Description : "Many scientists today are working to retard the aging process in humans so as to increase both life expectancy and the quality of life. Over the past decade impressive results have been achieved in targeting the mechanisms and pathways of aging. In The Quest for Human Longevity, Lewis D. Solomon considers these scientific studies by exploring the principal biomedical anti-aging techniques. The book also considers cutting edge research on mental enhancements and assesses the scientific doubts of skeptics. The Quest for Human Longevity is also about business. Solomon examines eight corporations pursuing various age-related interventions, profiling their scientific founders and top executives, and examining personnel, intellectual property, and financing for each firm. Academic scientists form the link between research and commerce. Solomon notes that the involvement of university scientists and researchers follows one of two models. The first is a traditional model in which scientists leave academia to work for a corporation or remain in academia and obtain business support for their research. The second is a modern model in which scientists use their intellectual property as a catalyst for acquiring equity interests in the firms they organize. Critics have pointed to the dangers of commercialized science, but Solomon's analysis, on balance, finds that the benefits outweigh the costs and that problems of secrecy and conflicts of interest can be addressed. If scientists succeed in unlocking the secrets of aging and developing drugs or therapies that will allow us to live decades longer, the consequences for society will include profound social, political, economic, and ethical questions. Solomon deals with the public policy aspects of significant life extension and looks at the conflict between those who advocate the acceptance of mortality and the partisans of life. The Quest for Human Longevity will be of interest to policymakers, sociologists, scientists, and studen"
Description : An exploration of human longevity discusses the real link between good health and lifespan, the role of genes in lifespan, the danger of infectious disease, and diet and life expectancy. 25,000 first printing. Tour.
Description : In the last two decades, due to the continuous increase of lifespans in Western societies, and the consequent growing of the elderly population, have witnessed an increase in the number of studies on biological and molecular factors able to promote healthy aging and reach longevity. The study of the genetic component of human longevity demonstrated that it accounts for 25% of intra population phenotype variance. The efforts made to characterize the genetic determinants suggested that the maintenance of cellular integrity, inflammation, oxidative stress response, DNA repair, as well as the use of nutrients, represent the most important pathways correlated with a longer lifespan. However, although a plethora of variants were indicated to be associated with human longevity, only very few were successfully replicated in different populations, probably because of population specificity, missing heritability as well as a complex interaction among genetic factors with lifestyle and cultural factors, which modulate the individual chance of living longer. Thus, many challenges remain to be addressed in the search for the genetic components of human longevity. This Special Issue is aimed to unify the progress in the analysis of the genetic determinants of human longevity, to take stock of the situation and point to future directions of the field. We invite submissions for reviews, research articles, short-communications dealing with genetic association studies in human longevity, including all types of genetic variation, as well as the characterization of longevity-related genes.
Description : With the help of medicine and technology we are living longer than ever before. As human life spans have increased, the moral and political issues surrounding longevity have become more complex. Should we desire to live as long as possible? What are the social ramifications of longer lives? How does a longer life span change the way we think about the value of our lives and about death and dying? Christine Overall offers a clear and intelligent discussion of the philosophical and cultural issues surrounding this difficult and often emotionally charged issue. Her book is unique in its comprehensive presentation and evaluation of the arguments—both ancient and contemporary—for and against prolonging life. It also proposes a progressive social policy for responding to dramatic increases in life expectancy. Writing from a feminist perspective, Overall highlights the ways that our biases about race, class, and gender have affected our views of elderly people and longevity, and her policy recommendations represent an effort to overcome these biases. She also covers the arguments surrounding the question of the "duty to die" and includes a provocative discussion of immortality. After judiciously weighing the benefits and the risks of prolonging human life, Overall persuasively concludes that the length of life does matter and that its duration can make a difference to the quality and value of our lives. Her book will be an essential guide as we consider our social responsibilities, the meaning of human life, and the prospects of living longer.
Description : Though exceptional human longevity has captured the imagination for millennia, it has been only in the past fifteen years or so that some of the secrets to very long lives are finally giving way to scientific inquiry. Written by an international group of experts, this year's review first considers the methodological and design dilemmas faced in conducting centenarian research. It then offers guidance in locating literature and data sources for primary and secondary information on centenarians and the oldest old. This section includes a list of the world's oldest persons and discusses the difficulties in compiling such a list. The remainder of the review is divided in three sections-the biology and genetics of longevity, the behavioral and social predictors of longevity, and methodological issues in qualitative and anthropologic approaches and the study of the very oldest old, supercentenarians, or those who live to 110 years or more. Data is drawn from studies undertaken among populations in diverse parts of the world.
Description : The progressive ageing of the general population and the consequent increase of the number of old people has made the typical medical problems of aged people more frequently observed, and particularly the problems related to the ageing brain. This new book is an updated overview of relevant aspects of cognitive decline associated with ageing. Within the wide landscape of brain ageing the authors reconsider the role of the main predisposing factors and risk factors on the development of various form of mental decline, from mild cognitive impairment to dementia. The strength of this book is the large, updated overview of the most recent data of scientific literature regarding the role of genetic, metabolic and environmental factors on the predisposition and onset of cognitive decline. Particular attention is paid to the dietary micro- and macronutrients and to their possible role in the pathogenesis of the various form of dementigen disorders.
Description : In The Youth Pill, journalist David Stipp explores the scientific battle against aging and the pioneers of the movement to extend lifespan for everyone. He takes readers behind the scenes and introduces us to the key players who are experimenting with the most promising cutting-edge research. It is an informative and provocative read that shows how a small group of optimistic and determined scientists are closing in on drugs that will change the way we live forver.
Description : This newest edition of a core graduate level textbook has added six new chapters to further enrich the ìgerontological imagination,î and encourage an interdisciplinary approach to the study of aging. Academically rigorous yet clear and accessible, the text provides the most current findings from leading gerontological researchers and practitioners. New and updated chapters examine biology, exercise science/nutrition, communication science, geriatric medicine and nursing, demography, anthropology, economics, human development, psychology, political science, sociology, social work, and law, to provide broadly drawn perspectives on the study of aging. Special emphasis is placed on current challenges regarding policy and service delivery in the face of fiscal uncertainty. Additionally, this new edition covers international outlooks on aging given the increasing influence of globalization on individual lives. By interweaving knowledge from a broad range of disciplines, Wilmoth and Ferraro have created a comprehensive picture of gerontology today that will enhance course instruction and provide a new window into the future of the discipline. New chapters address: Geriatric medicine and nursing Communication disorders and aging International and cross-cultural perspectives on aging Public policy and the needs of diverse aging populations Geriatric social work Legal perspectives on aging Key Features: Interweaves current gerontological research and ideas from multiple disciplines Addresses biology, psychology, human development, sociology, and economics as they relate to gerontology Presents additional disciplinary perspectives including exercise science/nutrition, communication science, geriatric medicine and nursing, demography, anthropology, political science, social work, and law. Includes Ferraroís classic chapter on ìThe Gerontological Imaginationî
Description : A work of scientific investigation covers researchers at the frontier of science studying the repair and protective maintenance mechanisms of DNA, which may hold the solutions to the problems of the aging process