The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols
Author: Warren H. Finlay
Publsiher: Academic Press
Total Pages: 302
Release: 2019-06-01
ISBN: 0081027869
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

The Mechanics of Inhaled Pharmaceutical Aerosols Book Excerpt:

The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Transient Deposition of Particles with Applications to Inhaled Pharmaceutical Aerosols

Transient Deposition of Particles with Applications to Inhaled Pharmaceutical Aerosols
Author: Philip S. Ophus
Publsiher: Unknown
Total Pages: 135
Release: 2011
ISBN: 1928374650XXX
Category: Aerosol therapy
Language: EN, FR, DE, ES & NL

Transient Deposition of Particles with Applications to Inhaled Pharmaceutical Aerosols Book Excerpt:

Pharmaceutical Inhalation Aerosol Technology

Pharmaceutical Inhalation Aerosol Technology
Author: Anthony J. Hickey,Sandro R. Da Rocha
Publsiher: CRC Press
Total Pages: 728
Release: 2019-03-21
ISBN: 9781138063075
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Pharmaceutical Inhalation Aerosol Technology Book Excerpt:

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Pharmaceutical Inhalation Aerosol Technology Third Edition

Pharmaceutical Inhalation Aerosol Technology  Third Edition
Author: Anthony J. Hickey,Sandro R. da Rocha
Publsiher: CRC Press
Total Pages: 730
Release: 2019-03-26
ISBN: 0429619561
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmaceutical Inhalation Aerosol Technology Third Edition Book Excerpt:

This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

CFD Assessment of Respiratory Drug Delivery Efficiency in Adults and Improvements Using Controlled Condensational Growth

CFD Assessment of Respiratory Drug Delivery Efficiency in Adults and Improvements Using Controlled Condensational Growth
Author: Ross Lawrence Walenga
Publsiher: Unknown
Total Pages: 660
Release: 2014
ISBN: 1928374650XXX
Category: Aerosols
Language: EN, FR, DE, ES & NL

CFD Assessment of Respiratory Drug Delivery Efficiency in Adults and Improvements Using Controlled Condensational Growth Book Excerpt:

Pharmaceutical aerosols provide a number of advantages for treating respiratory diseases that include targeting high doses directly to the lungs and reducing exposure of other organs to the medication, which improve effectiveness and minimize side effects. However, difficulties associated with aerosolized drug delivery to the lungs include drug losses in delivery devices and in the extrathoracic region of human upper airways. Intersubject variability of extrathoracic and thoracic drug deposition is a key issue as well and should be minimized. Improvements to respiratory drug delivery efficiency have been recently proposed by Dr. P. Worth Longest and Dr. Michael Hindle through the use controlled condensational growth methods, which include enhanced condensational growth (ECG) and excipient enhanced growth (EEG). These methods reduce inhaled drug loss through the introduction of an aerosol with an initial submicrometer aerodynamic diameter, which then experiences condensational growth to increase droplet size and enhance thoracic deposition. Tracheobronchial and nasal human airway computational models were developed for this study to assess drug delivery using conventional and EEG methods. Computational versions of these models are used to assess drug delivery and variability with computational fluid dynamics (CFD) simulations, which are validated with experimental data where possible. Using CFD, steady state delivery of albuterol sulfate (AS) during high flow therapy (HFT) through a nasal cannula was characterized with four nasal models developed for this study, with results indicating an increase in average delivered dose from 24.0% with a conventional method to 82.2% with the EEG technique and an initially sized 0.9 [micro]m aerosol, with a corresponding decrease in the coefficient of variation from 15% to 3%. Transient CFD simulations of nebulized AS administration through a mask during noninvasive positive pressure ventilation (NPPV) were performed and validated with experimental data, which resulted in 40.5% delivered dose with the EEG method as compared with 19.5% for a conventional method and a common inhalation profile. Using two newly created face-nose-mouth-throat models, dry powder delivery of ciprofloxacin during NPPV was assessed for the first time with steady state CFD predictions, which showed an increase in average delivered lung dose through a new mask design of 78.2% for the EEG method as compared with 36.2% for conventional delivery, while corresponding differences in delivered dose between the two models were reduced from 45.4% to 12.8% with EEG. In conclusion, results of this study demonstrate (i) the use of highly realistic in silico and in vitro models to predict the lung delivery of inhaled pharmaceutical aerosols, (ii) indicate that the EEG approach can reduce variability in nose-to-lung aerosol delivery through a nasal cannula by a factor of five, and (iii) introduce new high efficiency methods for administering aerosols during NPPV, which represents an area of current clinical need.

Proceedings of the 7th Biennial Conference on Engineering Systems Design and Analysis 2004

Proceedings of the 7th Biennial Conference on Engineering Systems Design and Analysis  2004
Author: Anonim
Publsiher: Amer Society of Mechanical
Total Pages: 724
Release: 2004
ISBN: 1928374650XXX
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Proceedings of the 7th Biennial Conference on Engineering Systems Design and Analysis 2004 Book Excerpt:

Atomization and Sprays

Atomization and Sprays
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2008
ISBN: 1928374650XXX
Category: Atomization
Language: EN, FR, DE, ES & NL

Atomization and Sprays Book Excerpt:

Journal de la Soci t Royale D astronomie Du Canada

Journal de la Soci  t   Royale D astronomie Du Canada
Author: Royal Astronomical Society of Canada
Publsiher: Unknown
Total Pages: 135
Release: 2006
ISBN: 1928374650XXX
Category: Astronomy
Language: EN, FR, DE, ES & NL

Journal de la Soci t Royale D astronomie Du Canada Book Excerpt:

"Library catalogue in 1911" (31 p.) appended to v. 4.

New Research Centers

New Research Centers
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2008
ISBN: 1928374650XXX
Category: Learned institutions and societies
Language: EN, FR, DE, ES & NL

New Research Centers Book Excerpt:

International Research Centers Directory

International Research Centers Directory
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2009
ISBN: 1928374650XXX
Category: Research institutes
Language: EN, FR, DE, ES & NL

International Research Centers Directory Book Excerpt:

Inhaled Pharmaceutical Product Development Perspectives

Inhaled Pharmaceutical Product Development Perspectives
Author: Anthony J. Hickey
Publsiher: Elsevier
Total Pages: 110
Release: 2017-11-23
ISBN: 0128123362
Category: Science
Language: EN, FR, DE, ES & NL

Inhaled Pharmaceutical Product Development Perspectives Book Excerpt:

Inhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. The book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future. Discusses development strategies and best practices in the context of regulatory requirements Written by a broadly qualified expert drawing on the knowledge and critical opinions of key individuals in the field Includes a foreword by Charles G. Thiel

The British National Bibliography

The British National Bibliography
Author: Arthur James Wells
Publsiher: Unknown
Total Pages: 135
Release: 2002
ISBN: 1928374650XXX
Category: Bibliography, National
Language: EN, FR, DE, ES & NL

The British National Bibliography Book Excerpt:

Powders and Grains 2009

Powders and Grains 2009
Author: Masami Nakagawa,Stefan Luding
Publsiher: Amer Inst of Physics
Total Pages: 1124
Release: 2009-06-26
ISBN: 1928374650XXX
Category: Science
Language: EN, FR, DE, ES & NL

Powders and Grains 2009 Book Excerpt:

Powders and Grains is an international scientific conference held every 4 years that brings together engineers and physicists interested in the microcmechanics of granular media, powders and grains. The meetings are organized by AEMMG (Association pour L'Etude de la Micromecanique des Milieux Granulaires). Previous meetings were held in Clement-Ferrand, France (1989), Birmingham, England (1993), Durham, USA (1997), Sendai, Japan (2001), and in Stuttgart, Germany (2005). Powders & Grains distinguishes itself from other meetings on granular materials in two ways: (1) It brings together both engineers and physicists. (2) It emphasizes the micromechanics of granular materials. The conference program includes contributions from experts around the world related to the general topic of granular media.

Vapor Transport and Aerosol Dynamics in the Respiratory Airways

Vapor Transport and Aerosol Dynamics in the Respiratory Airways
Author: Geng Tian
Publsiher: Unknown
Total Pages: 135
Release: 2011
ISBN: 1928374650XXX
Category: Aerosols
Language: EN, FR, DE, ES & NL

Vapor Transport and Aerosol Dynamics in the Respiratory Airways Book Excerpt:

Predicting vapor transport and aerosol dynamics in the respiratory airways is important for analyzing both environmental exposure and respiratory drug delivery. A large number of analytical models, computational studies, and experiments on vapor and aerosol transport in the respiratory tract have been conducted previously. However, a number of critical questions remain unanswered. In this study, computational fluid dynamics (CFD) is primarily employed with frequent comparisons to existing and new experimental data sets to address previously unanswered issues related to the transport of vapors and aerosol in the respiratory tract. The three objectives of this study are further described below. Objective 1: A CFD model was developed to predict the transient absorption of inhaled vapors in the respiratory tract. Results indicated that transient absorption can significantly influence the transport and uptake of vapors in the walls of the conducting airways. Objective 2: The concept of enhanced condensational growth (ECG) applied to respiratory drug delivery was tested in a representative airway model extending from the oral cavity to the end of the tracheobronchial (TB) airways. Results indicated that ECG is an effective method to provide near full lung retention of the aerosol. The CFD results also indicated that the ECG delivery approach under transient inhalation conditions increased aerosol deposition in the TB airways by only a small amount, as compared with steady state conditions. Objective 3: The effect of transient waveforms on the transport and deposition of pharmaceutical aerosols from inhalers in the upper airways was considered. Results indicated that the CFD model predictions matched the in vitro experiments to a high degree. The CFD results also indicated that it was critical to consider transient inhalation effects when assessing aerosol deposition. The stochastic individual path (SIP) modeling approach was then introduced and implemented to evaluate the transport and deposition of pharmaceutical aerosols from inhalers in medium and small TB airways. Results indicated that steady state inhalation could be used to predict deposition efficiencies in the TB airways between the 4th branch (B4) and the bronchioles (B15).

Journal of Biomechanical Engineering

Journal of Biomechanical Engineering
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2009
ISBN: 1928374650XXX
Category: Bioengineering
Language: EN, FR, DE, ES & NL

Journal of Biomechanical Engineering Book Excerpt:

Indian Journal of Experimental Biology

Indian Journal of Experimental Biology
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 2007
ISBN: 1928374650XXX
Category: Biology
Language: EN, FR, DE, ES & NL

Indian Journal of Experimental Biology Book Excerpt:

Pharmaceutical Practice

Pharmaceutical Practice
Author: Arthur J. Winfield,R. Michael E. Richards
Publsiher: Unknown
Total Pages: 523
Release: 1998
ISBN: 1928374650XXX
Category: Dosage Forms
Language: EN, FR, DE, ES & NL

Pharmaceutical Practice Book Excerpt:

Introducing the 2nd Edition of the standard text on pharmaceutical practice. Totally rewritten and updated, this book describes the day- to-day activities of the hospital or community pharmacist, including the preparation and dispensing of medication and the pharmacist-patient relationship. This edition also features new chapters and chapter summary boxes throughout.

Inhaled Medicines

Inhaled Medicines
Author: Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
Publsiher: Academic Press
Total Pages: 438
Release: 2021-01-20
ISBN: 0128149752
Category: Business & Economics
Language: EN, FR, DE, ES & NL

Inhaled Medicines Book Excerpt:

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ● Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ● Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ● Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ● Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

The American Review of Respiratory Disease

The American Review of Respiratory Disease
Author: Anonim
Publsiher: Unknown
Total Pages: 135
Release: 1993-10
ISBN: 1928374650XXX
Category: Respiratory organs
Language: EN, FR, DE, ES & NL

The American Review of Respiratory Disease Book Excerpt:

Includes Abstracts section, previously issued separately.

Inhalation Aerosols

Inhalation Aerosols
Author: Anthony J. Hickey
Publsiher: CRC Press
Total Pages: 536
Release: 1996-06-07
ISBN: 9781420002256
Category: Medical
Language: EN, FR, DE, ES & NL

Inhalation Aerosols Book Excerpt:

This unique reference integrates the theory and practical use of aerosols in inhalation therapy into a single resource-presenting the physical chemistry of formulation, the physics of aerosol generation, aerodynamic behavior, and therapeutic implications. Offers up-to-date techniques for droplet and particle generation, including air-blast and ultrasonic nebulizers, propellant-driven metered-dose inhalers, dry-powder inhalers, and elecctrospray systems!