Vaccine Cell Substrates 2004

Author by : Rebecca Sheets
Languange : en
Publisher by : S Karger Ag
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Description : This publication comprises the proceedings of the Vaccine Cell Substrates 2004 conference. The purpose of this conference was to review current data and progress in the field of cell substrates, discuss the continued use of existing tests and the appropriateness of new ones at this time, and develop consensus recommendations on how to address these issues, by either recommending implementation or identifying research gaps that preclude decision-making. Scientific topics covered oncogenicity of cellular components, both latent viruses and cellular DNA, viral adventitious agent test methods, level of assurance provided by the current tests, bovine (and porcine) viruses in (primarily) bovine-derived raw materials, and bovine spongiform encephalopathy agents as potential contaminants of cell substrates. Also presented were tests that ensure the safety and quality of novel vaccine cell substrates for investigational vaccine production. Academia, regulators, the vaccine industry and the testing industry developing, regulating or testing viral vaccines will greatly benefit from the wealth of new findings.


Towards The Elimination Of Rabies In Eurasia

Author by : Betty Dodet
Languange : en
Publisher by : S Karger Ag
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Description : This volume presents the proceedings of the second conference on rabies organized by the World Organisation for Animal Health in collaboration with the World Health Organization and the European Union in May 2007. Up-to-date information on rabies epidemiology in humans and animals throughout Europe, The Middle East and Asia, and the most recent data on rabies virus and its structure, as well as the basic mechanisms of rabies infection are included here. Experts in the field present their experience and opinions on the prevention and control of rabies in dogs, wildlife including bats, and the most recent developments in rabies prevention and management in humans. Further presentations address advances in technology, diagnosis and vaccine development. To conclude, resolutions and recommendations are given in English, French and Russian for the elimination of rabies not only in Europe and Asia, but also the rest of the world. This book is highly valuable to regulatory veterinary services, public health services, medical and veterinary practitioners, scientists and researchers interested in combating this neglected disease, which kills more than 50,000 persons annually, mainly children. Rabies elimination is at hand, through a 'One Health' strategic collaboration between veterinary and human health authorities, political will and community involvement, and application of the knowledge gained from this volume.


Oie Fao International Scientific Conference On Avian Influenza

Author by : Alejandro Schudel
Languange : en
Publisher by : S Karger Ag
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Description : This monograph comprises the proceedings of the International Conference on Avian Influenza held in Paris, France, in April 2005. Discussed were new scientific discoveries in the domain of avian influenza (AI), with special emphasis on the highly pathogenic avian influenza (HPAI). It provides important up-to-date information on the virology, epidemiology and molecular biology as well as the history of episodes of avian influenza in different parts of the world and their consequences. The publication aims at making recommendations to compare and improve the international procedures and standards related to the identification, prevention, control and elimination of AI epizootics as they are a threat to the livelihood of farmers, especially in developing countries, to public health as well as to national economies. Chief veterinary officers, animal health regulatory officials, veterinarians, poultry-raising associations, consumer associations, specialised journalists and all those who need to understand and control AI episodes will benefit from reading this book.


Vaccines And Diagnostics For Transboundary Animal Diseases

Author by : J.A. Roth
Languange : en
Publisher by : Karger Medical and Scientific Publishers
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Description : Transboundary animal diseases (TADs) are a major threat to livestock. They are highly contagious or transmissible, and they have the potential to cause high morbidity and mortality in both susceptible animal populations and humans. In addition, not only are TADs detrimental to national economies, they are also a serious threat to world food security. This volume presents the proceedings of an international workshop on Vaccines and Diagnostics for Transboundary Animal Diseases that was held in Ames (Iowa, USA) in 2012. Experts and scientists from academia, industry and government reviewed the current status of vaccines and diagnostics for high priority TADs, decision-making and regulatory processes for veterinary biologics, and the roles and responsibilities of government agencies. The discussions also addressed achievements and gaps in vaccine and diagnostics development for 11 important TADs as well as the translation of research findings into licensed novel vaccines and diagnostics for high-priority TADs.


Animal Genomics For Animal Health

Author by : Marie-Hélène Pinard
Languange : en
Publisher by : Karger Medical and Scientific Publishers
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Total Read : 96
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Description : "It includes a review of the state of the art in animal genomics and its applications to animal health. The contributions describe the new tools available, such as HapMaps for chicken and cattle, and show how the understanding of gene structure and function can be successfully applied to delineate the molecular mechanisms of disease and determine complex phenotypes associated with health traits. A critical evaluation of future needs and future applications of animal genomics is also presented. The integration of animal genomics in animal health research is likely to revolutionize the way scientists approach the challenges of discovering highly effective drugs and vaccines for animal diseases."--BOOK JACKET.


Index Medicus

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New Diagnostic Technology

Author by : Philippe Vannier
Languange : en
Publisher by : S. Karger AG (Switzerland)
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Total Read : 87
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Description : Technological advances have resulted in the development of several new biochemistry-based test procedures such as DNA micro-arrays, rapid sequencing and multiple applications of polymerase chain reaction. The limitations of such tests and the problems of standardization and validation related to their use for the detection of agents and toxins, diagnosis of human and animal diseases, and quality control of human and veterinary biological products must be considered. Practical examples of the use of these new technologies, but also the difficulties, limits and uncertainties encountered in their application need to be shared. This volume presents the proceedings of a conference in Saint-Malo, France, held to facilitate discussion between government authorities, industry, scientists and other users of these new techniques. Information on the principles of these novel methods, the need for standardization and validation, applications in diagnosis and surveillance, certainties and uncertainties in agent or toxin identification as well as examples of quality control of human and veterinary biological products were addressed. Conclusions and recommendations concerning the development and standardization of these new technologies were developed by the participants and are published in these proceedings. Professionals involved in biological standardization, diagnosis, and human and animal health programs should find this to be a very valuable book.


Vaccination

Author by : Betty Dodet
Languange : en
Publisher by : S Karger Ag
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Description : The international community is confronted with a crisis caused by the unprecedented global spread of highly pathogenic avian influenza and its consequent scientific, economic, political, social and ethical challenges. Control strategies based only on the application of sanitary measures and the culling of animals that are infected or suspected of being infected have proven insufficient to avoid the propagation of infection. The OIE, together with the FAO, recommend the strategic use of poultry vaccination in certain situations as part of an overall integrated strategy to control the disease. This volume presents the proceedings of a scientific conference co-organized by the OIE, FAO and the Istituto Zooprofilattico Sperimentale delle Venezie with the support of the European Commission. The conference brought together scientists, representatives of government authorities, industry and other stakeholders to review current methods and recent experiences in the use of vaccination as a means to control and prevent losses due to avian influenza. They also scrutinized international standards and regulations for vaccination and considered the implementation of vaccination programmes. The proceedings include presentations on the experiences made in various parts of the world and the challenges and constraints faced by developing countries in implementing effective vaccination campaigns. Other contributions provide guidance to decision makers concerned with planning vaccination campaigns and up-to-date information on developments in avian influenza vaccines, their efficacy, their performance in different avian species and on strategies of differentiating infected from vaccinated animals as well as their application.


First International Conference Of The Oie Reference Laboratories And Collaborating Centres Florianopolis Brazil 3 5 December 2006

Author by : Michel Lombard
Languange : en
Publisher by : S Karger Ag
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Description : The 'OIE Global Network' of Reference Laboratories and Collaborating Centres is a key resource for the early and accurate diagnosis of animal disease pathogens and information pertaining to them. It provides expert support with the supply of science-based international reagents as well as the development of standards and guidelines for animal welfare and the food safety aspects of animal production, and recommendations for the prevention, detection and control of diseases such as zoonoses. The first international meeting of experts from 'OIE Reference Laboratories and Collaborating Centres' addressed the updating and setting of standards for methodologies in the fields of diagnostics, vaccine quality and biosecurity; the improvement of methods for internet networking, and the building of closer links between existing Reference Laboratories, Collaborating Centres and national and private veterinary laboratories. It demonstrated the need for OIE institutions to support developing and in-transition countries in facing current challenges and new threats linked to globalization and climate change through twinning, capacity building, and training programs.


Advances In Transfusion Safety

Author by : Elizabeth M. Dax
Languange : en
Publisher by : S Karger Ag
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Description : Improving the safety for blood and blood product transfusion It is amazing that in the first years of the 21st century there are insufficient blood supplies and that some supplies are unsafe in certain areas of the world. Regulations and codes call for continuous improvement in processes and attitudes to assure safety everywhere. To that end nearly 200 transfusionists and their colleagues gathered in Sydney in October 2005 to conduct a marathon symposium on methods and advances made towards achieving universal safety for blood and blood product transfusion. Sponsors of the latest products joined in to support this extraordinary meeting of information and ideas. Advances in transfusion safety were put forward from all areas of the blood transfusion process, including establishment of services, donor selection, infections that may affect donors, safe testing, risk and safety assessment, the roles of government and regulation, the use of blood and its products as well as the need for effective communication. The resulting papers from internationally renowned experts are published in these proceedings.


Vaccinology

Author by : Gregg N. Milligan
Languange : en
Publisher by : John Wiley & Sons
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Description : Vaccinology: An Essential Guide outlines in a clear,practical format the entire vaccine development process, fromconceptualization and basic immunological principles through toclinical testing and licensing of vaccines. With anoutstanding introduction to the history and practice ofvaccinology, it also guides the reader through the basic sciencerelating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economicand geographical issues that drive vaccine development and trials,it also presents vaccine delivery strategies, novel vaccineplatforms (including experimental vaccines and pathogens), antigendevelopment and selection, vaccine modelling, and the developmentof vaccines against emerging pathogens and agents of bioterror.There are also sections devoted to veterinary vaccines andassociated regulatory processes. Vaccinology: An Essential Guide is a perfect tool fordesigned for undergraduate and graduate microbiologists andimmunologists, as well as residents, fellows and trainees ofinfectious disease and vaccinology. It is also suitable for allthose involved in designing and conducting clinical vaccine trials,and is the ideal companion to the larger reference bookVaccinology: Principles and Practice.


Vaccine Development And Manufacturing

Author by : Emily P. Wen
Languange : en
Publisher by : John Wiley & Sons
Format Available : PDF, ePub, Mobi
Total Read : 14
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Description : Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market


New Concepts Of Antiviral Therapy

Author by : Elke Bogner
Languange : en
Publisher by : Springer
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Total Read : 75
Total Download : 265
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Description : Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.


The Journal Of Immunology

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State Of The Art Analytical Methods For The Characterization Of Biological Products And Assessment Of Comparability

Author by : Anthony R. Mire-Sluis
Languange : en
Publisher by : S Karger Ag
Format Available : PDF, ePub, Mobi
Total Read : 79
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File Size : 41,6 Mb
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Description : With the latest advances in analytical technologies, most biological products can now be extensively characterized in terms of their identity, heterogeneity and impurity profile. The currently available analytical methods (both physicochemical and biological) can characterize the primary, secondary and to some extent, the higher order structure of proteins. The sensitivity and selectivity of these methods allow for the identification and characterization not only of the desired protein component, but also many product-related substances and impurities as well as process-related impurities present in the drug preparations. Using an appropriate selection of analytical tools, it may be possible to demonstrate physicochemical and functional comparability between protein products manufactured before and after a manufacturing change or during product development. However, the extent of demonstrable comparability depends on the tests used, on the nature of the product and on the basic understanding of structure-function relationships. Assessment of immunogenicity is also a critical component of product characterization and is highly dependent on the types of assays used.


New Scientist

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Options For The Control Of Influenza V

Author by : Yoshihiro Kawaoka
Languange : en
Publisher by : Elsevier Science Health Science Division
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Total Read : 23
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Description : As researchers unravelled the mysteries of these new viruses, drug companies navigated new antiviral therapies designed to treat and prevent influenza through clinical trials.The continual development of new antivirals and control measures underscores not only the significance of influenza, but highlights options for the control of influenza


Handbook Of Cancer Vaccines

Author by : Michael A. Morse
Languange : en
Publisher by : Springer Science & Business Media
Format Available : PDF, ePub, Mobi
Total Read : 22
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Description : An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.


Weapons Of Mass Destruction And Terrorism

Author by : Alan O'Day
Languange : en
Publisher by : Ashgate Pub Limited
Format Available : PDF, ePub, Mobi
Total Read : 96
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Description : The twenty-nine articles explore the issue of WMD and key questions raised about terrorism, its definition, objects, motivation, whether there is a different species of it emerging in the aftermath of the close of the Cold War, preparedness and the means of prevention.The conventional, low-technology terrorism of the past has exercised a social and political impact far out of proportion with the casualties it has caused. The massive, indiscriminate destruction caused by an act of WMD terrorism similarly would have disproportionate social, political, economic and strategic effects.


Arbovirus Encephalitis Advances In Research And Treatment 2013 Edition

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Publisher by : ScholarlyEditions
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Description : Arbovirus Encephalitis—Advances in Research and Treatment: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Arbovirus Encephalitis—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Arbovirus Encephalitis—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.


Technical Report Series

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Genetics Abstracts

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Total Read : 53
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Nature

Author by : Sir Norman Lockyer
Languange : en
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Total Read : 24
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Wiley Encyclopedia Of Chemical Biology Volume 2

Author by : Tadhg P. Begley
Languange : en
Publisher by : Wiley-Blackwell
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Total Read : 21
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Description : The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.


Anticancer Research

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Description :