Tissue Engineering Stem Cells and Gene Therapies

Tissue Engineering  Stem Cells  and Gene Therapies
Author: Y. Murat Elçin
Publsiher: Springer Science & Business Media
Total Pages: 340
Release: 2012-12-06
ISBN: 146150063X
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Tissue Engineering Stem Cells and Gene Therapies Book Excerpt:

Recent years have seen an upsurge of significant interest in cell-based technologies. A range of productive and lively debate have taken place relating to tissue engineering, namely the construction of tissues and whole organs using molecularly-designed resorbable biomaterials to create tissue de novo, the potential use of human embryonic stem cells for transplantation and regenerative medicine, with similar potential for adult-derived stem cells, and gene therapy, in relation to cell transplantation. New findings in biomimetic materials, cell signalling pathways, extracellular matrix receptors and ligands, growth factors, and the human genome project, all present particularly motivating sources for the development of research in the evergrowing biomedical field. The purpose of this book is to stimulate further the work in biomedicine and to make the issues of related scientific disciplines accessible to a wider readership by characterising the current state of research in the biomedical field. The lectures and a selection of the presentations from BlOMED 200- th The 9 International Symposium on Biomedical Science and Technology, held in September 2002 in Turkey- constitute the basis for the volume. Tissue engineering, stem cells, cell and gene therapies were the major topics presented and discussed in the symposium. This book is intended to serve as an up-to-date synopsis of the major developments of our area through the work reflected in BlOMED 2002, though not covering all aspects of the topics, due to the natural restrictions within a volume of this kind.

Stem Cell and Gene Based Therapy

Stem Cell and Gene Based Therapy
Author: Alexander Battler,Jonathan Leor
Publsiher: Springer Science & Business Media
Total Pages: 422
Release: 2007-06-26
ISBN: 9781846286766
Category: Medical
Language: EN, FR, DE, ES & NL

Stem Cell and Gene Based Therapy Book Excerpt:

Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Emerging Trends in Cell and Gene Therapy

Emerging Trends in Cell and Gene Therapy
Author: Michael K. Danquah,Ram I. Mahato
Publsiher: Springer Science & Business Media
Total Pages: 705
Release: 2013-06-14
ISBN: 162703417X
Category: Science
Language: EN, FR, DE, ES & NL

Emerging Trends in Cell and Gene Therapy Book Excerpt:

Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies. Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills the vast unmet educational need and interest of both students and researchers in academia and industry. Main features of the book: · Biological aspects of stem cell sources, differentiation and engineering. · Application of microfluidics to study stem cell dynamics · Potential clinical application of stem cells and gene therapy to specific human disease. · Utilization of biomaterials and stem cells in regenerative medicine with particular emphasis on spinal cord repair, ligament and bone tissue engineering. · Biomimetic multiscale topography for cell alignment.

Engineering of Stem Cells

Engineering of Stem Cells
Author: Ulrich Martin
Publsiher: Springer
Total Pages: 239
Release: 2009-09-25
ISBN: 3540888063
Category: Science
Language: EN, FR, DE, ES & NL

Engineering of Stem Cells Book Excerpt:

I am very pleased to present this volume on engineering stem cells in Advances in Biochemical Engineering and Biotechnology. This volume stays abreast of recent developments in stem cell biology and the high expectations concerning the dev- opment of stem cell based regenerative therapies. Regenerative medicine is the focus of current biomedical research, with unique challenges related to scientific, technical and ethical issues of stem cell research, and the potential added value of connecting biomedicine with enabling techno- gies such as materials sciences, mechanical- and nano-engineering. Research activities in regenerative medicine include strategies in endogenous regeneration of injured or degenerated tissues by means of gene therapy or cell transplantation, as well as complex approaches to replace or reconstruct lost or malformed tissue structures, by applying tissue engineering approaches. In most cases, the speci- ized functional cell types of interest cannot be isolated from the diseased organ or expanded to a sufficient degree, and various stem and progenitor cell types rep- sent the only applicable cell source. In almost all cases, stem cells have to be engineered, sometimes for functional improvement, in many cases to produce large numbers of cells, and frequently to achieve efficient and specific differentiation in the cell type(s) of interest.

Stem Cell and Gene Therapy for Cardiovascular Disease

Stem Cell and Gene Therapy for Cardiovascular Disease
Author: Emerson C. Perin,Leslie W. Miller,Doris Taylor,James T. Willerson
Publsiher: Academic Press
Total Pages: 538
Release: 2015-08-21
ISBN: 0128018631
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cell and Gene Therapy for Cardiovascular Disease Book Excerpt:

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

Safety Ethics and Regulations

Safety  Ethics and Regulations
Author: Phuc Van Pham,Achim Rosemann
Publsiher: Springer
Total Pages: 327
Release: 2017-08-12
ISBN: 3319591657
Category: Science
Language: EN, FR, DE, ES & NL

Safety Ethics and Regulations Book Excerpt:

This invaluable resource discusses the saftey, ethics, and regulations of developing stem cell clinical applications. Each chapter is contributed by a preeminent scientist in the field and covers such topics as clinical safety of stem cell gene therapy, the patentability of hESC technologies, international guidelines, challenges to international stem cell clinical trials, worldwide regulations including in emerging markets like China and Taiwan. Saftey, Ethics, and Regulations and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Mesenchymal Stem Cell Mediated Gene Therapy for Bone Tissue Engineering and Regeneration

Mesenchymal Stem Cell Mediated Gene Therapy for Bone Tissue Engineering and Regeneration
Author: Gadi Turgeman
Publsiher: Unknown
Total Pages: 252
Release: 2004
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Mesenchymal Stem Cell Mediated Gene Therapy for Bone Tissue Engineering and Regeneration Book Excerpt:

Regenerative Medicine from Protocol to Patient

Regenerative Medicine   from Protocol to Patient
Author: Gustav Steinhoff
Publsiher: Springer
Total Pages: 369
Release: 2016-06-07
ISBN: 331928293X
Category: Science
Language: EN, FR, DE, ES & NL

Regenerative Medicine from Protocol to Patient Book Excerpt:

​Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 4 first gives a survey on the historical background of science and development of regenerative therapies. Ethical, preclinical and regulatory issues for the introduction of new regenerative therapies are depicted as the current background for clinical translation. The clinical chapters describe the state of development for medical science, technology application, and clinical translation for the nervous system, head, and respiratory system.

Regenerative Medicine from Protocol to Patient

Regenerative Medicine   from Protocol to Patient
Author: Gustav Steinhoff
Publsiher: Springer
Total Pages: 396
Release: 2016-06-14
ISBN: 3319283863
Category: Science
Language: EN, FR, DE, ES & NL

Regenerative Medicine from Protocol to Patient Book Excerpt:

​Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 5 contains clinical science and translation surveys on the circulatory system, visceral, musculoskeletal and skin. The state-of-the-art descriptions involve concepts for clinical diagnosis, stem cell and gene therapy, biomaterials for tissue replacement and pharmacological/biomolecule treatment strategies.

Stem Cell Transplantation

Stem Cell Transplantation
Author: Carlos López-Larrea,Antonio López Vázquez,Beatriz Suárez Álvarez
Publsiher: Springer Science & Business Media
Total Pages: 342
Release: 2012-03-28
ISBN: 1461420989
Category: Science
Language: EN, FR, DE, ES & NL

Stem Cell Transplantation Book Excerpt:

Organ transplantation has been the most important therapeutic advance in the last third of the 20th century. Its development has revolutionized medicine, as demonstrated by the fact that a large number of researchers in this field have been awarded Nobel Prizes. In the beginning of this century, we are witnessing with great expectations the emergence of a new field of medicine related to the arrival of a new player on the scene: “stem cells” and their potential use in regenerative medicine. This volume aims to cover important aspects of the various facets of organ transplantation and regenerative medicine, with leading specialists in these fields setting out their vision. We try to rigorously explain current and novel scientific research in these fields—areas which arouse great interest from society in general, due to their potential use in modern medicine for the treatment of a great number of diseases.

Stem Cells

Stem Cells
Author: Eapen Cherian,Cherian Eapen,G. Nandhini,Nandhini G,Kurian Anil
Publsiher: JP Medical Ltd
Total Pages: 116
Release: 2011-07
ISBN: 9789350250600
Category: Medical
Language: EN, FR, DE, ES & NL

Stem Cells Book Excerpt:

Beginning with a basic introduction to the field, this book provides a comprehensive review of the properties and potential uses of stem cells, including stem cells in tissue engineering, cancer, gene therapy and in dental tissues. Stem Cells compares two key types of mammalian stem cell - embryonic and adult. Different stem cell systems are discussed, as well as potential obstacles in the use of human stem cells.

Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine
Author: Johnny Huard,Freddie H. Fu
Publsiher: Springer Science & Business Media
Total Pages: 286
Release: 2013-03-11
ISBN: 1461221269
Category: Medical
Language: EN, FR, DE, ES & NL

Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine Book Excerpt:

This book has been written in response to the many physicians and scien tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.

Proceedings of 7th International Conference and Exhibition on Cell and Gene Therapy 2018

Proceedings of 7th International Conference and Exhibition on Cell and Gene Therapy 2018
Author: ConferenceSeries
Publsiher: ConferenceSeries
Total Pages: 83
Release: 2022
ISBN: 1928374650XXX
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Proceedings of 7th International Conference and Exhibition on Cell and Gene Therapy 2018 Book Excerpt:

March 15-16, 2018 London,UK Key Topics : Stem Cell Therapies, Cell Culture and Bioprocessing, Viral Gene Therapy, Gene and Cell Therapy for Rare & Common Diseases, Tissue Science & Regenerative Medicine, Molecular Basis of Epigenetics, Clinical Trials on Cell & Gene Therapy, Cell Science and Stem Cell Research, Bioengineering Therapeutics, Nano Therapy, Gene Editing Technology, Advanced Gene Therapeutics, Genetics & Genomic Medicine, Ethical Issues in Cell and Gene Therapy, Markets & Future Prospects for Cell & Gene Therapy, Cell Therapy, Gene Therapy, Cell Therapy of Cardiovascular Disorders, Cell Therapy for Neurological Disorders, Regulatory and Safety Aspects of Cell and Gene Therapy, Commercialization,

Adipose Stem Cells and Regenerative Medicine

Adipose Stem Cells and Regenerative Medicine
Author: Yves-Gerard Illouz,Aris Sterodimas
Publsiher: Springer Science & Business Media
Total Pages: 278
Release: 2011-09-07
ISBN: 9783642200120
Category: Medical
Language: EN, FR, DE, ES & NL

Adipose Stem Cells and Regenerative Medicine Book Excerpt:

The therapeutic potential of the use of adipose stem cells in regenerative medicine has been increasingly recognized, and in recent years concrete clinical benefits have accrued as these cells have been explored for a variety of applications. This readable and informative textbook tracks the progress that has been made in this fascinating new area of biomedicine. All aspects of the subject are considered, with particular attention to adipose cell biology, adipose tissue engineering strategies, and the diverse clinical applications of adipose stem cells. Funding issues, industrial approaches, regulatory challenges, and future directions are also examined. The two editors have vast experience in the field and have chosen leading experts from different countries to write on each topic. This book will excite the interest of all researchers, clinicians, and students wishing to gain an in-depth understanding of adipose stem cells and their flourishing role in regenerative medicine.

Cell Biology and Translational Medicine Volume 4

Cell Biology and Translational Medicine  Volume 4
Author: Kursad Turksen
Publsiher: Springer
Total Pages: 191
Release: 2019-01-08
ISBN: 3030104869
Category: Science
Language: EN, FR, DE, ES & NL

Cell Biology and Translational Medicine Volume 4 Book Excerpt:

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the fourth volume of a continuing series.

Principles of Regenerative Medicine

Principles of Regenerative Medicine
Author: Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Publsiher: Academic Press
Total Pages: 1202
Release: 2010-12-16
ISBN: 9780123814234
Category: Science
Language: EN, FR, DE, ES & NL

Principles of Regenerative Medicine Book Excerpt:

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches

Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches
Author: Hidezo Mori,Hikaru Matsuda
Publsiher: Springer Science & Business Media
Total Pages: 238
Release: 2006-06-18
ISBN: 4431273786
Category: Medical
Language: EN, FR, DE, ES & NL

Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches Book Excerpt:

The cardiovascular system transports oxygen and nutrients to all parts of the body; therefore, any impediment to this system through, for example, a circulatory disorder, represents a serious threat to organs, tissues, and cells. Obstructive diseases of vessels with a diameter of more than 1 mm can be treated by conventional surgical and interventional approaches; however, blockages in small vessels with a diameter of less than 1 mm cannot be treated by conventional methods. As a consequence, therapeutic ang- genesis and vasculogenesis for the treatment of ischemic diseases have been widely studied in the last decade. These methods may contribute to the re pair of intractable cardiovascular diseases with a main vascular involvement in the body's smallest vessels. In this book, Hikaru Matsuda and I have tried to summarize recent Japanese developments in the field of cardiovascular regeneration therapies using tissue engineering. The Ministry of Health, Labor, and Welfare of Japan has been encouraging the National Cardiovascular Center Research Institute to promote cardiovascular regeneration therapies using such ap proaches. Therefore, it is with the financial aid and support of research grants, such as that for Cardiovascular Disease (13C-1 and I6C-6), Health and Labor Sciences Research Grants (RHGTEFB-genome-005, RHGTEFB-saisei-003, and CRCD-junkanki-009) and a grant from NEDO of Japan, that significant progress has been possible.

Gene Therapy for Cartilage and Bone Tissue Engineering

Gene Therapy for Cartilage and Bone Tissue Engineering
Author: Yu-Chen Hu
Publsiher: Springer Science & Business Media
Total Pages: 89
Release: 2014-01-26
ISBN: 3642539238
Category: Technology & Engineering
Language: EN, FR, DE, ES & NL

Gene Therapy for Cartilage and Bone Tissue Engineering Book Excerpt:

"Gene Therapy for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering. It is intended for tissue engineers, cell therapists, regenerative medicine scientists and engineers, gene therapist and virologists. Dr. Yu-Chen Hu is a Distinguished Professor at the Department of Chemical Engineering, National Tsing Hua University and has received the Outstanding Research Award (National Science Council), Asia Research Award (Society of Chemical Engineers, Japan) and Professor Tsai-Teh Lai Award (Taiwan Institute of Chemical Engineers). He is also a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a member of the Tissue Engineering International & Regenerative Medicine Society (TERMIS)-Asia Pacific Council.

Gene Therapy in Reconstructive and Regenerative Surgery

Gene Therapy in Reconstructive and Regenerative Surgery
Author: Giorgio Giatsidis
Publsiher: Springer
Total Pages: 113
Release: 2018-08-02
ISBN: 3319789570
Category: Medical
Language: EN, FR, DE, ES & NL

Gene Therapy in Reconstructive and Regenerative Surgery Book Excerpt:

This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.

Methods of Tissue Engineering

Methods of Tissue Engineering
Author: Anthony Atala
Publsiher: Gulf Professional Publishing
Total Pages: 1285
Release: 2002
ISBN: 0124366368
Category: Medical
Language: EN, FR, DE, ES & NL

Methods of Tissue Engineering Book Excerpt:

This book will be a resource for the experienced tissue engineer, a starting point for the student, and a guidebook for the next generation of tissue engineers. Contained in one volume is a comprehensive reference that combines the tools, experimental protocols, detailed descriptions, and "know-how" for the successful engineering of tissues and organs. The practical information contained in the numerous protocols covers every area of tissue engineering and will prove essential to scientists working in this field. Contributions by leaders in the latest areas of research will also be of interest to biotechnological and pharmaceutical researchers. Key Features * Provides comprehensive protocols covering every area of tissue engineering, including polymer synthesis, cell culture, encapsulation, bioreactors, therapeutics, and the creation of tissues and organs; * Includes contributions by leaders in the latest areas of research, such as stem cells and fetal tissue engineering