Tuberculous Meningitis

Tuberculous Meningitis: Manual of Diagnosis and Therapy focuses on the most common and most lethal manifestation of tuberculosis of the central nervous system. It includes up-to-date reviews of the diagnosis, treatment, and management of tuberculous meningitis in adults and children. Extensive guidance is provided for the treatment of drug-sensitive and drug-resistant tuberculosis and tuberculous meningitis. Clinicians and researchers will find the beginning chapters on immunopathology and epidemiology of great use in their efforts to develop new strategies for the diagnosis and treatment of tuberculous meningitis. Written by international contributors from countries most affected by tuberculosis Describes clinical and neuroimaging features of tuberculous meningitis Examines laboratory methods for detecting Mycobacterium tuberculosis Reviews international and national guidelines for the treatment of tuberculosis and tuberculous meningitis

Tuberculous Meningitis: Manual of Diagnosis and Therapy focuses on the most common and most lethal manifestation of tuberculosis of the central nervous system. It includes up-to-date reviews of the diagnosis, treatment, and management of tuberculous meningitis in adults and children. Extensive guidance is provided for the treatment of drug-sensitive and drug-resistant tuberculosis and tuberculous meningitis. Clinicians and researchers will find the beginning chapters on immunopathology and epidemiology of great use in their efforts to develop new strategies for the diagnosis and treatment of tuberculous meningitis. Written by international contributors from countries most affected by tuberculosis Describes clinical and neuroimaging features of tuberculous meningitis Examines laboratory methods for detecting Mycobacterium tuberculosis Reviews international and national guidelines for the treatment of tuberculosis and tuberculous meningitis

Thoroughly revised and updated for its Sixth Edition, this classic work is the most comprehensive reference on diagnosis and treatment of neuro-ophthalmologic diseases. This edition has two new editors—Valérie Biousse, MD and John B. Kerrison, MD—and has been streamlined from five volumes into three tightly edited volumes with a sharper focus on patient management. Coverage includes major updates on genetics of diseases, new diagnostic techniques, and the newest treatment options. This third volume covers degenerative, metabolic, infectious, inflammatory, and demyelinating diseases. Volume 1 covers the visual sensory system, the autonomic nervous system, the ocular motor system, the eyelid, facial pain and headache, and nonorganic disease. Volume 2 covers tumors, the phacomatoses, and vascular disease.

Completely revised and updated, this comprehensive resource covers the epidemiology, pathogenesis, varied clinical manifestations, treatment and prevention of tuberculosis. All of the extra-pulmonary as well as pulmonary manifestations of tuberculosis are covered. Atypical mycobacterial infection is detailed. A special feature of this second edition is the new material on AIDS, which is now known to be complicated by tuberculosis infection.

"Collection of incunabula and early medical prints in the library of the Surgeon-general's office, U.S. Army": Ser. 3, v. 10, p. 1415-1436.

Now in its third edition, this essential and detailed guide provides wide-ranging support for those diagnosing, treating and assessing complex types of cerebrovascular diseases, in a high pressure, time-constrained environment. Authored by leading clinicians in the field of neurology, and supported by advanced in brain-mapping technologies, this cutting-edge manual provides physicians, neurologists and emergency practitioners at all levels with a vital commentary on those relatively uncommon types of cerebrovascular disease that can lead to patients suffering a stroke. This new edition offers chapter-by-chapter imaging findings, evaluation and management advice, alongside insights into new topics such as CARASIL, sickle cell disease, radiation-induced cerebrovascular disease and blue rubber bleb syndrome. Updated and thorough, the guide provides a clear presentation on the nature, diagnosis, and treatment of everyday symptoms, through to more specialised cases. Building upon existing experience, practitioners can confidently assess patient needs, and correctly diagnose symptoms first time.

At the beginning of the new millennium, it is opportune to raveling of the molecular pathways of impaired host - review what has been accomplished in the field of infec- fense mechanisms and the characterization of the genetic tious diseases during the last decades of the previous mutations involved, with the prospect of novel strategies century. The paradigm of the immunocompromised host for therapeutic interventions and possible corrective gene has taught much about the pathophysiology of infectious therapy. In this foreword, I will take a helicopter view of diseases, particularly with regard to immunological as- the various aspects of host defense mechanisms with pects of host defense. In the beginning, Robert Good special emphasis on genetic factors, because of their re- called immunodeficiency syndromes “experiments of na- vance for the course and outcome of infections. ture. ” In the 1960s and subsequent decades, the clinical During life, there exist phases of age-related c- and immunological aspects of immune deficiencies were promised immune functions. After birth there is a phys- studied and adequate treatment attempted. A reflection of logical immune deficiency because the production of an- these developments were the three successful meetings on bodies commences slowly upon contact of the neonate these topics in Veldhoven, The Netherlands (1980), Stir- with microorganisms and upon vaccination.

Meningitis and Encephalitis are associated with high rates of mortality and neurological sequelae. The differential diagnosis includes a wide spectrum of infectious and non-infectious etiologies, some requiring urgent therapy for survival. The current management challenges in patients with meningitis and encephalitis include a low sensitivity of meningeal signs, overutilization of unnecessary screening cranial imaging, delays in diagnosis of urgent treatable causes, a large proportion of unknown etiologies, low sensitivity of current microbiological techniques especially in the setting of previous antibiotic therapy, underutilization of available molecular diagnostic tests, and empiric antibiotic therapy and hospitalization for viral meningitis cases. Even though there are published guidelines, compliance with them is not optimal and physicians do not follow standardized algorithms in their empirical approach. As meningitis and encephalitis is associated with high rates of adverse clinical outcomes, prevention, when feasible is of upmost importance. Adherence to protocols to prevent health-care associated meningitis and ventriculitis are effective but compliance with them is not uniformly performed. This book seeks to improve outcomes for meningitis and encephalitis cases handled by physicians who may or may not be thoroughly trained for these challenges. The text introduces the current guidelines but also discusses the gaps that leave clinicians struggling to implement the most appropriate approaches for these particular neurological infections. Each chapter delivers the tools necessary to identify and adhere to the most appropriate diagnostic technique, management protocols, and prevention approach for each situation. All chapters conclude with discourse on future directions in research and quality improvement. Written by experts in infectious diseases, the book covers topics that are the most devastating, including healthcare-acquired infections, autoimmune encephalitis, and infections as they present in HIV patients. Meningitis and Encephalitis is a well-rounded resource for all medical professionals encountering these neurological syndromes, including infectious disease specialists, neurologists, primary care physicians, and immunologists.

Infections of the Nervous System aims to continue the legacy of its predecessor, Modern Trends in Neurology. Its goal is to produce annually a monograph on a topic in clinical neurology in which progress through research has brought about new concepts of patient management. This book is organized into 13 chapters. It highlights the areas or subjects in which significant advances have been made which also have relevance to the treatment of patients. It covers a number of important aspects of different infectious diseases of the nervous system including acute bacterial meningitis, tuberculosis of the nervous system, spirochaetal infections of the nervous system, and fungal diseases of the central nervous system. This book is intended for use by physicians who deal with the problems of neurological disorder on a daily basis, whether they are neurologists, neurologists in training, or those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

This book is a comprehensive guide to the diagnosis and management of both common and rare neurological disorders, for practising neurologists and trainees. Divided into twelve chapters, each section is dedicated to a subspecialty of neurology, including movement disorders, headache, epilepsy, neurotoxicology, stroke and more. Topics are presented with a broad overview and include recent advances in the field. Content is further enhanced by tables, clinical images, boxes and flow charts to assist learning. Key points Comprehensive guide to neurological disorders for clinicians and trainees Each section dedicated to a subspecialty of neurology Includes recent advances in the field Highly illustrated with tables, clinical images, boxes and flow charts

Meningitis is an uncommon but serious illness at any age, and during the first few weeks of life it poses a particular hazard with high mortality and a considerable risk to survivors of permanent damage to the developing brain. This book comprehensively reviews bacterial, fungal and viral forms of the illness. Epidemiology and comparisons of maternally and environmentally derived infections are included, along with a view of the developing brain and host defence mechanisms. A review of experimental bacterial meningitis is provided, together with a discussion of its relevance for clinical and laboratory diagnosis, and for antimicrobial and supportive management. Prospects for the future in terms of early diagnosis, management and prevention are also addressed. In its collation of material from such a wide range of literature sources, this is a vital reference for all clinicians with an interest in the problems of meningitis in early life.

This book is a practical guide to the diagnosis and management of both common and less common neurological disorders and diseases for clinicians and trainees. Divided into sixteen sections, each chapter presents a different condition providing a step by step approach from basic knowledge, history and examination, to key aspects of clinical diagnosis, investigations, and medical and surgical treatment. A complete chapter is dedicated to the effects of diabetes on the central and peripheral nervous system, and potential complications. The text is accompanied by clinical photographs and diagrams to enhance learning. Key points Practical guide to the diagnosis and management of neurological disorders and diseases Presented in step by step approach covering both common and less common conditions Complete chapter dedicated to effects and complications of diabetes on central nervous system Includes clinical photographs and diagrams to enhance learning

"Collection of incunabula and early medical prints in the library of the Surgeon-general's office, U.S. Army": Ser. 3, v. 10, p. 1415-1436.

Aminoff's Neurology and General Medicine is the standard and classic reference providing comprehensive coverage of the relationship between neurologic practice and general medicine. As neurologists are asked to consult on general medical conditions, this reference provides an authoritative tool linking general medical conditions to specific neurologic issues and disorders. This is also a valuable tool for the general practitioner seeking to understand the neurologic aspects of their medical practice. Completely revised with new chapters covering metastatic disease, bladder disease, psychogenic disorders, dementia, and pre-operative and post-operative care of patients with neurologic disorders, this new edition will again be the go-to reference for both neurologists and general practitioners. The standard authoritative reference detailing the relationship between neurology and general medicine 100% revised and updated with several new chapters Well illustrated, with most illustrations in full color

Examining meningitis mainly from a bacterial perspective, but also including an overview of viral, fungal and chronic meningitis, this book describes the anatomy of the meninges and clinical signs and symptoms of meningitis. Individual organisms that cause meningitis worldwide are dealt with in specific chapters, describing in detail how these pathogens interact with the human host at both a molecular and cellular level, providing a thorough understanding of bacterial virulence factors and host cell response.