The Detection of Biomarkers

The Detection of Biomarkers
Author: Sibel A. Ozkan,Nurgul K. Bakirhan,Fariba Mollaraosouli
Publsiher: Academic Press
Total Pages: 614
Release: 2021-12-05
ISBN: 0128230754
Category: Medical
Language: EN, FR, DE, ES & NL

The Detection of Biomarkers Book Excerpt:

Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. Locates biomarker detection in its research context, setting out present and future prospects Allows clinical researchers to compare various biomarker assays systematically Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical Gives innovative biomarker assays that are viable alternatives to current complex methods Helps clinical researchers who need reliable, precise and accurate biomarker detection methods

Biomarkers in Drug Development

Biomarkers in Drug Development
Author: Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
Publsiher: John Wiley & Sons
Total Pages: 784
Release: 2011-09-20
ISBN: 1118210425
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers in Drug Development Book Excerpt:

Discover how biomarkers can boost the success rate of drugdevelopment efforts As pharmaceutical companies struggle to improve the success rateand cost-effectiveness of the drug development process, biomarkershave emerged as a valuable tool. This book synthesizes and reviewsthe latest efforts to identify, develop, and integrate biomarkersas a key strategy in translational medicine and the drugdevelopment process. Filled with case studies, the bookdemonstrates how biomarkers can improve drug development timelines,lower costs, facilitate better compound selection, reducelate-stage attrition, and open the door to personalizedmedicine. Biomarkers in Drug Development is divided into eightparts: Part One offers an overview of biomarkers and their role in drugdevelopment. Part Two highlights important technologies to help researchersidentify new biomarkers. Part Three examines the characterization and validation processfor both drugs and diagnostics, and provides practical advice onappropriate statistical methods to ensure that biomarkers fulfilltheir intended purpose. Parts Four through Six examine the application of biomarkers indiscovery, preclinical safety assessment, clinical trials, andtranslational medicine. Part Seven focuses on lessons learned and the practical aspectsof implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including dataintegration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or moreleading experts, including scientists from biotechnology andpharmaceutical firms, academia, and the U.S. Food and DrugAdministration. Their contributions offer pharmaceutical andclinical researchers the most up-to-date understanding of thestrategies used for and applications of biomarkers in drugdevelopment.

The Handbook of Biomarkers

The Handbook of Biomarkers
Author: Kewal K. Jain
Publsiher: Humana Press
Total Pages: 760
Release: 2017-09-16
ISBN: 1493974319
Category: Science
Language: EN, FR, DE, ES & NL

The Handbook of Biomarkers Book Excerpt:

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various "-omics" technologies, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers, Second Edition serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important trends in healthcare today.

Developing Affimers for the Detection of Biomarkers in Cancer

Developing Affimers for the Detection of Biomarkers in Cancer
Author: Danah A. A. A. Q. Al-Qallaf
Publsiher: Unknown
Total Pages: 135
Release: 2018
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Developing Affimers for the Detection of Biomarkers in Cancer Book Excerpt:

Principles and Clinical Diagnostic Applications of Surface Enhanced Raman Spectroscopy

Principles and Clinical Diagnostic Applications of Surface Enhanced Raman Spectroscopy
Author: Yuling Wang
Publsiher: Elsevier
Total Pages: 464
Release: 2021-09-17
ISBN: 012823198X
Category: Science
Language: EN, FR, DE, ES & NL

Principles and Clinical Diagnostic Applications of Surface Enhanced Raman Spectroscopy Book Excerpt:

Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy summarizes the principles of surface-enhanced Raman scattering/spectroscopy (SERS) and plasmonic nanomaterials for SERS, with a focus on SERS applications in clinical diagnostics. This book covers the key concepts from the fundamentals, materials, experimental aspects, and applications of SERS in clinical diagnostics with discussions on label-free/direct SERS assay, design and synthesis of SERS nanotags, SERS nanotags for point-of-care diagnostics, microfluidic SERS assay, and in vitro and in vivo sensing and imaging. Written by experts from around the world, this comprehensive volume showcases the recent progress of SERS applications in clinical diagnostics and helps readers understand when and how to use SERS in a clinical setting. Introduces the basics of SERS and suitable nanomaterials for SERS application Gives an overview of the cutting-edge research on SERS applications for clinical diagnosis, including the latest advances in our understanding of underlying principles to enable material design and clinical applications Gradually builds from the fundamental concepts to the applications of SERS for clinical diagnostics

Biomarkers in Cancer Screening and Early Detection

Biomarkers in Cancer Screening and Early Detection
Author: Sudhir Srivastava
Publsiher: John Wiley & Sons
Total Pages: 320
Release: 2017-08-28
ISBN: 1118468805
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers in Cancer Screening and Early Detection Book Excerpt:

Nuts and bolts of biomarker research / Sharmistha Ghosh and Sudhir Srivastava -- Cancer genome methylation : biology, biomarker and therapeutic opportunities / Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi -- Microrna biomarkers for early detection of cancer / Wendy Wang, Matthew R. Young, and Sudhir Srivastava -- Inflammation and cancer / Pamela L. Beatty, Sandra Cascio, and Olivera J Finn -- Exosomes : a valuable biomedical tool in biomarker discovery and development / Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava -- Epithelial-to-mesenchymal transition (EMT) : clinical implications / Elisa CWoodhouse and Suresh Mohla -- Breast cancer / Benjamin A. Katchman, Christos Patriotis, and Karen S Anderson -- Ovarian cancer / Christos Patriotis, Archana Simmons, Karen H. Lu, Robert C. Bast, Jr, and Steven J. Skates -- Esophageal cancer biomarkers / Yanxin Luo, Kishore Guda, Sanford Markowitz, Amitabh Chak, Andrew M Kaz, and William M Grady -- Predictive biomarkers for therapy in adenocarcinoma of the upper digestive tract / Heath D Skinner, Qiongrong Chen, Elena Elimova, Roopma Wadhwa, Shumei Song, and Jaffer A Ajani -- Pancreatic cancer / Sam CWang and Peter J Allen -- Colon cancer / Paul DWagner -- Prognosis and predictive biomarkers for colorectal cancer / Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava -- Early detection of lung cancer / Mohamed Hassanein, Melinda C. Aldrich, Stephen A. Deppen, Karl E. Krueger, Eric L. Grogan, and Pierre P. Massion -- Commonalities in lung cancer and COPD / Malgorzata Wojtowicz and Eva Szabo -- Prostate cancer / Jacob Kagan, Ian M. Thompson, and Daniel W. Chan -- Improving the clinical validity of biomarker research in cancer detection / David F. Ransohoff -- Cancer overdiagnosis, ramifications and research strategies / Barbara K. Dunn and Barnett S. Kramer -- Predictive markers and driver genes from treatment trials : potential utility for early diagnosis / Brian S. Sorg, Sarfraz Memon, Kelly Y. Kim, Aniruddha Ganguly, Tracy Lively, James Tricoli, Magdalena Thurin, Lokesh Agrawal, Tawnya C. McKee, Barbara A. Conley, and J. Milburn Jessup -- Statistical consideration in predictive and prognostic markers / Fei Ye and Yu Shyr -- Clinical validation of molecular biomarkers in translational medicine / Harry B. Burke and William E. Grizzle -- Cancer biomarker assays : performance standards / Anna K Fuzery and Daniel W. Chan -- Bioethics and cancer biomarker research / Nathan Nobis, William Grizzle, and Stephen Sodeke -- Colon cancer screening / Molly Perencevich, Jennifer Inra, and Sapna Syngal

Cancer Biomarkers

Cancer Biomarkers
Author: Debmalya Barh,Angelo Carpi,Mukesh Verma,Mehmet Gunduz
Publsiher: CRC Press
Total Pages: 951
Release: 2014-01-30
ISBN: 1466584297
Category: Medical
Language: EN, FR, DE, ES & NL

Cancer Biomarkers Book Excerpt:

Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin’s lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

Quantitative Multiplex Detection of Biomarkers on a Waveguide based Biosensor Using Quantum Dots

Quantitative Multiplex Detection of Biomarkers on a Waveguide based Biosensor Using Quantum Dots
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2009
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Quantitative Multiplex Detection of Biomarkers on a Waveguide based Biosensor Using Quantum Dots Book Excerpt:

The quantitative, simultaneous detection of multiple biomarkers with high sensitivity and specificity is critical for biomedical diagnostics, drug discovery and biomarker characterization [Wilson 2006, Tok 2006, Straub 2005, Joos 2002, Jani 2000]. Detection systems relying on optical signal transduction are, in general, advantageous because they are fast, portable, inexpensive, sensitive, and have the potential for multiplex detection of analytes of interest. However, conventional immunoassays for the detection of biomarkers, such as the Enzyme Linked Immunosorbant Assays (ELISAs) are semi-quantitative, time consuming and insensitive. ELISA assays are also limited by high non-specific binding, especially when used with complex biological samples such as serum and urine (REF). Organic fluorophores that are commonly used in such applications lack photostability and possess a narrow Stoke's shift that makes simultaneous detection of multiple fluorophores with a single excitation source difficult, thereby restricting their use in multiplex assays. The above limitations with traditional assay platforms have resulted in the increased use of nanotechnology-based tools and techniques in the fields of medical imaging [ref], targeted drug delivery [Caruthers 2007, Liu 2007], and sensing [ref]. One such area of increasing interest is the use of semiconductor quantum dots (QDs) for biomedical research and diagnostics [Gao and Cui 2004, Voura 2004, Michalet 2005, Chan 2002, Jaiswal 2004, Gao 2005, Medintz 2005, So 2006 2006, Wu 2003]. Compared to organic dyes, QDs provide several advantages for use in immunoassay platforms, including broad absorption bands with high extinction coefficients, narrow and symmetric emission bands with high quantum yields, high photostablility, and a large Stokes shift [Michalet 2005, Gu 2002]. These features prompted the use of QDs as probes in biodetection [Michalet 2005, Medintz 2005]. For example, Jaiswal et al. reported long term multiple color imaging of live cells using QD-bioconjugates [Jaiswal 2003]. Gao [Gao 2004] and So [So 2006] have used QDs as probes for in-vivo cancer targeting and imaging. Medintz et al. reported self-assembled QD-based biosensors for detection of analytes based on energy transfer [Medintz 2003]. Others have developed an approach for multiplex optical encoding of biomolecules using QDs [Han 2001]. Immunoassays have also benefited from the advantages of QDs. Recently, dihydrolipoic acid (DHLA) capped-QDs have been attached to antibodies and used as fluorescence reporters in plate-based multiplex immunoassays [Goodman 2004]. However, DHLA-QDs are associated with low quantum efficiency and are unstable at neutral pH. These problems limit the application of this technology to the sensitive detection of biomolecules, especially in complex biological samples. Thus, the development of a rapid, sensitive, quantitative, and specific multiplex platform for the detection of biomarkers in difficult samples remains an elusive target. The goal stated above has applications in many fields including medical diagnostics, biological research, and threat reduction. The current decade alone has seen the development of a need to rapidly and accurately detect potential biological warfare agents. For example, current methods for the detection of anthrax are grossly inadequate for a variety of reasons including long incubation time (5 days from time of exposure to onset of symptoms) and non-specific ('flu-like') symptoms. When five employees of the United State Senate were exposed to B. anthracis in the mail (2001), only one patient had a confirmed diagnosis before death. Since then, sandwich immunoassays using both colorimetric and fluorescence detectors have been developed for key components of the anthrax lethal toxin, namely protective antigen (PA), lethal factor (LF), and the edema factor [Mourez 2001]. While these platforms were successful in assays against anthrax toxins, the sensitivity was poor. Furthermore, no single platform exists for the simultaneous and quantitative detection of multiple components of the B. anthracis toxin. Addressing multiple biomarkers at the same time will increase confidence in a positive result, and may lead to application in the simultaneous detection of anthrax and other biowarfare agents.

Biomarkers and Biosensors

Biomarkers and Biosensors
Author: Ajit Sadana,Neeti Sadana
Publsiher: Newnes
Total Pages: 702
Release: 2014-12-08
ISBN: 0444537953
Category: Science
Language: EN, FR, DE, ES & NL

Biomarkers and Biosensors Book Excerpt:

Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market. Offers thorough coverage of the kinetics of biomarker interaction with the biosensor surface Provides evidence-based approach to evaluate effectiveness Provides pharmaceutical chemists the possibilities and methodology in assessing the effectiveness of new drugs Provides the information needed for the selection of the best biomarker for a specific application

Inflammation and Biomarkers in Osteoarthritis

Inflammation and Biomarkers in Osteoarthritis
Author: Francisco Airton Castro Rocha,João Eurico Fonseca,Ali Mobasheri,Oreste Gualillo,Henrotin Edgard Henrotin,Raquel Largo,Gabriel Herrero-Beaumont
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-09-23
ISBN: 2889713385
Category: Medical
Language: EN, FR, DE, ES & NL

Inflammation and Biomarkers in Osteoarthritis Book Excerpt:

Biomarkers in Urologic Cancer An Issue of Urologic Clinics of North America E Book

Biomarkers in Urologic Cancer  An Issue of Urologic Clinics of North America  E Book
Author: Kevin R. Loughlin
Publsiher: Elsevier Health Sciences
Total Pages: 135
Release: 2016-01-19
ISBN: 0323417191
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers in Urologic Cancer An Issue of Urologic Clinics of North America E Book Book Excerpt:

The past decade has been marked by the acceleration of our understanding of the molecular biology of cancer. Simultaneously, there have been increasing exigencies to diagnose, treat and follow cancer patients more economically. Biomarkers represent the marriage of science and economics. Biomarkers offer the potential to increase the precision of diagnosis, prognosis, and surveillance of urological malignancies. This issue presents the cutting-edge advances of biomarker technology to urologic oncology.

Label Free and Multiplexed Immunosensor Chips for Detection of Macromolecular and Cellular Biomarkers

Label Free and Multiplexed Immunosensor Chips for Detection of Macromolecular and Cellular Biomarkers
Author: Yu Han
Publsiher: Unknown
Total Pages: 123
Release: 2015
ISBN: 1928374650XXX
Category: Biochemical markers
Language: EN, FR, DE, ES & NL

Label Free and Multiplexed Immunosensor Chips for Detection of Macromolecular and Cellular Biomarkers Book Excerpt:

Biomarker detection represents an important task for many scientific fields such as disease diagnosis, biodefense, environmental monitoring and biological research. In this research, micro resistive pulse immunoaggregation sensors were studied to quantitatively detect macromolecular and cellular biomarker concentrations. First, to prove the concept of the immunoaggregation assay and resistive pulse sensing, goat anti-rabbit IgG, used as a model biomarker, was detected by the micro resistive pulse immunoaggregation sensor. A detection range from 16.0 to 160 ng/mL was achieved. The human ferritin in 10% fetal bovine serum was then detected to prove the device's performance in a complex media. A detection range from 0.104 to 208 ng/mL was achieved. In addition, the studies showed that the detection range can be shifted to lower and higher concentrations by decreasing and increasing MP concentrations, respectively. Second, the multiplexed immunoaggregation assay was also studied in this research to achieve multiple biomarker detection in a single test. A mixture consisting of multiple types of MPs functionalized by different antibody with different sizes and magnetic properties was used for testing the multiplexed assay. 2.00 μm non-magnetic MPs coated with rabbit anti-mouse IgG antibody and 2.80 μm magnetic MPs coated with goat anti-human ferritin antibody were used to detect the concentration of mouse anti-rabbit IgG and human ferritin, respectively. Detection ranges from 5.20 to 208 ng/mL and 3.10 to 51.2 × 103 ng/mL were achieved for human ferritin and mouse anti-rabbit IgG detection. Next, a two-stage resistive pulse sensor was invented to detect target cells in a mixed cell population. S. cerevisiae and Chlorella were used as target cells and control cells, respectively. The specific capture efficiency of S. cerevisiae was greater than 94.8%, while the nonspecific capture efficiency was less than 3.4%. S. cerevisiae ratio measurements in a mixture with Chlorella showed that for S. cerevisiae to Chlorella ratios ranging from 1.0 to 2.0, the measurement errors were less than 7%, while the errors were 20% to 32% for lower ratios, ranging from 0.1 to 0.5, caused by nonspecific attachment. The testing results demonstrated that the immunoaggregation biomarker sensor and MP cellular sensor enable reliable detection of target macromolecular and cellular biomarkers in samples at very low concentrations, without the fluorescence and enzyme labeling of biomarker. These innovative biosensors will lead to a fast and cost-effective bioassay instrument for disease diagnosis, environmental monitoring and homeland security.

Immunosensing for Detection of Protein Biomarkers

Immunosensing for Detection of Protein Biomarkers
Author: Huangxian Ju,Guosong Lai,Feng Yan
Publsiher: Elsevier
Total Pages: 304
Release: 2017-05-18
ISBN: 0081020007
Category: Science
Language: EN, FR, DE, ES & NL

Immunosensing for Detection of Protein Biomarkers Book Excerpt:

Immunosensing for Detection of Protein Biomarkers not only introduces the principles, methods, and classification of immunoassay, but also presents the latest achievements in areas such as electrochemical immunosensors, nanoprobe-based immunoassay, chemiluminescence immunoassay, electrochemiluminescent immunoassay, multianalyte immunoassay, optical imaging for immunoassay, signal amplification for immunoassay, and so on. In recent years, immunosensing and immunoassay methods have attracted considerable interest due to their applications in different fields, particularly clinical diagnosis. Although a large number of academic papers in immunosensing and immunoassay have been published in different journals recently, it is still a difficult and time-consuming task for researchers, especially those new to the area, to understand the principles, methods, and research progress of immunosensing. Based on the research experience of the authors and their research groups, this book offers readers with new research ideas to develop immunosensing methodology. As a monograph, it offers deeper and more complete coverage than review papers, which only report certain aspects of progress. Grounded in the research experience of Professor Ju’s research group, the book focuses on immunosensing for detection of protein biomarkers, summarizing understanding, research, and practice on immunosensing methodology in detection of protein biomarkers. Presents the latest research and thinking on immunosensing for detection of protein biomarkers Offers current techniques, and looks to the development of new methodologies Offers the latest developments in various aspects of immunosensing, including electrochemiluminescent immunoassay, multianalyte immunoassay, optical imaging immunoassay, and signal amplification immunoassay Offers readers new ideas to research and develop immunosensing methodologies for the future

Biomarkers Used for the Diagnosis of Diseases

Biomarkers Used for the Diagnosis of Diseases
Author: Satish Balasaheb Nimse,Min Park
Publsiher: Mdpi AG
Total Pages: 118
Release: 2022-03-23
ISBN: 9783036535692
Category: Science
Language: EN, FR, DE, ES & NL

Biomarkers Used for the Diagnosis of Diseases Book Excerpt:

The detection and quantification of with high precision nucleic acid biomarkers and protein biomarkers in resource-limited settings is key to the early diagnosis of diseases and for monitoring the effects of treatments. As there is an enormous demand for high-quality biomarker detection platforms that are robust and highly applicable in resource-limited settings, this book is devoted to exploring methods for detection and quantification of biomarkers, focusing on the recent advances in this field.

Biomarkers of Exposure Effect and Susceptibility to Environmental and Occupational Chemicals

Biomarkers of Exposure  Effect and Susceptibility to Environmental and Occupational Chemicals
Author: Manosij Ghosh,Radu Corneliu Duca
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2021-12-21
ISBN: 2889718344
Category: Science
Language: EN, FR, DE, ES & NL

Biomarkers of Exposure Effect and Susceptibility to Environmental and Occupational Chemicals Book Excerpt:

Development of Ratiometric Nanoprobes and Nanosensors for the Detection of the Hydroxyl Radical Hydrogen Peroxide and Superoxide

Development of Ratiometric Nanoprobes and Nanosensors for the Detection of the Hydroxyl Radical  Hydrogen Peroxide and Superoxide
Author: Matthew Alan King
Publsiher: Unknown
Total Pages: 135
Release: 2005
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Development of Ratiometric Nanoprobes and Nanosensors for the Detection of the Hydroxyl Radical Hydrogen Peroxide and Superoxide Book Excerpt:

Biomarkers in Genitourinary Cancers Volume I

Biomarkers in Genitourinary Cancers  Volume I
Author: Eric A. Singer,Paula Alexandra Quintela Videira,Marco Borghesi
Publsiher: Frontiers Media SA
Total Pages: 226
Release: 2022-05-25
ISBN: 2889762157
Category: Medical
Language: EN, FR, DE, ES & NL

Biomarkers in Genitourinary Cancers Volume I Book Excerpt:

The Handbook of Neuropsychiatric Biomarkers Endophenotypes and Genes

The Handbook of Neuropsychiatric Biomarkers  Endophenotypes and Genes
Author: Michael S. Ritsner
Publsiher: Springer Science & Business Media
Total Pages: 231
Release: 2009-04-24
ISBN: 9048122988
Category: Medical
Language: EN, FR, DE, ES & NL

The Handbook of Neuropsychiatric Biomarkers Endophenotypes and Genes Book Excerpt:

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.

Genomic and Epigenomic Biomarkers of Toxicology and Disease

Genomic and Epigenomic Biomarkers of Toxicology and Disease
Author: Saura C. Sahu
Publsiher: John Wiley & Sons
Total Pages: 516
Release: 2022-04-21
ISBN: 1119807697
Category: Science
Language: EN, FR, DE, ES & NL

Genomic and Epigenomic Biomarkers of Toxicology and Disease Book Excerpt:

Genomic and Epigenomic Biomarkers of Toxicology and Disease The latest developments in biomarker research applicable to toxicology and medicine Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain. Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas. Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes: A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazard Comprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicine Practical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesothelioma In-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.

Biomarkers

Biomarkers
Author: Vishal S. Vaidya,Joseph V. Bonventre
Publsiher: John Wiley & Sons
Total Pages: 632
Release: 2010-10-05
ISBN: 0470452242
Category: Science
Language: EN, FR, DE, ES & NL

Biomarkers Book Excerpt:

This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.