pa- way is altered that cell death regulates stem cell number. As a consequence, this second edition includes a separate chapter on cell death that summarizes the important changes in the death pathway that occur as stem cells mature. The existing chapters in the book have also been extensively revised and updated by experts who have generously c- tributed their time and expertise. The chapters have been organized along the lines of our understanding of how the nervous system develops (Fig. 1, on p. vi).

Cortico Subcortical Dynamics in Parkinson s Disease

Cortico Subcortical Dynamics in Parkinson   s Disease
Author: Kuei-Yuan Tseng
Publsiher: Springer Science & Business Media
Total Pages: 316
Release: 2009-04-20
ISBN: 9781603272520
Category: Medical
Language: EN, FR, DE, ES & NL

Cortico Subcortical Dynamics in Parkinson s Disease Book Excerpt:

The striatum is the principal input structure of the basal ganglia. Numerically, the great majority of neurons in the striatum are spiny projection neurons, which produce the inhibitory output of the striatum to the globus pallidum and substantia nigra. The major glutamatergic afferents to the striatum from the cerebral cortex make monosynaptic contact with spiny projection neurons. The dopaminergic afferents from the substantia nigra also synapse directly on the spiny projection neurons. Thus, the spiny projection neurons play a crucial role in the input–output operations of the striatum by integrating glutamatergic cortical inputs with dopaminergic inputs and producing the output to other basal ganglia nuclei. Anatomical observations made nearly 30 years ago suggested that inhibitory interactions among the spiny projection neurons of the striatum are very pr- able. Individual spiny projection neurons produce a local axonal plexus in the spheroidal space occupied by their own dendritic trees [1, 2]. Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [3–5]. In the idealised concept of lateral inhibition, each output neuron makes inhibitory synaptic contact with its neighbours [5]. However, there are physical limitations set by the extent of axonal and dendritic trees, and the number of synaptic sites, which mean that lateral inhibition is limited to a local domain of inhibition.

Brain Tumors

Brain Tumors
Author: Francis Ali-Osman
Publsiher: Springer Science & Business Media
Total Pages: 393
Release: 2007-10-28
ISBN: 1592598439
Category: Medical
Language: EN, FR, DE, ES & NL

Brain Tumors Book Excerpt:

Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.

Genomic Mosaicism in the Human Brain

Genomic Mosaicism in the Human Brain
Author: Jurjen Willem Westra
Publsiher: Unknown
Total Pages: 206
Release: 2008
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Genomic Mosaicism in the Human Brain Book Excerpt:

The human brain is the most complicated and complex organ in the human body, responsible for not only regulating basic physiological processes such as metabolism and sensation, but also higher cognitive functions such as learning and emotion. As with all other organs of the human body, this complexity in function is built upon the framework of interconnected cells, whose individual activity/function is driven by gene transcription and protein expression. Contemporary models on brain function have been based on the static assumption that cells of the central nervous system operate under constant and non-varying genomes (i.e. that all brain cells contain two copies of each autosome and two sex chromosomes). The body of work contained in this dissertation challenges this notion, and describes the inherently mosaic composition individual cells in the human brain at the genomic level. This dissertation describes the experimental tools used to uncover DNA content variation (DCV) in the mouse and human brain, identifies a novel brain region which exhibits one type of DCV (aneuploid mosaicism), clarifies a cell-cycle based neurodegenerative model of Alzheimer's disease, and characterizes DCV in the normal human brain. The importance of DCV for basic neuroscience is underscored by the observation that DCV changes are associated in a region specific manner in neurodegenerative disease, notably Alzheimer's disease.

Cell Therapy Stem Cells and Brain Repair

Cell Therapy  Stem Cells and Brain Repair
Author: Cyndy D. Davis,Paul R. Sanberg
Publsiher: Springer Science & Business Media
Total Pages: 392
Release: 2007-11-09
ISBN: 1597451479
Category: Medical
Language: EN, FR, DE, ES & NL

Cell Therapy Stem Cells and Brain Repair Book Excerpt:

As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson’s disease, Huntington’s disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body’s own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases.

The Role of Modern Neuro oncology in the Treatment of Primary CNS Tumors and Brain and Spinal Metastases

The Role of Modern Neuro oncology in the Treatment of Primary CNS Tumors  and Brain and Spinal Metastases
Author: Marcos Vinicius Calfat Maldaun,Sujit Prabhu,Claudio Tatsui,Luis Souhami
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-07-10
ISBN: 2889638529
Category: Electronic Book
Language: EN, FR, DE, ES & NL

The Role of Modern Neuro oncology in the Treatment of Primary CNS Tumors and Brain and Spinal Metastases Book Excerpt:

Update on Translational Neuroimmunology Research of ISNI 2018

Update on Translational Neuroimmunology   Research of ISNI 2018
Author: Sandra Amor,Fabienne Brilot,David Brown,Judith M. Greer,Marc J. Ruitenberg
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2020-12-29
ISBN: 2889662950
Category: Medical
Language: EN, FR, DE, ES & NL

Update on Translational Neuroimmunology Research of ISNI 2018 Book Excerpt:

The 14th International Congress of Neuroimmunology, ISNI 2018, was held in August 2018 in Brisbane, Australia, and is a biennial event organized by the International Society of Neuroimmunology (ISNI). The theme of ISNI 2018 was “Travelling the Neuroimmunological Translational Highway”, and the Congress highlighted many research discoveries that bridge the gap between basic and clinical sciences, and which impact our understanding of pathogenic immune-mediated mechanisms in diseases affecting the nervous system. In this Research Topic, we aim to give a comprehensive overview of topics highlighted at the Congress, showcasing the current state of the field of neuroimmunology and where it is going in the near future.

Cell Cycle and Cell Differentiation

Cell Cycle and Cell Differentiation
Author: J. Reinert,H. Holtzer
Publsiher: Springer Science & Business Media
Total Pages: 331
Release: 2013-06-29
ISBN: 354037390X
Category: Science
Language: EN, FR, DE, ES & NL

Cell Cycle and Cell Differentiation Book Excerpt:

It is instructive to compare the response of biologists to the two themes that comprise the title of this volume. The concept of the cell cycle-in contra distinction to cell division-is a relatively recent one. Nevertheless biologists of all persuasions appreciate and readily agree on the central problems in this area. Issues ranging from mechanisms that initiate and integrate the synthesis of chro mosomal proteins and DNA during S-phase of mitosis to the manner in which assembly of microtubules and their interactions lead to the segregation of metaphase chromosomes are readily followed by botanists and zoologists, as well as by cell and molecular biologists. These problems are crisp and well-defined. The current state of "cell differentiation" stands in sharp contrast. This, one of the oldest problems in experimental biology, almost defies definition today. The difficulties arise not only from a lack of pertinent information on the regulatory mechanisms, but also from conflicting basic concepts in this field. One of the ways in which this situation might be improved would be to find a broader experimental basis, including a better understanding of the relationship between the cell cycle and cell differentiation.

Textbook of Contemporary Neurosurgery Volumes 1 2

Textbook of Contemporary Neurosurgery  Volumes 1   2
Author: Vincent A Thamburaj
Publsiher: JP Medical Ltd
Total Pages: 2665
Release: 2012-08-31
ISBN: 9350252392
Category: Medical
Language: EN, FR, DE, ES & NL

Textbook of Contemporary Neurosurgery Volumes 1 2 Book Excerpt:

This two volume set is a comprehensive guide to neurosurgery. Each section covers neurological disorders in different parts of the body, beginning with an introduction and ending with key practice points for quick review, integrating theory and practice. Genetics, ethics and physiotherapy are also discussed. With contributions from recognised specialists in the USA and Europe, this practical manual includes more than 1000 images and illustrations to assist learning and understanding. Key Features Comprehensive two volume set giving complete review of field of neurosurgery Covers numerous neurological disorders in different parts of the body Each section feature key practice points for quick review Integrates theory and practice More than 1000 images and illustrations Contributions from US and European specialists

Cumulated Index Medicus

Cumulated Index Medicus
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1999
ISBN: 1928374650XXX
Category: Medicine
Language: EN, FR, DE, ES & NL

Cumulated Index Medicus Book Excerpt:

Contributions to Contemporary Neurology

Contributions to Contemporary Neurology
Author: Robert B. Daroff,John P. Conomy
Publsiher: Butterworth-Heinemann
Total Pages: 278
Release: 2013-10-22
ISBN: 1483192628
Category: Health & Fitness
Language: EN, FR, DE, ES & NL

Contributions to Contemporary Neurology Book Excerpt:

Contributions to Contemporary Neurology features articles presented at the scientific meeting at the March 1986 gala evening affair held in Cleveland, Ohio in honor of neurologist Joseph Michael Foley's seventieth birthday and his impending transition to Professor Emeritus at Case Western University. This book is organized into 20 chapters written by 41 contributors. It starts with the biography of Foley and ends with his curriculum vitae. In between the biographies and curriculum vitae are basic and clinical articles written by professionals closely associated with Foley throughout his illustrious career. This book will be of interest to those interested in learning about the life and career of neurologist Joseph Michael Foley.

Central Nervous System Metastases

Central Nervous System Metastases
Author: Rohan Ramakrishna,Rajiv S. Magge,Ali A. Baaj,Jonathan P.S. Knisely
Publsiher: Springer Nature
Total Pages: 734
Release: 2020-05-27
ISBN: 303042958X
Category: Medical
Language: EN, FR, DE, ES & NL

Central Nervous System Metastases Book Excerpt:

This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy. Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine.

Stem Cell Research

Stem Cell Research
Author: Janet T. Arnes
Publsiher: Nova Novinka
Total Pages: 199
Release: 2006
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cell Research Book Excerpt:

Embryonic stem cells have the ability to develop into virtually any cell in the body, and may have the potential to treat medical conditions such as diabetes and Parkinson's disease. In August 2001, President Bush announced that for the first time federal funds would be used to support research on human embryonic stem cells, but funding would be limited to 'existing stem cell lines'. The National Institutes of Health (NIH) has established the Human Embryonic Stem Cell Registry which lists stem cell lines that are eligible for use in federally funded research. Although 78 cell lines are listed, 21 embryonic stem cell lines are currently available. Scientists are concerned about the quality, longevity, and availability of the eligible stem cell lines. For a variety of reasons, many believe research advancement requires new embryonic stem cell lines, and for certain applications, stem cells derived from cloned embryos may offer the best hope for progress in understanding and treating disease. A significant cohort of pro-life advocates support stem cell research; those opposed are concerned that the isolation of stem cells requires the destruction of embryos. Letters from Congress, one signed by 206 Members of the House and a second signed by 58 Senators, have been sent urging President Bush to expand the current federal policy concerning embryonic stem cell research. Some have argued that stem cell research be limited to adult stem cells obtained from tissues such as bone marrow. They argue that adult stem cells should be pursued instead of embryonic stem cells because they believe the derivation of stem cells from either embryos or aborted foetuses is ethically unacceptable. Other scientists believe adult stem cells should not be the sole target of research because of important scientific and technical limitations. Groups make ethical distinctions in the debate on how to proceed with stem cell research based upon embryo protection, relief of suffering, viability, the purpose and timing of embryo creation and destruction, donor consent, scientific alternatives, federal funding, and cloning. Other countries are moving fast with active research programs. This book presents the current confused situation along with a selective bibliography.

Metastases to the Central Nervous System An Issue of Neurosurgery Clinics of North America

Metastases to the Central Nervous System  An Issue of Neurosurgery Clinics of North America
Author: Edjah K. Nduom,Jeff Olson
Publsiher: Elsevier Health Sciences
Total Pages: 240
Release: 2020-09-24
ISBN: 0323761933
Category: Medical
Language: EN, FR, DE, ES & NL

Metastases to the Central Nervous System An Issue of Neurosurgery Clinics of North America Book Excerpt:

This issue of Neurosurgery Clinics, guest edited by Drs. Edjah Nduom and Jeff Olson, will focus on Metastases to the Central Nervous System. This issue is one of four selected each year by our series consulting editors, Dr. Russell R. Lonser and Dr. Daniel K. Resnick. Topics discussed in this issue will include: Epidemiology of metastatic CNS disease, Initial approach to the patient with a newly diagnosed solitary brain metastasis, Initial approach to the patient with multiple newly diagnosed brain metastases, When to consider a stereotactic biopsy for brain metastases, Techniques for open surgical resection of cerebral metastases, Laser ablation for cerebral metastases, Histopathological features and laboratory markers of common brain metastases, Recurrence vs radiation necrosis – evaluation and treatment, Anti-epileptic drugs for the management of cerebral metastases, Chemotherapy for the management of cerebral metastases, Approach to the management of metastatic leptomeningeal disease, Immune therapy for CNS metastases, Novel therapeutic targets for the treatment of cerebral metastases, Skull base metastases – diagnosis and management, and more.

Encyclopedia of Neuroscience Volume 1

Encyclopedia of Neuroscience  Volume 1
Author: Larry R. Squire
Publsiher: Academic Press
Total Pages: 12505
Release: 2009-06-12
ISBN: 0080963935
Category: Medical
Language: EN, FR, DE, ES & NL

Encyclopedia of Neuroscience Volume 1 Book Excerpt:

The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.

NIH Almanac

NIH Almanac
Author: National Institutes of Health (U.S.). Division of Public Information
Publsiher: Unknown
Total Pages: 172
Release: 1978
ISBN: 1928374650XXX
Category: Federal aid to medical care research
Language: EN, FR, DE, ES & NL

NIH Almanac Book Excerpt:

American Book Publishing Record

American Book Publishing Record
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2006
ISBN: 1928374650XXX
Category: American literature
Language: EN, FR, DE, ES & NL

American Book Publishing Record Book Excerpt: