The Core Model

The Core Model: A Collaborative Paradigm for the Pharmaceutical Industry and Global Health Care develops the innovative core model, an organizational research and design paradigm and economic theory that proposes a collaborative approach to resolving global health issues and improving the productivity of drug development. The model proposes that scientific collaboration does not occur in an unstructured manner, but actually takes place within a highly structured order where knowledge is transferred, integrated and finally translated into commercial products. An understanding of this model will help solve the global pharmaceutical industry ́s productivity problems and address important global health care and economic issues. This book is useful to researchers, advanced students, regulators, and management in pharmaceutical industries, as well as healthcare professionals, those working in health economics, and those interested in scientific innovation processes. Explores the current state-of-the-art in the pharmaceutical industry and the global healthcare sector Includes insights from world-leading figures in the pharmaceutical industry, healthcare sector, federal funding agencies, regulatory bodies, investment sector, entrepreneurship, intellectual property law, philanthropic organizations, and advocacy groups Develops in-depth, original concepts, which have important implications in the understanding of, and search for, potential solutions to the world ́s health care crisis

The core model, K, is a generalization of Gödel's constructible universe of set theory; K is used to produce 'fine structural' results of a less restrictive kind. This book aims to introduce the core model to those with a basic knowledge of axiomatic set theory. The covering lemma for K is the main technical result but other applications are also considered. The author gives a full exposition of general fine structure and of iterated ultrapowers and concludes the work with a short section on the difficulties encountered in constructing more general core models using 'extenders'.

Since their inception, the Perspectives in Logic and Lecture Notes in Logic series have published seminal works by leading logicians. Many of the original books in the series have been unavailable for years, but they are now in print once again. Large cardinal hypotheses play a central role in modern set theory. One important way to understand such hypotheses is to construct concrete, minimal universes, or 'core models', satisfying them. Since Gödel's pioneering work on the universe of constructible sets, several larger core models satisfying stronger hypotheses have been constructed, and these have proved quite useful. In this volume, the eighth publication in the Lecture Notes in Logic series, Steel extends this theory so that it can produce core models having Woodin cardinals, a large cardinal hypothesis that is the focus of much current research. The book is intended for advanced graduate students and researchers in set theory.

This well-organised, comprehensive reference and textbook describes rate models developed from fundamental kinetic theory and presents models using consistent terminology and notation. Major topics include rate equations, reactor theory, transition state theory, surface reactivity, advective and diffusive transport, aggregation kinetics, nucleation kinetics, and solid-solid transformation rates. The theoretical basis and mathematical derivation of each model is presented in detail and illustrated with worked examples from real-world applications to geochemical problems. The book is also supported by online resources: self-study problems put students' new learning into practice, and spreadsheets provide the full data used in figures and examples, enabling students to manipulate the data for themselves. This is an ideal overview for graduate students, providing a solid understanding of geochemical kinetics. It will also provide researchers and professional geochemists with a valuable reference for solving practical and scientific problems.

This book constitutes the revised selected papers of the combined workshops on Web Information Systems Engineering, WISE 2011 and WISE 2012, held in Sydney, Australia, in October 2011 and in Paphos, Cyprus, in November 2012. The seven workshops of WISE 2011-2012 have reported the recent developments and advances in the contemporary topics in the related fields of: Advanced Reasoning Technology for e-Science (ART 2012), Cloud-Enabled Business Process Management (CeBPM 2012), Engineering in the Semantic Enterprise (ESE 2012), Social Web Analysis for Trend Detection (SoWeTrend 2012), Big Data and Cloud (BDC 2012), Personalization in Cloud and Service Computing (PC-S 2011), and User-Focused Service Engineering, Consumption and Aggregation (USECA 2011).

The book gives an overview of important research topics recently addressed in evolutionary Neo-Schumpeterian Economics. The list of research questions and applications of Neo-Schumpeterian reasoning impressively demonstrates the rich possibilities ranging from theoretical issues addressing human behaviour to applied areas like the emergence of biotechnology in developing countries, the role of innovation on financial markets and the R&D strategies of multinational enterprises. The chapters in this book bring together a rich set of new analytical and empirical methodologies which allow for new relevant and rigorous insights in innovation processes which are responsible for economic development and structural change.​

Biannually since 1994, the European Conference on Product and Process Modelling in the Building and Construction Industry has provided a review of research, given valuable future work outlooks, and provided a communication platform for future co-operative research and development at both European and global levels.This volume, of special interest t

Volume 2 of this series concentrates on the use of synchrotron radiation which covers that region of the electromagnetic spectrum which extends from about 10eV to 3keV in photon energy and is essentially the region where the radiation is strongly absorbed by atmospheric gases. It therefore has to make extensive use of a high vacuum to transport the radiation to the workstation where the presence of hard X-rays can cause extensive damage to both the optics and the targets used in the experimental rigs. The topics chosen for this volume have been limited to the disciplines of physics and chemistry.

The core model, K, is a generalization of Gödel's constructible universe of set theory; K is used to produce 'fine structural' results of a less restrictive kind. This book aims to introduce the core model to those with a basic knowledge of axiomatic set theory. The covering lemma for K is the main technical result but other applications are also considered. The author gives a full exposition of general fine structure and of iterated ultrapowers and concludes the work with a short section on the difficulties encountered in constructing more general core models using 'extenders'.

A compilation of papers presented at the 2001 European Summer Meeting of the Association for Symbolic Logic, Logic Colloquium '01 includes surveys and research articles from some of the world's preeminent logicians. Two long articles are based on tutorials given at the meeting and present accessible expositions of research in two active areas of logic, geometric model theory and descriptive set theory of group actions. The remaining articles cover seperate research topics in many areas of mathematical logic, including applications in Computer Science, Proof Theory, Set Theory, Model Theory, Computability Theory, and aspects of Philosophy. This collection will be of interest not only to specialists in mathematical logic, but also to philosophical logicians, historians of logic, computer scientists, formal linguists and mathematicians in the areas of algebra, abstract analysis and topology. A number of the articles are aimed at non-specialists and serve as good introductions for graduate students.

This periodical edition includes peer-reviewed scientific and engineering papers on all aspects of research in the area of nanoscience and nanotechnologies and wide practical application of the achieved results.

Mathematical Methods in Chemical and Biological Engineering describes basic to moderately advanced mathematical techniques useful for shaping the model-based analysis of chemical and biological engineering systems. Covering an ideal balance of basic mathematical principles and applications to physico-chemical problems, this book presents examples drawn from recent scientific and technical literature on chemical engineering, biological and biomedical engineering, food processing, and a variety of diffusional problems to demonstrate the real-world value of the mathematical methods. Emphasis is placed on the background and physical understanding of the problems to prepare students for future challenging and innovative applications.