The Enzyme Reference

Author by : Daniel L. Purich
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 94
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Description : The aim of this work is to provide a fuller spectrum of information in a single source on enzyme-catalyzed reactions than is currently available in any published reference work or as part of any Internet database. The Enzyme Reference: A Comprehensive Guidebook to Enzyme Nomenclature, Reactions, and Methods includes 20,000 review articles and seminal research papers. Additionally, it provides a novel treatment of so-called ATPase and GTPase reactions to account for the noncovalent substratelike and productlike states of molecular motors, elongation factors, transporters, DNA helicases, G-reulatory proteins, and other energases. Includes a compendium of over 6,000 enzyme reactions (including enzyme commission numbers, alternative names, substrates, products, alternative substrates, and properties) Covers over 900 chemical structures of key metabolites and cofactors Index directs readers to the exact pages for over 9,500 enzyme names


Enzyme Kinetics Catalysis And Control

Author by : Daniel L. Purich
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 68
Total Download : 939
File Size : 50,9 Mb
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Description : Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions


The Inhibitor Index

Author by : Daniel Purich
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 92
Total Download : 273
File Size : 53,8 Mb
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Description : Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,800 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers.


The Inhibitor Index

Author by : Daniel Purich
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 14
Total Download : 835
File Size : 53,6 Mb
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Description : Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,000 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers.


Enzyme Nomenclature 1978

Author by : Commission on Biochemical Nome
Languange : en
Publisher by : Elsevier
Format Available : PDF, ePub, Mobi
Total Read : 39
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Description : Enzyme Nomenclature (1978) is an attempt to address the problems and difficulties that arise in the naming of enzymes and coenzymes. In this regard, the International Union of Biochemistry established the International Commission on Enzymes with the task of creating a standard or code for the future naming of enzymes and to correct and organize the existing names and groups. The text is divided to five chapters where the last two are references and index to the enzyme list. Chapter 1 establishes the premise of the text and explains the historical development of the commissions. Chapter 2 meanwhile gives more details regarding the general principles of enzymes and their system of classification. The rules for classification and nomenclature, as well as the key to the numbering and classification, of enzymes are also discussed. Finally, Chapter 3 lists all of the enzymes under several groups such as hydrolases and ligases. The book will be a valuable source of reference not just for students but also for scientists and researchers in the field of biochemistry, applied science, and nutrition.


The Organic Chemistry Of Enzyme Catalyzed Reactions

Author by : Richard B. Silverman
Languange : en
Publisher by : Academic Press
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Total Read : 16
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Description : Written for advanced undergraduate and graduate students as well as professionals in organic and medicinal chemistry and biochemistry, this unique text illuminates the "black box" of enzyme-catalyzed reactions by showing how enzymes are simply highly efficient organic chemists. Enzyme-catalyzed reactions are essential for the design of enzyme inhibitors in the pharmaceutical and agricultural industries, and of growing importance for process development in the chemical and biotechnology industries. Following a general introduction to the role of enzymes as catalysts, each chapter describes the organic reaction mechanisms that are used by enzymes to catalyze a particular family of organic transformations. The compilation includes a vast number of drawings to illustrate structures and mechanisms, and focuses on one or two examples of enzymes that catalyze the particular chemistry for that transformation. The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather the general mechanisms used by enzymes. Extensive references refer to the many experiments that have helped to elucidate enzyme mechanisms. Chemical model studies as an aid in mechanistic studies are also discussed, as are the design of haptens and the generation of catalytic antibodies ("designer enzymes"). Problem sets and solutions are provided to check the reader's understanding of the principles described. * Shows how enzyme-catalyzed reactions are simply efficient organic reaction * Emphasizes the connection between organic reaction mechanisms and enzyme mechanisms * Explains how enzymes can accelerate the rates of chemical reactions withhigh specificity * Uses selected enzymes to demonstrate general mechanisms of enzyme-catalyzed reaction * Illustrated with a vast array of clearly drawn structures, schemes, and figures * Includes an extensive bibliography on enzyme mechanisms * Describes approaches to the design of enzyme inhibitors * Covers catalytic antibody design and mechanisms * Provides problem sets and solutions for each chapter * Written in an informal and engaging style


Handbook Of Proteolytic Enzymes

Author by : Alan J. Barrett
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 29
Total Download : 134
File Size : 42,7 Mb
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Description :


Comprehensive Biological Catalysis

Author by : Michael Sinnott
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 82
Total Download : 200
File Size : 50,5 Mb
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Description : Comprehensive Biological Catalysis: A Mechanistic Reference offers a comprehensive review of enzyme catalysis from a chemical perspective. This multi-volume work thoroughly covers background chemistry. The first volume concentrates on reactions of electrophilic carbon, phosphorous and sulfur. Volume Two provides reactions of nucleophilic/carbanoid carbon. Volume Three highlights radical reactions and oxidation/reduction. The final volume, or the chemical lexicon, consists of clear explanations of alphabetically-arranged specialized terms and concepts. A team of highly regarded authors and editors were gathered together to contribute to a clear and consistent coverage of enzyme catalysis. Offers the first comprehensive treatment of enzyme catalysis from a chemical viewpoint Lists enzyme reactions by chemical type rather than biological process catalyzed Presents enzyme catalysis from a chemical perspective Provides clear explanations of chemical concepts in chemical lexicon Contains rigorous reviewing and editing which result in coherent, fluid, non-overlapping text Features carefully selected authors and excellent indexing


Enzyme Handbook

Author by : Thomas E. Barman
Languange : en
Publisher by : Unknown
Format Available : PDF, ePub, Mobi
Total Read : 75
Total Download : 691
File Size : 53,8 Mb
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Description : Manual giving in concise form molecular data on some 800 enzymes. Entries include references. Vol. 2 has enzyme index.


Handbook Of Proteolytic Enzymes

Author by : Alan J. Barrett
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 65
Total Download : 397
File Size : 54,7 Mb
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Description : The third edition of the Handbook of Proteolytic Enzymes is a comprehensive reference work for the enzymes that cleave proteins and peptides, written by acknowledged experts in the field and containing over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. There are also introductory chapters on peptidase classification and mechanisms and a comprehensive index. For the first time, the Handbook is also available online via Elsevier's ScienceDirect platform as well as a three-volume book. The online version has enhanced options, including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors. This reference work is a must-have for biochemists, biotechnologists, molecular biologists and students in these disciplines, and will be of great interest to pharmaceutical and biotechnology companies. Contains over 830 chapters Covers new research in therapeutics and drug trials Supplies content written by experts in the field


A Study Of Enzymes

Author by : Stephen A. Kuby
Languange : en
Publisher by : CRC Press
Format Available : PDF, ePub, Mobi
Total Read : 97
Total Download : 589
File Size : 43,9 Mb
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Description : First published in 1990, this comprehensive monograph consists of two parts: Volume I, entitled Enzyme Catalysis, Kinetics, and Substrate Binding; and Volume II, entitled Mechanism of Enzyme Action. Volume I focuses on several aspects of enzyme catalytic behavior, their steady-state and transient-state kinetics, and the thermodynamic properties of substrate binding. Packed with figures, tables, schemes, and photographs, this volume contains over 1,000 references, including references regarding enzymology's fascinating history. This comprehensive book is of particular interest to enzymology students, teachers, and researchers. Volume II presents selected "cutting edge" examples of techniques and approaches being pursued in biochemistry. This up-to-date resource includes 11 chapters, which illustrate important theoretical and practical aspects of enzyme mechanisms. It also features selected examples in which today's most important techniques, ideas, and theories are used to elaborate on the intricate nature of enzyme action mechanisms. This particular volume provides important information for both the novice and the seasoned investigator.


Enzyme Nomenclature

Author by : Commission on Biochemical Nomenclature
Languange : en
Publisher by : Elsevier Science & Technology
Format Available : PDF, ePub, Mobi
Total Read : 63
Total Download : 495
File Size : 49,7 Mb
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Description : 1770 enzymes listed with classification number, recommended name, reaction, other names, basis for classification, comments, and reference numbers. Classified arrangement. Contains list of over 2700 references. Index to the enzyme list, Subject index.


Enzyme Kinetics

Author by : Hans Bisswanger
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 40
Total Download : 516
File Size : 41,8 Mb
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Description : Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.


Enzyme Active Sites And Their Reaction Mechanisms

Author by : Harry Morrison
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 41
Total Download : 882
File Size : 40,9 Mb
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Description : Enzyme Active Sites and their Reaction Mechanisms provides a one-stop reference on how enzymes "work." Here, Dr. Harry Morrison, PhD and Professor Emeritus at Purdue University, provides a detailed overview of the origin and function of forty enzymes, the chemical details of their active sites, their mechanisms of action, and associated cofactors. The enzymes featured highlight a step forward, along with possible areas of application, thus supporting new research in academic and industrial labs. Each chapter is written in a clear format, including a brief summary of enzyme function and structure, a detailed description of their mechanisms of action and associated co-factors. Offers a comprehensive, biochemical understanding of enzyme mechanisms and their reaction sites Supports new research in academic, medical and industrial labs, connecting discoveries powered by recent advances in technology and experimental approaches to areas of application Features short, carefully structured, actionable chapters on various enzyme classes, thus allowing for easy-use and searchability


Behaviour Of Salivary Amylase In Various Reaction Environments With Reference To Km And Vmax An Overview

Author by : Prem Jose Vazhacharickal
Languange : en
Publisher by : GRIN Verlag
Format Available : PDF, ePub, Mobi
Total Read : 41
Total Download : 590
File Size : 46,7 Mb
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Description : Scientific Study from the year 2016 in the subject Chemistry - Bio-chemistry, grade: 1.5, Mar Augusthinose College, language: English, abstract: Amylase is an enzyme which catalyzes the hydrolysis of α (1, 4)-glycosidic linkages in amylose (a linear form of starch), amylopectin (a branched form of starch) and glycogen into simpler carbohydrate molecules such as oligosaccharides or disaccharides. Alpha-amylase is the major form of amylase found in human, most prominently in pancreatic juice and saliva. The salivary amylase is an amylolytic enzyme, which can acts on cooked or boiled starch and converts it in to maltose. So it became interesting to study the behaviour of salivary amylase, when it is secreted as result of different stimuli. And thus began to study the effect of five different stimulatory temperatures, and also the effect of four tastes on the behaviour of salivary amylase. For the study of stimulatory effect of temperature on salivary amylase, five different temperatures are selected (4, 27, 37, 55 and 75°C). And likewise four tastes also selected (sweet, sour, salt and bitter). The DNS method was done in the both tests to obtain the absorbance at 520 nm. The samples were collected from three people, of same age. The saliva was collected at same time, after one and a half hour of their breakfast in order to maintain a controlled condition for this study. In each cases the incubation temperature also kept as variable (4, 27, 37, 55 and 75°C). This study was also aimed to determine the behaviour of salivary amylase with reference to the kinetic parameters like Km and Vmax of salivary alpha amylase by incubating the enzyme (stimulated by different stimulatory conditions of temperature and taste) with varying concentration of substrate. The study revealed the consistency in kinetic parameters like Km and Vmax of salivary alpha amylase secreted in response to various stimuli.


Enzymes Catalysis Kinetics And Mechanisms

Author by : N.S. Punekar
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 76
Total Download : 228
File Size : 46,9 Mb
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Description : This enzymology textbook for graduate and advanced undergraduate students covers the syllabi of most universities where this subject is regularly taught. It focuses on the synchrony between the two broad mechanistic facets of enzymology: the chemical and the kinetic, and also highlights the synergy between enzyme structure and mechanism. Designed for self-study, it explains how to plan enzyme experiments and subsequently analyze the data collected. The book is divided into five major sections: 1] Introduction to enzymes, 2] Practical aspects, 3] Kinetic Mechanisms, 4] Chemical Mechanisms, and 5] Enzymology Frontiers. Individual concepts are treated as stand-alone chapters; readers can explore any single concept with minimal cross-referencing to the rest of the book. Further, complex approaches requiring specialized techniques and involved experimentation (beyond the reach of an average laboratory) are covered in theory with suitable references to guide readers. The book provides students, researchers and academics in the broad area of biology with a sound theoretical and practical knowledge of enzymes. It also caters to those who do not have a practicing enzymologist to teach them the subject.


Essential Enzyme Kinetics

Author by : Daniel L. Purich
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 14
Total Download : 549
File Size : 50,8 Mb
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Description : Essential Enzyme Kinetics: A Textbook for Molecular Life Scientists describes the theoretical basis and best-practice approaches for using initial-rate, fast reaction, and kinetic isotope effect experiments to define enzyme catalysis. Because a detailed knowledge of enzyme transition-states is the main driver for the rational design of slow, tight-binding inhibitors destined to become tomorrow's small-molecule drugs, Essential Enzyme Kinetics is the must-have reference for chemists, biochemists, and pharmacologists intent on pursuing careers in Big Pharma. Given the interdisciplinary nature of contemporary drug development, this book provides a lucid short-course that will also benefit nonspecialists seeking to understand the scope and reach of modern enzyme kinetics. Provides practical information about how to work with enzymes and design experiments to identify new inhibitors or activators Includes detailed step-by-step derivations of rate equations, showing tried-and-true ways to confirm that the equations obtained are correct Arranged for use both as a desk reference (with over 200 equations and more than 400 key references) or as a textbook (with 8-10 problems/exercises at the end of each chapter)


Enzymes In Food Technology

Author by : Mohammed Kuddus
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 61
Total Download : 565
File Size : 55,5 Mb
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Description : The integration of enzymes in food processing is well known, and dedicated research is continually being pursued to address the global food crisis. This book provides a broad, up-to-date overview of the enzymes used in food technology. It discusses microbial, plant and animal enzymes in the context of their applications in the food sector; process of immobilization; thermal and operational stability; increased product specificity and specific activity; enzyme engineering; implementation of high-throughput techniques; screening of relatively unexplored environments; and development of more efficient enzymes. Offering a comprehensive reference resource on the most progressive field of food technology, this book is of interest to professionals, scientists and academics in the food and biotech industries.


The Complete Book Of Enzyme Therapy

Author by : Anthony J. Cichoke
Languange : en
Publisher by : Penguin
Format Available : PDF, ePub, Mobi
Total Read : 70
Total Download : 811
File Size : 52,6 Mb
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Description : Describes a variety of ailments and medical conditions, and lists and current treatments that feature enzymes, vitamins, and minerals


Enzyme Nomenclature 1984

Author by : Edwin Clifford Webb
Languange : en
Publisher by : Academic Press
Format Available : PDF, ePub, Mobi
Total Read : 32
Total Download : 401
File Size : 44,6 Mb
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Description : Lists 2477 enzymes with classification number, recommended name, reaction, other names, basis for classification, comments, and reference numbers. Classified arrangement. Contains bibliography of 4478 references. Index to the enzyme list.


Enzyme Handbook

Author by : Thomas E. Barman
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 86
Total Download : 694
File Size : 46,6 Mb
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Description : I t is a pleasure to write a few lines to welcome this labour of Iove. I t is always dangeraus to draw sharp divisions between the interests of different scientists. However, in the present stage of progress in enzymology, there are those who are primarily interested in the molecular mechanisms of the reactions of a few selected enzymes, while others are involved in the grand scheme of the chemical metabolism of cells or whole organisms. Fortunately Dr. Barman has had experience in both the molecular and the metabolic aspects of enzymology. He therefore knows the require ments of research workers interested in enzymes from many different points of view. It would be foolish to hope that a handbook of this kind will provide all the information about enzymes which different specialists would wish to find. The author has attempted to help users in the following way. If one Iooks up a particular enzyme one will find all the basic data and a very good Iist of references for more specialized information. Apart from selection of the type of information provided, the author's judgement on the reliability of data is, of course, of critical importance in a handbook. If contradicting published information about some property of an enzyme has to be sorted out, it is often neither possible to teil the whole story nor to give an objective judgement.


Fundamentals Of Enzyme Engineering

Author by : Young Je Yoo
Languange : en
Publisher by : Springer
Format Available : PDF, ePub, Mobi
Total Read : 19
Total Download : 394
File Size : 53,8 Mb
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Description : This book provides a comprehensive introduction to all aspects of enzyme engineering, from fundamental principles through to the state-of-the-art in research and industrial applications. It begins with a brief history, describing the milestones of advancement in enzyme science and technology, before going on to cover the fundamentals of enzyme chemistry, the biosynthesis of enzymes and their production. Enzyme stability and the reaction kinetics during enzymatic reactions are presented to show how enzymes function during catalysis and the factors that affect their activity. Methods to improve enzyme performance are also presented, such as cofactor regeneration and enzyme immobilization. The book emphasizes and elaborates on the performance and characteristics of enzymes at the molecular level. Finally, the book presents recent advances in enzyme engineering and some key industrial application of enzymes addressing the present needs of society. This book presents essential information not only for undergraduate and graduate students, but also for researchers in academia and industry, providing a valuable reference for the development of commercial applications of enzyme technology.