Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors
Author: Harun M. Patel,Rahul Pawara,Sanjay J. Surana
Publsiher: Elsevier
Total Pages: 208
Release: 2018-11-27
ISBN: 0081026625
Category: Medical
Language: EN, FR, DE, ES & NL

Third Generation EGFR Inhibitors Book Excerpt:

Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics. Includes full synthetic schemes of all approved and in-trial third generation inhibitors Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity

A Beginner s Guide to Targeted Cancer Treatments

A Beginner s Guide to Targeted Cancer Treatments
Author: Elaine Vickers
Publsiher: John Wiley & Sons
Total Pages: 360
Release: 2018-05-08
ISBN: 1119126835
Category: Medical
Language: EN, FR, DE, ES & NL

A Beginner s Guide to Targeted Cancer Treatments Book Excerpt:

The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

Frontiers in Anti Cancer Drug Discovery Volume 11

Frontiers in Anti Cancer Drug Discovery  Volume 11
Author: Atta-ur-Rahman ,Muhammad Iqbal Choudhary
Publsiher: Bentham Science Publishers
Total Pages: 163
Release: 2020-09-01
ISBN: 9811422125
Category: Medical
Language: EN, FR, DE, ES & NL

Frontiers in Anti Cancer Drug Discovery Volume 11 Book Excerpt:

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The eleventh volume of the series focuses on reviews on targeted therapies and drug delivery systems. This volume covers the following topics: - PI3K/Akt/mTOR Pathway in Acute Lymphoblastic Leukemia Targeted Therapies - Polymeric Nanomedicines in Treatment of Breast Cancer: Review of Contemporary Research - Treatment of Lung Cancer in the New Era - Oral Administration of Cancer Chemotherapeutics Exploiting Self-Nanoemulsifying Drug Delivery System: Recent Progress and Application - Targeting Approaches for the Diagnosis and Treatment of Cancer.

Natural Products as Enzyme Inhibitors

Natural Products as Enzyme Inhibitors
Author: Vijay L. Maheshwari
Publsiher: Springer Nature
Total Pages: 135
Release: 2022
ISBN: 9811909326
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Natural Products as Enzyme Inhibitors Book Excerpt:

Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma

Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma
Author: Caroline Amalia Nebhan
Publsiher: Unknown
Total Pages: 145
Release: 2014
ISBN: 1928374650XXX
Category: Electronic dissertations
Language: EN, FR, DE, ES & NL

Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma Book Excerpt:

Chemoinformatics Approaches to Structure and Ligand Based Drug Design

Chemoinformatics Approaches to Structure  and Ligand Based Drug Design
Author: Adriano D. Andricopulo,Leonardo L. G. Ferreira
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2019-02-05
ISBN: 2889457443
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Chemoinformatics Approaches to Structure and Ligand Based Drug Design Book Excerpt:

Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the use of chemoinformatics in drug design. To that end, experts in all areas of drug discovery have made their knowledge available through a series of articles that report state-of-the-art approaches. Readers are provided with outstanding contributions focusing on a wide variety of topics which will be of great value to those interested in the many different and exciting facets of drug design.

Protein Kinase Inhibitors

Protein Kinase Inhibitors
Author: Md. Imtaiyaz Hassan,Saba Noor
Publsiher: Academic Press
Total Pages: 830
Release: 2022-05-19
ISBN: 0323913490
Category: Science
Language: EN, FR, DE, ES & NL

Protein Kinase Inhibitors Book Excerpt:

Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development. Provides a thorough overview of kinase inhibitor biology and its role in disease progression and modulation Examines protein kinase inhibitor drugs in various stages of clinical trials and development Offers methods and protocols for protein kinase inhibitor research studies and drug design and development Includes chapter contributions from international leaders in the field

Targeted Therapies for Lung Cancer

Targeted Therapies for Lung Cancer
Author: Ravi Salgia
Publsiher: Springer
Total Pages: 238
Release: 2019-06-26
ISBN: 3030178323
Category: Medical
Language: EN, FR, DE, ES & NL

Targeted Therapies for Lung Cancer Book Excerpt:

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Practical Medical Oncology Textbook

Practical Medical Oncology Textbook
Author: Antonio Russo,Marc Peeters,Lorena Incorvaia,Christian Rolfo
Publsiher: Springer Nature
Total Pages: 1112
Release: 2021-10-06
ISBN: 3030560511
Category: Medical
Language: EN, FR, DE, ES & NL

Practical Medical Oncology Textbook Book Excerpt:

This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology. Providing a systematic overview of all types of solid tumors, including epidemiology and cancer prevention, genetic aspects of hereditary cancers, differential diagnosis, typical signs and symptoms, diagnostic strategies and staging, and treatment modalities, it also discusses new and innovative cancer treatments, particularly targeted therapy and immunotherapy. Expert commentaries at the end of each chapter highlight key points, offer insights, suggest further reading and discuss clinical application using case descriptions. This textbook is an invaluable, practice-oriented tool for medical students just beginning their clinical oncology studies, as well as for medical oncology residents and young professionals.

Proteinkinase Inhibitors

Proteinkinase Inhibitors
Author: Stefan Laufer
Publsiher: Springer Nature
Total Pages: 256
Release: 2021-03-23
ISBN: 3030681807
Category: Science
Language: EN, FR, DE, ES & NL

Proteinkinase Inhibitors Book Excerpt:

This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular attention is given to Inhibitors of c-Jun N-terminal kinase 3, and to covalent Janus Kinase 3 Inhibitors. A case study on Receptor Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book. Given its breath, this book will appeal to medicinal chemists, students, researchers and professionals alike.

AACR 2016 Abstracts 2697 5293

AACR 2016  Abstracts 2697 5293
Author: American Association for Cancer Research (AACR)
Publsiher: CTI Meeting Technology
Total Pages: 135
Release: 2016-03-28
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

AACR 2016 Abstracts 2697 5293 Book Excerpt:

The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.

AACR 2016 Abstracts 1 2696

AACR 2016  Abstracts 1 2696
Author: American Association for Cancer Research (AACR)
Publsiher: CTI Meeting Technology
Total Pages: 135
Release: 2016-03-28
ISBN: 1928374650XXX
Category: Medical
Language: EN, FR, DE, ES & NL

AACR 2016 Abstracts 1 2696 Book Excerpt:

The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 1-2696 presented on April 17-18, 2016, at the AACR Annual Meeting.

Lung Cancer

Lung Cancer
Author: Anne C. Chiang,Roy S. Herbst
Publsiher: Springer Nature
Total Pages: 264
Release: 2021
ISBN: 3030740285
Category: Cancer
Language: EN, FR, DE, ES & NL

Lung Cancer Book Excerpt:

Lung cancer has seen a paradigm shift in disease treatment over the past few years, with major changes in the therapeutic drugs now available as well as in the overall management approach. For targeted and immunotherapeutic approaches, understanding the biology of acquired resistance is a key strategy that has yielded productive advances in the subsequent treatment. Future advances also include incorporating biomarker data obtained from solid and liquid biopsies, as well as combination of immunotherapy with radiotherapy and in special populations such patients with CNS involvement.

AACR 2018 Proceedings Abstracts 1 3027

AACR 2018 Proceedings  Abstracts 1 3027
Author: American Association for Cancer Research
Publsiher: CTI Meeting Technology
Total Pages: 135
Release: 2018-04-10
ISBN: 1370257430
Category: Electronic Book
Language: EN, FR, DE, ES & NL

AACR 2018 Proceedings Abstracts 1 3027 Book Excerpt:

Kinase Drug Discovery

Kinase Drug Discovery
Author: Richard A. Ward,Frederick W. Goldberg
Publsiher: Royal Society of Chemistry
Total Pages: 414
Release: 2018-10-10
ISBN: 1788010833
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Kinase Drug Discovery Book Excerpt:

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years.

Protein Kinases

Protein Kinases
Author: Anonim
Publsiher: BoD – Books on Demand
Total Pages: 162
Release: 2021-12-08
ISBN: 1838809066
Category: Medical
Language: EN, FR, DE, ES & NL

Protein Kinases Book Excerpt:

For the past two decades, the protein kinase family has been an intense area of research for developing anticancer drugs. Despite tremendous advancements in kinase drug expansion, many kinases are still unexplored. As such, this book includes research and review articles from experts that focus on protein kinase signalling pathways as a molecular drug target. Chapters include illustrations and cover such topics as the mechanism of action and anticancer activity of protein kinase inhibitors on various cancer types. They also discuss new opportunities, challenges, and future perspectives in the field.

Molecular Targeted Therapy of Lung Cancer

Molecular Targeted Therapy of Lung Cancer
Author: Yuichi Takiguchi
Publsiher: Springer
Total Pages: 327
Release: 2017-01-24
ISBN: 9811020027
Category: Medical
Language: EN, FR, DE, ES & NL

Molecular Targeted Therapy of Lung Cancer Book Excerpt:

This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

Resistance to Anti Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways

Resistance to Anti Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
Author: Yosef Yarden,Moshe Elkabets
Publsiher: Springer
Total Pages: 242
Release: 2018-03-28
ISBN: 3319679325
Category: Medical
Language: EN, FR, DE, ES & NL

Resistance to Anti Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways Book Excerpt:

This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.

Molecular Medicine

Molecular Medicine
Author: Jens Kurreck,Cy Aaron Stein
Publsiher: John Wiley & Sons
Total Pages: 404
Release: 2016-02-16
ISBN: 3527331891
Category: HEALTH & FITNESS
Language: EN, FR, DE, ES & NL

Molecular Medicine Book Excerpt:

Easy to read, yet comprehensive, this is the perfect introduction into the molecular basis of disease and the novel treatment options that have become available. The authors, Jens Kurreck and Cy Stein, have both long-standing teaching experience on the subject, one from a biologist's angle, the other with a medical background. Together, they have produced a modern textbook for courses in Molecular Medicine that incorporates modules from immunology to signaling, from virology to gene therapy, and the latest development in personalized medicine.

Lung Cancer and Personalized Medicine

Lung Cancer and Personalized Medicine
Author: Aamir Ahmad,Shirish Gadgeel
Publsiher: Springer
Total Pages: 228
Release: 2015-12-14
ISBN: 3319242237
Category: Medical
Language: EN, FR, DE, ES & NL

Lung Cancer and Personalized Medicine Book Excerpt:

This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.