Practical Surgical Neuropathology

Practical Surgical Neuropathology
Author: Arie Perry,Daniel J. Brat
Publsiher: Elsevier Health Sciences
Total Pages: 654
Release: 2010-01-01
ISBN: 0443069824
Category: Medical
Language: EN, FR, DE, ES & NL

Practical Surgical Neuropathology Book Excerpt:

Practical Surgical Neuropathy-a volume in the new Pattern Recognition series- offers you a practical guide to solving the problems you encounter in the surgical reporting room. Drs. Arie Perry and Daniel J. Brat present diagnoses according to a pattern-based organization that guides you from a histological pattern, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Lavish illustrations capture key neuropathological patterns for a full range of common and rare conditions, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. No other single source delivers the practical, hands-on information you need to solve even the toughest diagnostic challenges in neuropathology. Includes fully searchable access to the text online at expertconsult.com, along with an image bank of over 1430 downloadable images and tables. Provides all the information essential for completing a sign-out report: clinical findings, pathologic findings, diagnosis, treatment, and prognosis. Illustrates key pathologic and clinical aspects of disease entities through over 1430 superb, high-quality full-color images that help you evaluate and interpret biopsy samples. Presents a team of internationally recognized experts for authoritative and up-to-date information from leading diagnosticians in neuropathology. Features a user-friendly design with patterns color-coded to specific entities in the table of context and text and key points summarized in tables, charts, and graphs so you can quickly and easily find what you are looking for. Directs you to the chapter and specific page number of the in-depth diagnostic guidance you need through a unique, pattern-based visual index at the beginning of the book. Details key diagnostic features associated with rare and esoteric conditions in a visual encyclopedia with distinctive findings and artifacts for unusual patterns at the end of the book. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Molecular Pathology of Nervous System Tumors

Molecular Pathology of Nervous System Tumors
Author: Matthias A. Karajannis,David Zagzag
Publsiher: Springer
Total Pages: 247
Release: 2014-11-21
ISBN: 1493918303
Category: Medical
Language: EN, FR, DE, ES & NL

Molecular Pathology of Nervous System Tumors Book Excerpt:

This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field. Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.

Diagnostic Histopathology of Tumors E Book

Diagnostic Histopathology of Tumors E Book
Author: Christopher D. M. Fletcher
Publsiher: Elsevier Health Sciences
Total Pages: 2440
Release: 2019-12-10
ISBN: 0323636136
Category: Medical
Language: EN, FR, DE, ES & NL

Diagnostic Histopathology of Tumors E Book Book Excerpt:

Known for its clear writing style, easy-to-navigate format, and authoritative coverage of tumor pathology, Dr. Christopher Fletcher’s Diagnostic Histopathology of Tumors, 5th Edition, remains your go-to source for accurate, efficient evaluation and interpretation of histopathology specimens. This highly regarded reference provides superbly illustrated information on pathogenesis, diagnostic criteria, molecular/cytogenetic findings, and prognosis on the neoplastic diseases most likely to be encountered by general surgical pathologists, and helps you stay current with the latest diagnostic tumor markers to assist in daily sign-out. Discusses the latest developments in immunohistochemistry, molecular genetics, targeted therapy/personalized medicine, and prognostic/predictive markers to assist in the diagnosis of the complete range of neoplastic entities. Includes coverage of newly described variants and new histologic entities. Covers all modern diagnostic techniques while retaining a strong emphasis on morphologic diagnosis, which remains the cornerstone of diagnosis for most lesions. Features thousands of high-quality photographs, photomicrographs, and artwork throughout. Incorporates the latest TNM and WHO classification and staging systems. Contains diagnostic flow charts, correlations of gross appearances to microscopic findings, and differential diagnosis tables for better recognition and evaluation of similar-looking entities. Shares the knowledge and expertise of internationally renowned experts in tumor pathology, including Dr. Christopher Fletcher, as well as numerous global authorities in the field.

Oncology of CNS Tumors

Oncology of CNS Tumors
Author: Jörg-Christian Tonn,Manfred Westphal,J. T. Rutka
Publsiher: Springer Science & Business Media
Total Pages: 793
Release: 2010-02-03
ISBN: 3642028748
Category: Medical
Language: EN, FR, DE, ES & NL

Oncology of CNS Tumors Book Excerpt:

Knowledge about the etiology and diagnosis as well as treatment concepts of neu- oncologic diseases is rapidly growing. This turnover of knowledge makes it dif? cult for the physician engaged in the treatment to keep up to date with current therapies. This book sets out to close the gap and pursues several innovative concepts. As a comprehensive text on neuro-oncology, its chapters are interconnected, but at the same time some chapters or subdivisions are so thoroughly assembled that the whole volume gives the impression of several books combined into one. Neuropathology is treated in an extensive and clearly structured section. The int- ested reader ? nds for each tumor entity the latest well-referenced consensus rega- ing histologic and molecular pathology. Through this “book-in-the-book” concept, information on neuropathology is readily at hand in a concise form and without ov- loading the single chapters. Pediatric neuro-oncology differs in many entities from tumors in adult patients; also, certain tumors of the CNS are typically or mainly found only in the child. Therefore, pediatric neuro-oncology was granted its own, book-like section. Tumor entities that are treated differently in children and adults are included both in the pediatric neuro-oncology section and in the general section. Entities that typically occur only in the child and adolescent are found in the pediatric section in order to avoid redundancies.

Pediatric Central Nervous System Tumors State of the Art and Debated Aspects

Pediatric Central Nervous System Tumors  State of the Art and Debated Aspects
Author: Angela Mastronuzzi,Andrea Carai,Elisabetta Ferretti,Evelina Miele
Publsiher: Frontiers Media SA
Total Pages: 84
Release: 2020-04-17
ISBN: 288963664X
Category: Electronic Book
Language: EN, FR, DE, ES & NL

Pediatric Central Nervous System Tumors State of the Art and Debated Aspects Book Excerpt:

Principles of Neurological Surgery

Principles of Neurological Surgery
Author: Richard G. Ellenbogen,Saleem I. Abdulrauf,Laligam N. Sekhar
Publsiher: Elsevier Health Sciences
Total Pages: 998
Release: 2012-01-01
ISBN: 1437707017
Category: Medical
Language: EN, FR, DE, ES & NL

Principles of Neurological Surgery Book Excerpt:

Rev. ed. of: Principles of neurosurgery / edited by Setti S. Rengachary, Richard G. Ellenbogen. 2nd ed. 2005.

Principles of Neurological Surgery E Book

Principles of Neurological Surgery E Book
Author: Richard G. Ellenbogen,Saleem I. Abdulrauf,Laligam N Sekhar
Publsiher: Elsevier Health Sciences
Total Pages: 997
Release: 2012-03-13
ISBN: 1455727679
Category: Medical
Language: EN, FR, DE, ES & NL

Principles of Neurological Surgery E Book Book Excerpt:

Principles of Neurosurgery, by Drs. Richard G. Ellenbogen, Saleem I. Abdulrauf and Laligam N Sekhar, provides a broad overview of neurosurgery ideal for anyone considering or training in this specialty. From general principles to specific techniques, it equips you with the perspectives and skills you need to succeed. Comprehensive without being encyclopedic, this new edition familiarizes you with the latest advances in the field—neuroimaging, the medical and surgical treatment of epilepsy, minimally invasive techniques, and new techniques in position and incisions—and shows you how to perform key procedures via an online library of surgical videos at www.expertconsult.com. No other source does such an effective job of preparing you for this challenging field! Get comprehensive coverage of neurosurgery, including pre- and post- operative patient care, neuroradiology, pediatric neurosurgery, neurovascular surgery, trauma surgery, spine surgery, oncology, pituitary adenomas, cranial base neurosurgery, image-guided neurosurgery, treatment of pain, epilepsy surgery, and much more. Gain a clear visual understanding from over 1,200 outstanding illustrations—half in full color—including many superb clinical and operative photographs, surgical line drawings, and at-a-glance tables. Apply best practices in neuroimaging techniques, minimally invasive surgery, epilepsy surgery, and pediatric neurosurgery. Master key procedures by watching experts perform them in a video library online at www.expertconsult.com, where you can also access the fully searchable text, an image gallery, and links to PubMed. Keep up with recent advances in neurosurgery with fully revised content covering neuroimaging, the medical and surgical treatment of epilepsy, minimally invasive techniques, new techniques in position and incisions, deep brain stimulation, cerebral revascularization, and treatment strategies for traumatic brain injury in soldiers. Apply the latest guidance from new chapters on Cerebral Revascularization, Principles of Modern Neuroimaging, Principles of Operative Positioning, Pediatric Stroke and Moya-Moya, Anomalies of Craniovertebral Junction, and Degenerative Spine Disease. Tap into truly global perspectives with an international team of contributors led by Drs. Richard G. Ellenbogen and Saleem I. Abdulrauf. Find information quickly and easily thanks to a full-color layout and numerous detailed illustrations.

Tumors of the Central Nervous System Volume 10

Tumors of the Central Nervous System  Volume 10
Author: M.A. Hayat
Publsiher: Springer Science & Business Media
Total Pages: 364
Release: 2012-12-22
ISBN: 940075681X
Category: Medical
Language: EN, FR, DE, ES & NL

Tumors of the Central Nervous System Volume 10 Book Excerpt:

Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors. As with the previous volumes in the series, this latest work addresses a central imperative in cancer research—the need to standardize classifications, written definitions and investigative guidelines in order to achieve a measure of shared objectivity among academics engaged in one of the most important medical endeavors of our era. It brings together the very latest work by oncologists, neurosurgeons, physicians, research scientists, and pathologists, providing the medical community with a wealth of data and results that, taken together, will advance the cause of cancer research. The volume synthesizes work on diagnosis, drug development, and therapeutic approaches that are typically scattered in a variety of journals and books. It features promising recent work in applying molecular genetics to clinical practice and evidence-based therapy, covering molecular profiling of tumors as well as a number of surgical treatments such as resection and radiosurgery. Together with its counterpart publications, it represents a much-needed central resource that will inform and guide future research efforts.

Pediatric Cancer Volume 4

Pediatric Cancer  Volume 4
Author: M.A. Hayat
Publsiher: Springer Science & Business Media
Total Pages: 346
Release: 2013-05-29
ISBN: 9400765916
Category: Medical
Language: EN, FR, DE, ES & NL

Pediatric Cancer Volume 4 Book Excerpt:

This entry in the series Pediatric Cancer offers comprehensive information on a variety of cancers, concentrating on brain tumors, the most common solid tumors and the leading cause of cancer-related mortality in children. The contents are organized in seven sections: Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors. Coverage includes pediatric medulloblastoma, and treatments including craniospinal radiation followed by adjuvant chemotherapy. The contributors explain diagnosis and chemotherapy of children with acute lymphoblastic leukemia, and diagnosis of bone marrow involvement in pediatric lymphoma patients. Ewing’s sarcoma, a highly malignant connective tissue neoplasm formed by the proliferation of mesenchymal cells, receives extensive coverage, including targeting of molecular pathways and chemotherapy and surgical treatment. The roles of apoptotic genes, MYCN gene, MDM2, and SNP309, P13K inhibitors, alternative splicing and microRNAs, activated leukocyte cell adhesion molecule and inhibition by alu-like RNA in neuroblastoma are discussed in detail. The book explores the molecular genetics, diagnosis, prognosis and therapy of the atypical teratoid/rhabdoid tumor (AT/RT). Among the most common malignant neoplasms in children, AT/RT exhibits similarities with other CNS tumors, which can lead to misclassification, as pointed out in the book. The contributors discuss diagnosis of AT/RT type using imaging technology, and describe new strategies, including intensive multimodal therapy and high dose chemotherapy with autologous stem cell transplantation that have shown improved outcomes. Coverage of therapies includes total resection followed by aggressive chemotherapy and radiation. Discussion includes diagnosis and treatment of other pediatric tumors including adrenocortical tumors, supratentorial primitive neuroectodermal tumors, giant midline tumors, gastrointestinal stromal tumors, ependymomas and intramedullary cavernoma. Pediatric Cancer: Diagnosis, Therapy and Prognosis, Volume 4 includes contributions by ninety-one contributors - oncologists, neurosurgeons, physicians, research scientists and pathologists - representing thirteen countries. The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological Sciences at Kean University, Union, New Jersey, USA.

Encyclopedia of Cancer

Encyclopedia of Cancer
Author: Anonim
Publsiher: Academic Press
Total Pages: 1841
Release: 2018-10-12
ISBN: 0128124857
Category: Medical
Language: EN, FR, DE, ES & NL

Encyclopedia of Cancer Book Excerpt:

Encyclopedia of Cancer, Third Edition provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented. Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health

Surgery of Cerebellopontine Lesions

Surgery of Cerebellopontine Lesions
Author: Madjid Samii,Venelin Gerganov
Publsiher: Springer Science & Business Media
Total Pages: 885
Release: 2013-03-27
ISBN: 364235422X
Category: Medical
Language: EN, FR, DE, ES & NL

Surgery of Cerebellopontine Lesions Book Excerpt:

This book covers the entire spectrum of cerebellopontine angle lesions, from the most common to the rarest. All aspects are considered, including biological and radiological characteristics, neurological presentation, diagnosis, treatment options and follow-up care. The main focus, however, is on surgical management, which is presented in detail with the aid of numerous figures and images documenting technical particularities. Emphasis is placed on an individualized approach tailored to the particular tumor type and extension pattern. Both novice and experienced surgeons will find the book to be an invaluable source of information and guidance. It will enable neurosurgeons in the initial years of training to understand and become familiar with the main steps in surgical management while simultaneously providing their senior colleagues with details and technical tips that will help to improve treatment results.

Brain Tumors E Book

Brain Tumors E Book
Author: Andrew H. Kaye,Edward R. Laws Jr
Publsiher: Elsevier Health Sciences
Total Pages: 931
Release: 2011-12-06
ISBN: 0702048186
Category: Medical
Language: EN, FR, DE, ES & NL

Brain Tumors E Book Book Excerpt:

Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. Benefit from the knowledge and experience of Drs. Andrew H. Kaye and Edward R. Laws, globally recognized experts in the field of neurosurgery, as well as many other world authorities.

Tumors of the Spinal Canal

Tumors of the Spinal Canal
Author: Simon Hanft,Paul C. McCormick
Publsiher: Springer Nature
Total Pages: 205
Release: 2020-11-13
ISBN: 3030550966
Category: Medical
Language: EN, FR, DE, ES & NL

Tumors of the Spinal Canal Book Excerpt:

This book presents a focused, case-oriented approach to a specific disease entity: tumors located within the spinal canal. Each tumor type constitutes its own chapter and additional chapters focus on more novel trends in the field, such as radiosurgery and minimally invasive surgical techniques. In each chapter, the authors provide expert opinions on preoperative goals, intraoperative techniques and decision-making, and postoperative paradigms, including surveillance guidelines and thresholds for initiating adjuvant therapy. The management of intradural tumors has become increasingly interdisciplinary, and one of the major goals of this text is to familiarize the treating neurosurgeon with the latest advances in both operative and non-operative strategies. The text seeks to answer two questions: 1) what are the detailed surgical steps taken by these neurosurgeons to ensure safe maximal resection of these tumors? and 2) in cases of residual and recurrent disease, what are the most effective management options? Consensus regarding definitive management remains difficult to reach given the overall rarity of these tumors. Tumors of the Spinal Canal is ultimately a practical reference drawn from the experiences of its individual authors, a compendium of surgical pearls, pitfalls, and preferences, all steeped in the most recent and relevant literature on the subject.

Neurocutaneous Disorders

Neurocutaneous Disorders
Author: Christos P. Panteliadis,Ramsis Benjamin,Christian Hagel
Publsiher: Springer Nature
Total Pages: 541
Release: 2022
ISBN: 3030878937
Category: Dermatology
Language: EN, FR, DE, ES & NL

Neurocutaneous Disorders Book Excerpt:

This book provides extensive data on the more common and many of the more rare congenital and hereditary syndromes that manifest in the nervous system and skin. Though often complex and multi-systemic, these disorders can frequently be diagnosed using a combination of simple visual inspection and sound clinical expertise. Drawing on fully referenced information from thousands of articles, the international editorial team has prepared a comprehensive overview that includes historical perspectives, clinical features, the pathogenesis, and diagnostic and therapeutic strategies. In addition, it addresses the biochemical, molecular, and genetic basis of the disorders. The book is divided into four main sections. Starting with general aspects of aetiology, diagnostics and therapy, the first part then covers the genetics, neuro-imaging, neuropathology, ocular manifestations and surgical management. The second part discusses developmental malformations, such as Sturge-Weber syndrome, Ataxia-Telangiectasia, Hypomelanosis of Ito and other rare syndromes, including haemangiomas. The focus of the third part is on tumour suppressor/DNA repair disorders, the most common of which is Neurofibromatosis 1. It also describes Neurofibromatosis 2, Schwannomatosis, Tuberous sclerosis, von Hippel-Lindau disease, Naevoid basal cell carcinoma and others. The books fourth and final section covers defects in enzymes and structural proteins, which manifest as Cerebrotendinous xanthromatosis, Ehlers-Danlos syndrome, Menkes syndrome, Refsum disease.

Glioblastoma

Glioblastoma
Author: Swapan K. Ray
Publsiher: Springer Science & Business Media
Total Pages: 431
Release: 2009-10-31
ISBN: 1441904107
Category: Medical
Language: EN, FR, DE, ES & NL

Glioblastoma Book Excerpt:

Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.

Robbins and Cotran Pathologic Basis of Disease Professional Edition E Book

Robbins and Cotran Pathologic Basis of Disease  Professional Edition E Book
Author: Vinay Kumar,Abul K. Abbas,Jon C. Aster
Publsiher: Elsevier Health Sciences
Total Pages: 1472
Release: 2014-09-05
ISBN: 0323296351
Category: Medical
Language: EN, FR, DE, ES & NL

Robbins and Cotran Pathologic Basis of Disease Professional Edition E Book Book Excerpt:

Dependable, current, and complete, Robbins and Cotran Pathologic Basis of Disease, 9th Edition is the perennially best-selling text that you’ll use long after your medical student days are behind you. A world-class author team headed by Drs. Vinay Kumar, Abul Abbas, and Jon Aster, delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content. High-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more. Rely on uniquely authoritative and readable coverage, ideal for USMLE or specialty board preparation, as well as for course work. Simplify your study with an outstanding full-color, highly user-friendly design. Stay up to date with the latest information in molecular and genetic testing and mechanisms of disease. Consult new Targeted Therapy boxes online that discuss drug therapy for specific diseases. Gain a new perspective in key areas thanks to contributions from new authors at the top of their fields. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.

Imaging of the Brain E Book

Imaging of the Brain E Book
Author: Thomas P. Naidich,Mauricio Castillo,Soonmee Cha,James G. Smirniotopoulos
Publsiher: Elsevier Health Sciences
Total Pages: 1234
Release: 2012-10-31
ISBN: 0323186475
Category: Medical
Language: EN, FR, DE, ES & NL

Imaging of the Brain E Book Book Excerpt:

Imaging of the Brain provides the advanced expertise you need to overcome the toughest diagnostic challenges in neuroradiology. Combining the rich visual guidance of an atlas with the comprehensive, in-depth coverage of a definitive reference, this significant new work in the Expert Radiology series covers every aspect of brain imaging, equipping you to make optimal use of the latest diagnostic modalities.

Tumors of the Central Nervous System Volume 5

Tumors of the Central Nervous System  Volume 5
Author: M.A. Hayat
Publsiher: Springer Science & Business Media
Total Pages: 290
Release: 2011-09-28
ISBN: 9789400720190
Category: Medical
Language: EN, FR, DE, ES & NL

Tumors of the Central Nervous System Volume 5 Book Excerpt:

The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme. The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.

Tumors of the Central Nervous System

Tumors of the Central Nervous System
Author: Lee Roy Morgan
Publsiher: BoD – Books on Demand
Total Pages: 274
Release: 2014-06-11
ISBN: 9535115766
Category: Medical
Language: EN, FR, DE, ES & NL

Tumors of the Central Nervous System Book Excerpt:

A novel concept that is reviewed and discussed in several chapters in the book alludes to the transport of drugs bound to red blood cells into the highly vascular CNS tumors - both primary and metastatic. Such a transport mechanism is unique and of significant therapeutic potential. It is hopeful that the novel information presented in this book will result in new approaches to the treatment CNS tumors.

Neuro oncology

Neuro oncology
Author: Wolfgang Grisold,Riccardo Soffietti
Publsiher: Newnes
Total Pages: 550
Release: 2012
ISBN: 0444535020
Category: Medical
Language: EN, FR, DE, ES & NL

Neuro oncology Book Excerpt:

A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. International list of contributors including the leading workers in the field. Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.