Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics
Author: Shuai Li,John Hopper,Trygve Tollefsbol
Publsiher: Elsevier
Total Pages: 374
Release: 2021-08-30
ISBN: 0128209518
Category: Medical
Language: EN, FR, DE, ES & NL

Twin and Family Studies of Epigenetics Book Excerpt:

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics
Author: Shuai Li,John Hopper
Publsiher: Academic Press
Total Pages: 374
Release: 2021-08-31
ISBN: 0128209526
Category: Medical
Language: EN, FR, DE, ES & NL

Twin and Family Studies of Epigenetics Book Excerpt:

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

Twin Research for Everyone

Twin Research for Everyone
Author: Adam D. Tarnoki,David L. Tarnoki,Jennifer Harris,Nancy L. Segal
Publsiher: Academic Press
Total Pages: 740
Release: 2022-08-26
ISBN: 0128215151
Category: Medical
Language: EN, FR, DE, ES & NL

Twin Research for Everyone Book Excerpt:

Twin Research: Biology, Health, Epigenetics, and Psychology is a comprehensive, applied resource in twinning and twin studies that is grounded in the most impactful findings from twin research in recent years. While targeted to undergraduate and graduate students, this compendium will prove a valuable resource for scholars already familiar with twin studies, as well as those coming to the field for the first time. Here, more than forty experts across an array of disciplines examine twinning and twin research methodologies from the perspectives of biology, medicine, genetic and epigenetic influences, and neuroscience. Chapters provide clear instruction in both basic and advanced research methods, family and parenting aspects of twinning, twin studies as applied across various disease areas and medical specialties, genetic and epigenetic determinants of differentiation, and academic, neurological and cognitive development. The presentation of existing studies and methods instruction empowers students and researchers to apply twin-based research and advance new studies across a range of biomedical and behavioral fields, highlighting current research trends and future directions. Offers unique insights into twinning rates, mechanisms and factors surrounding twinship Provides clear instruction on both basic and advanced twin research methods and study design Features leading international experts in twin biology, genetics, health and psychology Examines findings from recent twin studies across a broad array of health and behavioral studies

The Medical Basis of Psychiatry

The Medical Basis of Psychiatry
Author: S. Hossein Fatemi,Paula J. Clayton
Publsiher: Springer
Total Pages: 1064
Release: 2016-03-17
ISBN: 1493925288
Category: Medical
Language: EN, FR, DE, ES & NL

The Medical Basis of Psychiatry Book Excerpt:

Four years have passed since the last edition (3rd) of this book was published. In the intervening years, several reviews of this book have provided highly encouraging remarks about the value of this book in transmitting information on classification and treatment of psychiatric disorders to the audience. We are proposing to revise all chapters with an eye on accuracy and ease of use, and this is an especially timely endeavor with the upcoming publication of the Diagnostic and Statistical Manual V. All the appropriate new information on biology, etiology, diagnosis and treatment of psychiatric disorders will be added to the current proposed edition. It is our goal to recruit the same authors (if possible) who contributed to the previous edition. While all chapters will be updated (see TOC), those marked by asterisks will be the most likely to undergo more revision. Psychiatry has emerged as a burgeoning scientific field with major advances in etiology and treatment of several disorders. Just as there was excitement in the anatomic advances that took place a hundred years ago when Emil Kraepelin and his collaborators took on the enormous task of classification of psychiatric disorders based on rational scientific thinking, new advances in genetics, biochemistry, neuroanatomy and pharmacotherapy of mental disorders have brought us even closer to a better understanding of complex disorders like schizophrenia, bipolar disorder, depression and even autism. The major goal of the previous edition of this classic book was to update the busy clinician, psychiatric resident and medical student with the most up-to-date information on etiology, diagnosis and treatment of psychiatric disorders. This goal remains the focus of the fourth edition of this book. In this updated and expanded edition, the reader will be provided with the most contemporary information and literature supported by a close survey of the field. This new edition of this classic title, with its focus on biologic and medical aspects of psychiatry, will continue to be of significant help to all interested in the scientific practice of psychiatry.

The Psychobiology of Transsexualism and Transgenderism A New View Based on Scientific Evidence

The Psychobiology of Transsexualism and Transgenderism  A New View Based on Scientific Evidence
Author: Thomas E. Bevan Ph.D.
Publsiher: ABC-CLIO
Total Pages: 257
Release: 2014-11-17
ISBN: 1440831270
Category: Health & Fitness
Language: EN, FR, DE, ES & NL

The Psychobiology of Transsexualism and Transgenderism A New View Based on Scientific Evidence Book Excerpt:

Written by a biopsychologist, this book describes and explains transsexualism and transgenderism (TSTG) from a scientific vantage point. • Provides an unprecedented comprehensive coverage of transsexual and transgender science • Enables readers ranging from the general public to medical professionals, experimental and clinical psychologists, and policymakers with a broad understanding of transsexualism and transgenderism (TSTG) based on available scientific knowledge • Underscores how the conventional wisdom regarding the causes of transsexualism and transgenderism is wrong, and that the causal factors supported by scientific evidence are genetics and epigenetics • Supplies a balanced depiction of transsexual transition as a process that has proven to generate positive results but involves some specific health risks • Explains how the biology of TSTG people is different from non-TSTG people

Developmental Human Behavioral Epigenetics

Developmental Human Behavioral Epigenetics
Author: Livio Provenzi,Rosario Montirosso
Publsiher: Academic Press
Total Pages: 188
Release: 2020-11-12
ISBN: 0128192631
Category: Science
Language: EN, FR, DE, ES & NL

Developmental Human Behavioral Epigenetics Book Excerpt:

Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy. Enables more effective study design and methods application in behavioral epigenetics research across human and animal models Examines findings in human behavioral epigenetics to-date Features contributions from leading international researchers in behavioral epigenetics

Epigenetics in Psychiatry

Epigenetics in Psychiatry
Author: Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publsiher: Academic Press
Total Pages: 846
Release: 2021-08-16
ISBN: 0128235780
Category: Science
Language: EN, FR, DE, ES & NL

Epigenetics in Psychiatry Book Excerpt:

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Psychology

Psychology
Author: Douglas A. Bernstein,Julie Ann Pooley,Lynne Cohen,Bethanie Gouldthorp,Stephen C. Provost,Jacquelyn Cranney,Louis A. Penner,Alison Clarke-Stewart,Edward J. Roy
Publsiher: Cengage AU
Total Pages: 940
Release: 2017-09-18
ISBN: 0170386309
Category: Ethnopsychology
Language: EN, FR, DE, ES & NL

Psychology Book Excerpt:

Make introductory psychology modern and accessible! Strike a balance between classic and contemporary topics and theory. The new edition of this text engages students with local ideas and examples, within the context of psychology as an international discipline. Rich cultural and indigenous coverage is integrated throughout the text, as well as new chapters, 'Indigenous psychology', and 'Culture and psychology'. There is also the continued, and unique focus throughout the text on graduate attributes for accreditation, careers in psychology and the professional discipline of psychology. Linkages features in the text knit together student understanding of psychology's sub-disciplines, and the research sections show the how and why of research. World class learning technology available with Bernstein includes CourseMate Express, and a new MindTap.

A Statistical Approach to Genetic Epidemiology

A Statistical Approach to Genetic Epidemiology
Author: Andreas Ziegler,Inke R. Kônig,Friedrich Pahlke
Publsiher: John Wiley & Sons
Total Pages: 522
Release: 2011-08-24
ISBN: 3527633669
Category: Science
Language: EN, FR, DE, ES & NL

A Statistical Approach to Genetic Epidemiology Book Excerpt:

This is the second edition of the successful textbook written by the prize-winning scientist Andreas Ziegler, former President of the German Chapter of the International Biometric Society, and Inke Konig, who has been teaching the subject over many years. The book gives a comprehensive introduction into the relevant statistical methods in genetic epidemiology. The second edition is thoroughly revised, partly rewritten and includes now chapters on segregation analysis, twin studies and estimation of heritability. The book is ideally suited for advanced students in epidemiology, genetics, statistics, bioinformatics and biomathematics. Like in the first edition the book contains many problems and solutions and it comes now optionally with an e-learning course created by Friedrich Pahlke. This e-learning course has been developed to complement the book. Both provide a unique support tool for teaching the subject.

Oxford Textbook of Rheumatoid Arthritis

Oxford Textbook of Rheumatoid Arthritis
Author: David L. Scott,James Galloway,Andrew Cope,Vibeke Strand
Publsiher: Oxford University Press, USA
Total Pages: 576
Release: 2020-05-12
ISBN: 0198831439
Category: Medical
Language: EN, FR, DE, ES & NL

Oxford Textbook of Rheumatoid Arthritis Book Excerpt:

The Oxford Textbook of Rheumatoid Arthritis covers all relevant aspects of the fisease, ranging from basic science, epidemiology, clinical and laboratory assessments, drug and non-drug treatments, and disease outcomes. Written by an international team of experts, it will be an invaluable resource for those involved with people with RA.

Human Epigenomics

Human Epigenomics
Author: Carsten Carlberg,Ferdinand Molnár
Publsiher: Springer
Total Pages: 223
Release: 2018-02-01
ISBN: 9811076146
Category: Medical
Language: EN, FR, DE, ES & NL

Human Epigenomics Book Excerpt:

The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a useful reference for individuals working in biomedicine.

What you need to know about Schizophrenia

What you need to know about Schizophrenia
Author: Romeo Vitelli
Publsiher: ABC-CLIO
Total Pages: 178
Release: 2021-11-30
ISBN: 1440875308
Category: Psychology
Language: EN, FR, DE, ES & NL

What you need to know about Schizophrenia Book Excerpt:

Schizophrenia is a mental disorder characterized by delusions, hallucinations, and disordered thoughts and behaviors. Although schizophrenia requires lifelong treatment, early intervention can help individuals effectively manage their symptoms. Even so, it can be a challenging condition to navigate for both the patient and their loved ones. What You Need to Know about Schizophrenia is part of Greenwood's Inside Diseases and Disorders series. This series profiles a variety of physical and psychological conditions, distilling and consolidating vast collections of scientific knowledge into concise, readable volumes. A list of "top 10" essential questions begins each book, providing quick-access answers to readers' most pressing concerns. The text follows a standardized, easy-to-navigate structure, with each chapter exploring a particular facet of the topic. In addition to covering such basics as causes, signs and symptoms, diagnosis, and treatment options, books in this series delve into issues that are less commonly addressed but still critically important, such as effects on loved ones and caregivers. Case illustrations highlight key themes discussed in the book and are accompanied by insightful analyses and recommendations.

Brain Behavior and Epigenetics

Brain  Behavior and Epigenetics
Author: Arturas Petronis,Jonathan Mill
Publsiher: Springer Science & Business Media
Total Pages: 320
Release: 2011-05-19
ISBN: 3642174264
Category: Medical
Language: EN, FR, DE, ES & NL

Brain Behavior and Epigenetics Book Excerpt:

Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.

Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders

Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders
Author: Elena Martín-García,Patrick E. Williams,Noèlia Fernàndez-Castillo
Publsiher: Frontiers Media SA
Total Pages: 135
Release: 2022-07-06
ISBN: 2889765156
Category: Science
Language: EN, FR, DE, ES & NL

Genetic and Epigenetic Mechanisms Underpinning Vulnerability to Developing Psychiatric Disorders Book Excerpt:

Pharmacogenomics

Pharmacogenomics
Author: Yui-Wing Francis Lam,Larisa H. Cavallari
Publsiher: Academic Press
Total Pages: 510
Release: 2013-02-12
ISBN: 0123983037
Category: Medical
Language: EN, FR, DE, ES & NL

Pharmacogenomics Book Excerpt:

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics-including academic, regulatory, economic, industry and medical-to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Stress and Epigenetics in Suicide

Stress and Epigenetics in Suicide
Author: Vsevolod Rozanov
Publsiher: Academic Press
Total Pages: 236
Release: 2017-02-13
ISBN: 0128052864
Category: Medical
Language: EN, FR, DE, ES & NL

Stress and Epigenetics in Suicide Book Excerpt:

Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built. It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions. This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention. Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment Integrates social, psychological, and existential influences, giving readers a better understanding of the interdisciplinary nature of suicide risk factors Presents future directions for suicide-prevention strategies that incorporate recent research on genomics and stress resilience

Elsevier s Integrated Review Genetics

Elsevier s Integrated Review Genetics
Author: Linda R. Adkison
Publsiher: Elsevier Health Sciences
Total Pages: 255
Release: 2011-07-27
ISBN: 0323074480
Category: Medical
Language: EN, FR, DE, ES & NL

Elsevier s Integrated Review Genetics Book Excerpt:

Rev. ed. of: Elsevier's integrated genetics / Linda R. Adkison, Michael D. Brown. c2007.

Autism

Autism
Author: Andrew W. Zimmerman
Publsiher: Springer Science & Business Media
Total Pages: 474
Release: 2008-10-08
ISBN: 9781603274890
Category: Medical
Language: EN, FR, DE, ES & NL

Autism Book Excerpt:

Creative thinking and collaborative scientific research have advanced our understanding of autism, and we are now beginning to synthesize the data into evidence and theories. Autism: Current Theories and Evidence presents current theories about autism and the evidence that supports them. The goal is to show how the scientific method is revealing the biological bases of this spectrum of disorders, thereby leading the way to their treatment and prevention using evidence-based medicine. This book has 20 chapters divided into 6 sections: Molecular and Clinical Genetics; Neurotransmitters and Cell Signaling; Endocrinology, Growth and Metabolism; Immunology, Maternal-Fetal Effects and Neuroinflammation; Neuroanatomy, Imaging and Neural networks; and Environmental Mechanisms and Models. The subjects cover a wide range of current scientific work in the field of autism, with strong and growing evidence to support them, and demonstrate both the breadth and depth of current autism research. The reader is encouraged to consider how theories and the scientific method, in the hands of these and other dedicated researchers, are leading to greater knowledge and continued progress in autism research.

A Life Course Approach to Healthy Ageing

A Life Course Approach to Healthy Ageing
Author: Yoav Ben-Shlomo
Publsiher: Oxford University Press
Total Pages: 282
Release: 2014-01
ISBN: 0199656517
Category: Medical
Language: EN, FR, DE, ES & NL

A Life Course Approach to Healthy Ageing Book Excerpt:

This title investigates the lifetime determinants of healthy ageing and their implications for policy and practice, bringing together authorities in ageing research and knowledge transfer from across the world.

New Oxford Textbook of Psychiatry

New Oxford Textbook of Psychiatry
Author: John R. Geddes,Nancy C. Andreasen
Publsiher: Oxford University Press, USA
Total Pages: 1504
Release: 2020-02-20
ISBN: 0198713002
Category: Medical
Language: EN, FR, DE, ES & NL

New Oxford Textbook of Psychiatry Book Excerpt:

Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has been updated throughout to include the most recent versions of the two main classification systems---the DSM-5 and the ICD-11---used throughout the world for the diagnosis of mental disorders. In the years since publication of the first edition, many new and exciting discoveries have occurred in the biological sciences, which are having a major impact on how we study and practise psychiatry. In addition, psychiatry has fostered closer ties with philosophy, and these are leading to healthy discussions about how we should diagnose and treat mental illness. This new edition recognises these and other developments. Throughout, accounts of clinical practice are linked to the underlying science, and to the evidence for the efficacy of treatments. Physical and psychological treatments, including psychodynamic approaches, are covered in depth. The history of psychiatry, ethics, public health aspects, and public attitudes to psychiatry and to patients are all given due attention.